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FAK antibody (Tyr397)
PTK2
Reactivity: Human, Mouse, Rat
WB, ELISA, IF, IHC (p)
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-FAK Antibody
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Target
See all FAK (PTK2) Antibodies
FAK (PTK2)
(PTK2 Protein tyrosine Kinase 2 (PTK2))
Binding Specificity
All epitopes for FAK antibodies
Tyr397
Reactivity
All reactivities for FAK antibodies
Human, Mouse, Rat
Host
All hosts for FAK antibodies
Rabbit
Clonality
All clonalities for FAK antibodies
Polyclonal
Conjugate
All conjugates for FAK antibodies
This FAK antibody is un-conjugated
Application
All applications for FAK antibodies
Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Specificity
FADK 1,FADK,FAK related non kinase polypeptide,FAK1,FAK1,Focal adhesion kinase 1,Focal adhesion Kinase,Focal adhesion kinase isoform FAK Del33,Focal adhesion kinase related nonkinase,FRNK,p125FAK,pp125FAK,PPP1R71,Protein phosphatase 1 regulatory subunit 71,Protein tyrosine kinase 2,Protein-tyrosine kinase 2,Ptk2,PTK2 protein tyrosine kinase 2
Purification
Affinity purification
Immunogen
Synthesized peptide derived from human FAK around the non-phosphorylation site of Tyr397.
Isotype
IgG
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Discover our top product PTK2 Primary Antibody
Alternatives
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Application Details
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Application Notes
WB 1:500-1:2000, IHC 1:100-1:300, IF 1:200-1:1000, ELISA 1:10000
Restrictions
For Research Use only
Handling
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Format
Liquid
Concentration
1 mg/mL
Buffer
PBS with 0.02 % sodium azide, 0.5 % BSA and 50 % glycerol, pH 7.4
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
-20 °C
Storage Comment
Store at -20°C. Avoid freeze / thaw cycles.
Target Details for FAK
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Target
FAK (PTK2)
(PTK2 Protein tyrosine Kinase 2 (PTK2))
Alternative Name
FAK (PTK2 Products )
Synonyms
FADK antibody, FAK antibody, FAK1 antibody, FRNK antibody, PPP1R71 antibody, p125FAK antibody, pp125FAK antibody, PTK2 antibody, Fadk antibody, mKIAA4203 antibody, fak antibody, fak1a antibody, ptk2 antibody, ptk2a antibody, wu:fa18c04 antibody, zgc:66114 antibody, CG10023 antibody, CT28129 antibody, DFAK antibody, DFak antibody, DFak56 antibody, Dfak antibody, Dfak56 antibody, DmFAK antibody, Dmel\\CG10023 antibody, Fak56 antibody, Fak56D antibody, fak56 antibody, protein tyrosine kinase 2 antibody, protein tyrosine kinase 2 L homeolog antibody, PTK2 protein tyrosine kinase 2 antibody, protein tyrosine kinase 2ab antibody, Focal adhesion kinase antibody, PTK2 antibody, ptk2.L antibody, Ptk2 antibody, ptk2ab antibody, Fak antibody
Background
Non-receptor protein-tyrosine kinase implicated in signaling pathways involved in cell motility, proliferation and apoptosis. Activated by tyrosine-phosphorylation in response to either integrin clustering induced by cell adhesion or antibody cross-linking, or via G-protein coupled receptor (GPCR) occupancy by ligands such as bombesin or lysophosphatidic acid, or via LDL receptor occupancy. Microtubule-induced dephosphorylation at Tyr-397 is crucial for the induction of focal adhesion disassembly. Plays a potential role in oncogenic transformations resulting in increased kinase activity.
Molecular Weight
119kDa
Gene ID
5747
UniProt
Q05397
Pathways
Response to Growth Hormone Stimulus , CXCR4-mediated Signaling Events , Smooth Muscle Cell Migration , Signaling of Hepatocyte Growth Factor Receptor , VEGF Signaling
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