TNFRSF13C antibody (AA 1-30)

Catalog No. ABIN3029360

Product Details anti-TNFRSF13C Antibody

Target: TNFRSF13C (Tumor Necrosis Factor Receptor Superfamily, Member 13C (TNFRSF13C))

Binding Specificity: AA 1-30

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TNFRSF13C antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Purification: Antigen affinity purified

Immunogen: A portion of amino acids 1-30 from the human protein was used as the immunogen for this BAFF Receptor antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Titration of the BAFF Receptor antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the BAFF Receptor antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Target Details for TNFRSF13C

Target: TNFRSF13C (Tumor Necrosis Factor Receptor Superfamily, Member 13C (TNFRSF13C))

Alternative Name: BAFF Receptor (TNFRSF13C Products)

Synonyms: RGD1560810 antibody, TNFRSF13C antibody, BAFF-R antibody, BAFFR antibody, BROMIX antibody, CD268 antibody, CVID4 antibody, prolixin antibody, 2010006P15Rik antibody, Baffr antibody, Bcmd antibody, Bcmd-1 antibody, Bcmd1 antibody, Lvis22 antibody, TNF receptor superfamily member 13C antibody, uncharacterized LOC746611 antibody, tumor necrosis factor receptor superfamily, member 13c antibody, TNFRSF13C antibody, Tnfrsf13c antibody, LOC746611 antibody

Background: B cell-activating factor (BAFF) enhances B-cell survival in vitro and is a regulator of the peripheral B-cell population. Overexpression of Baff in mice results in mature B-cell hyperplasia and symptoms of systemic lupus erythematosus (SLE). Also, some SLE patients have increased levels of BAFF in serum. Therefore, it has been proposed that abnormally high levels of BAFF may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells. The protein encoded by this gene is a receptor for BAFF and is a type III transmembrane protein containing a single extracellular cysteine-rich domain. It is thought that this receptor is the principal receptor required for BAFF-mediated mature B-cell survival.

UniProt: Q96RJ3

Pathways: NF-kappaB Signaling