PHLPP1
Reactivity: Human
WB
Host: Rabbit
Polyclonal
unconjugated
Application Notes
Western Blot (1:1000) The optimal working dilution should be determined by the end user.
Restrictions
For Research Use only
Format
Liquid
Buffer
In PBS (0.09 % sodium azide)
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
4 °C,-20 °C
Storage Comment
Store at 4°C. For long term storage store at -20°C. Aliquot to avoid repeated freezing and thawing.
Gao, Brognard, Newton: "The phosphatase PHLPP controls the cellular levels of protein kinase C." in: The Journal of biological chemistry, Vol. 283, Issue 10, pp. 6300-11, (2008) (PubMed).
Brognard, Sierecki, Gao, Newton: "PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms." in: Molecular cell, Vol. 25, Issue 6, pp. 917-31, (2007) (PubMed).
Gao, Furnari, Newton: "PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth." in: Molecular cell, Vol. 18, Issue 1, pp. 13-24, (2005) (PubMed).
Target
PHLPP1
(PH Domain and Leucine Rich Repeat Protein Phosphatase 1 (PHLPP1))