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Caspase 4 antibody (N-Term)
CASP4
Reactivity: Human
WB
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-Caspase 4 Antibody
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Target
See all Caspase 4 (CASP4) Antibodies
Caspase 4 (CASP4)
(Caspase 4, Apoptosis-Related Cysteine Peptidase (CASP4))
Binding Specificity
All epitopes for Caspase 4 antibodies
N-Term
Reactivity
All reactivities for Caspase 4 antibodies
Human
Host
All hosts for Caspase 4 antibodies
Rabbit
Clonality
All clonalities for Caspase 4 antibodies
Polyclonal
Conjugate
All conjugates for Caspase 4 antibodies
This Caspase 4 antibody is un-conjugated
Application
All applications for Caspase 4 antibodies
Western Blotting (WB)
Sequence
ADSMQEKQRM AGQMLLQTFF NIDQISPNKK AHPNMEAGPP ESGESTDALK
Characteristics
This is a rabbit polyclonal antibody against CASP4. It was validated on Western Blot.
Purification
Affinity purified
Immunogen
The immunogen is a synthetic peptide directed towards the N-terminal region of Human CASP4
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Alternatives
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Application Details
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Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Handling
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Format
Liquid
Buffer
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
-20 °C
Storage Comment
For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Target Details for Caspase 4
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Target
Caspase 4 (CASP4)
(Caspase 4, Apoptosis-Related Cysteine Peptidase (CASP4))
Alternative Name
CASP4 (CASP4 Products )
Synonyms
ICE(rel)II antibody, ICEREL-II antibody, ICH-2 antibody, Mih1/TX antibody, TX antibody, Casp11 antibody, CASP13 antibody, CASP1 antibody, CASP4 antibody, Caspl antibody, ich-3 antibody, Casp4 antibody, caspase 4 antibody, caspase 4, apoptosis-related cysteine peptidase antibody, caspase-4 antibody, CASP4 antibody, Casp4 antibody, LOC100731032 antibody
Background
This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This caspase is able to cleave and activate its own precursor protein, as well as caspase 1 precursor. When overexpressed, this gene induces cell apoptosis. Alternative splicing results in transcript variants encoding distinct isoforms. Alias Symbols: CASP4, ICH2, Protein Size: 377
Gene ID
837
UniProt
P49662
Pathways
Apoptosis , Caspase Cascade in Apoptosis , Positive Regulation of Endopeptidase Activity
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