GRIK2 antibody (Internal Region)

Catalog No. ABIN6262084

Product Details anti-GRIK2 Antibody

Target: GRIK2 (Glutamate Receptor, Ionotropic, Kainate 2 (GRIK2))

Binding Specificity: Internal Region

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GRIK2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Specificity: GRIK2 Antibody detects endogenous levels of total GRIK2.

Predicted Reactivity: Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Chicken

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human GRIK2, corresponding to a region within the internal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for GRIK2

Target: GRIK2 (Glutamate Receptor, Ionotropic, Kainate 2 (GRIK2))

Alternative Name: GRIK2 (GRIK2 Products)

Synonyms: GRIK5 antibody, eaa4 antibody, glr6 antibody, gluk6 antibody, glur6 antibody, grik2 antibody, mrt6 antibody, GluR6 antibody, grik2-A antibody, EAA4 antibody, GLR6 antibody, GLUK6 antibody, GLUR6 antibody, GluK2 antibody, MRT6 antibody, AW124492 antibody, Glur-6 antibody, Glur6 antibody, Glurbeta2 antibody, GRIK2 antibody, glutamate ionotropic receptor kainate type subunit 2 antibody, glutamate receptor, ionotropic, kainate 2 L homeolog antibody, glutamate receptor, ionotropic, kainate 2 antibody, glutamate receptor, ionotropic, kainate 2 (beta 2) antibody, GRIK2 antibody, grik2.L antibody, grik2 antibody, Grik2 antibody

Background:

Description: Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist (PubMed:28180184). May be involved in the transmission of light information from the retina to the hypothalamus. Modulates cell surface expression of NETO2 (By similarity).

Gene: GRIK2

Molecular Weight: 103kDa

Gene ID: 2898

UniProt: Q13002

Pathways: Synaptic Membrane, Regulation of long-term Neuronal Synaptic Plasticity