CRTC2 antibody (C-Term)

Catalog No. ABIN615884

Product Details anti-CRTC2 Antibody

Target: CRTC2 (CREB Regulated Transcription Coactivator 2 (CRTC2))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat, Pig, Dog, Cow

Host: Goat

Clonality: Polyclonal

Conjugate: This CRTC2 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Sequence: C-DPAVEDSFRS DRLQ

Specificity: Recognizes TORC2

Cross-Reactivity (Details): Species reactivity (expected):Mouse, Rat, Dog, Pig, Cow.
Species reactivity (tested):Human.

Purification: Affinity Chromatography

Immunogen: Peptide with sequence from the C Terminus of the protein sequence according to NP_083157.1. Genename: CRTC2

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Tris saline, pH ~7.3, 0.02 % Sodium Azide, 0.5 % BSA

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for CRTC2

Target: CRTC2 (CREB Regulated Transcription Coactivator 2 (CRTC2))

Alternative Name: CRTC2 / TORC2 (CRTC2 Products)

Synonyms: CRTC2 antibody, TORC-2 antibody, TORC2 antibody, 4632407F12Rik antibody, Torc2 antibody, mTORC2 antibody, RGD1308903 antibody, CREB regulated transcription coactivator 2 antibody, CRTC2 antibody, Crtc2 antibody

Background: Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). Most abundantly expressed in the thymus. Present in both B and T lymphocytes. Highly expressed in HEK293T cells and in insulinomas. High levels also in spleen, ovary, muscle and lung, with highest levels in muscle. Lower levels found in brain, colon, heart, kidney, prostate, small intestine and stomach. Weak expression in liver and pancreas.Synonyms: CREB-regulated transcription coactivator 2, TORC-2, Transducer of CREB protein 2, Transducer of regulated cAMP response element-binding protein 2

Molecular Weight: 73.2kDa (NP_083157.1).

Gene ID: 74343

NCBI Accession: NP_083157

UniProt: Q3U182

Pathways: AMPK Signaling, Carbohydrate Homeostasis