IKK alpha antibody

Catalog No. ABIN531954

Product Details anti-IKK alpha Antibody

Target: IKK alpha (CHUK) (conserved Helix-Loop-Helix Ubiquitous Kinase (CHUK))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This IKK alpha antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP)

Purpose: Mouse monoclonal antibody raised against full length recombinant CHUK.

Cross-Reactivity: Human, Monkey, Mouse

Immunogen: Recombinant His fusion protein corresponding to full length human CHUK.

Clone: 14A231

Isotype: IgG1

Application Details

Application Notes: The optimal working dilution should be determined by the end user.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In PBS (0.05 % BSA, 0.05 % sodium azide)

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.

References for anti-IKK alpha antibody (ABIN531954)

Jackson-Bernitsas, Ichikawa, Takada, Myers, Lin, Darnay, Chaturvedi, Aggarwal: "Evidence that TNF-TNFR1-TRADD-TRAF2-RIP-TAK1-IKK pathway mediates constitutive NF-kappaB activation and proliferation in human head and neck squamous cell carcinoma." in: Oncogene, Vol. 26, Issue 10, pp. 1385-97, (2007) (PubMed).

Beraza, Lüdde, Assmus, Roskams, Vander Borght, Trautwein: "Hepatocyte-specific IKK gamma/NEMO expression determines the degree of liver injury." in: Gastroenterology, Vol. 132, Issue 7, pp. 2504-17, (2007) (PubMed).

Chae, Eckmann, Miyamoto, Pothoulakis, Karin, Kagnoff: "Epithelial cell I kappa B-kinase beta has an important protective role in Clostridium difficile toxin A-induced mucosal injury." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 177, Issue 2, pp. 1214-20, (2006) (PubMed).

Richardson, Dixon, Malhotra, Hardman, Knowles, Boot-Handford, Shore, Whitmarsh, Dixon: "Irf6 is a key determinant of the keratinocyte proliferation-differentiation switch." in: Nature genetics, Vol. 38, Issue 11, pp. 1329-34, (2006) (PubMed).

Bürckstümmer, Bennett, Preradovic, Schütze, Hantschel, Superti-Furga, Bauch: "An efficient tandem affinity purification procedure for interaction proteomics in mammalian cells." in: Nature methods, Vol. 3, Issue 12, pp. 1013-9, (2006) (PubMed).

Target Details for IKK alpha

Target: IKK alpha (CHUK) (conserved Helix-Loop-Helix Ubiquitous Kinase (CHUK))

Alternative Name: IKKA (CHUK Products)

Synonyms: ikk antibody, ikk1 antibody, ikka antibody, ikkalpha antibody, CHUK antibody, IKBKA antibody, IKK-alpha antibody, IKK1 antibody, IKKA antibody, NFKBIKA antibody, TCF16 antibody, AI256658 antibody, Chuk1 antibody, Fbx24 antibody, Fbxo24 antibody, Ikka antibody, zgc:56539 antibody, conserved helix-loop-helix ubiquitous kinase S homeolog antibody, conserved helix-loop-helix ubiquitous kinase antibody, chuk.S antibody, CHUK antibody, Chuk antibody, chuk antibody

Gene ID: 1147

Pathways: PI3K-Akt Signaling, NF-kappaB Signaling, RTK Signaling, TCR Signaling, TLR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades, BCR Signaling, Ubiquitin Proteasome Pathway, S100 Proteins