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DIO3 antibody

DIO3 Reactivity: Human, Rat, Mouse WB, ELISA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6261301
  • Target See all DIO3 Antibodies
    DIO3 (Deiodinase, Iodothyronine, Type III (DIO3))
    Reactivity
    Human, Rat, Mouse
    Host
    • 48
    • 1
    Rabbit
    Clonality
    • 48
    • 1
    Polyclonal
    Conjugate
    • 18
    • 7
    • 5
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This DIO3 antibody is un-conjugated
    Application
    • 39
    • 25
    • 15
    • 7
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA
    Specificity
    DIO3 Antibody detects endogenous levels of total DIO3
    Cross-Reactivity
    Human, Mouse (Murine), Rat (Rattus)
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human DIO3
    Isotype
    IgG
    Top Product
    Discover our top product DIO3 Primary Antibody
  • Application Notes
    WB 1:1000-3000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20 °C.Stable for 12 months from date of receipt
    Expiry Date
    12 months
  • Target
    DIO3 (Deiodinase, Iodothyronine, Type III (DIO3))
    Alternative Name
    DIO3 (DIO3 Products)
    Synonyms
    5DIII antibody, DIOIII antibody, txdi3 antibody, dioiii antibody, XL-15 antibody, itdi3 antibody, D3 antibody, TXDI3 antibody, iodothyronine deiodinase 3 antibody, deiodinase, iodothyronine, type 3 antibody, deiodinase, iodothyronine, type III antibody, deiodinase, iodothyronine type III antibody, deiodinase, iodothyronine, type 3 L homeolog antibody, DIO3 antibody, dio3 antibody, Dio3 antibody, dio3.L antibody
    Background

    Description: Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into RT3 (3,3',5'-triiodothyronine) and of T3 (3,5,3'-triiodothyronine) into T2 (3,3'-diiodothyronine). RT3 and T2 are inactive metabolites. May play a role in preventing premature exposure of developing fetal tissues to adult levels of thyroid hormones. Can regulate circulating fetal thyroid hormone concentrations throughout gestation. Essential role for regulation of thyroid hormone inactivation during embryological development.

    Gene: DIO3

    Molecular Weight
    31 kDa
    Gene ID
    1735
    UniProt
    P55073
    Pathways
    Hormone Activity
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