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AIM2 antibody (Absent in Melanoma 2) Primary Antibody

AIM2 Reactivity: Human, Mouse ELISA, ICC, IF, WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6256925
$390.77
Plus shipping costs $45.00
100 μL ABIN6256925
100 μL ABIN6256925
local_shipping Shipping to: United States
Delivery in 8 to 9 Business Days
  • Target
    AIM2
    Reactivity
    • 80
    • 23
    • 18
    • 3
    • 3
    • 1
    Human, Mouse
    Host
    • 61
    • 11
    • 9
    Rabbit
    Clonality
    • 73
    • 8
    Polyclonal
    Conjugate
    • 42
    • 7
    • 6
    • 5
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This AIM2 antibody is un-conjugated
    Application
    • 64
    • 43
    • 24
    • 22
    • 20
    • 13
    • 12
    • 6
    • 5
    • 3
    • 2
    • 1
    ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF), Western Blotting (WB)
    Specificity
    AIM2 Antibody detects endogenous levels of total AIM2
    Cross-Reactivity
    Human, Mouse (Murine)
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide
    Isotype
    IgG
  • Application Notes
    WB 1:500~1:1000, IF/ICC 1:100-1:500
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20 °C.Stable for 12 months from date of receipt
    Expiry Date
    12 months
  • Target
    AIM2
    Alternative Name
    AIM2 (AIM2 Antibody Abstract)
    Synonyms
    AIM2, PYHIN4, Gm1313, Ifi210, absent in melanoma 2, AIM2, Aim2
    Background

    Description: Involved in innate immune response by recognizing cytosolic double-stranded DNA and inducing caspase-1-activating inflammasome formation in macrophages. Upon binding to DNA is thought to undergo oligomerization and to associate with PYCARD initiating the recruitment of caspase-1 precusrsor and processing of interleukin-1 beta and interleukin-18. Detects cytosolic dsDNA of viral and bacterial origin in a non-sequence-specific manner. Can also trigger PYCARD-dependent, caspase-1-independent cell death that involves caspase-8 (By similarity). Tumor suppressor which may act by repressing NF-kappa-B transcriptional activity.

    Gene: AIM2

    Molecular Weight
    39 kDa
    Gene ID
    9447
    UniProt
    O14862
    Pathways
    Activation of Innate immune Response, Positive Regulation of Endopeptidase Activity, Inflammasome
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