JAK1 antibody

Catalog No. ABIN6262699

Product Details anti-JAK1 Antibody

Target: JAK1 (Janus Kinase 1 (JAK1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This JAK1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificity: JAK1 Antibody detects endogenous levels of total JAK1

Cross-Reactivity: Human, Mouse (Murine), Rat (Rattus)

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human JAK1

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000 IHC 1:50-1:200, IF/ICC 1:100-1:500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C.Stable for 12 months from date of receipt

Expiry Date: 12 months

References for anti-JAK1 antibody (ABIN6262699)

Chen, Zhou, Liu, Huang, Liu, Kang, Chen, Guo, Zhu, Sun: "Combination of gemcitabine and erlotinib inhibits recurrent pancreatic cancer growth in mice via the JAK-STAT pathway." in: Oncology reports, Vol. 39, Issue 3, pp. 1081-1089, (2018) (PubMed).

Bai, Wang, Han, Xie, Ji, Yin, Chen, Wang, Jiang, Qi, Jiang: "BCL2L10 inhibits growth and metastasis of hepatocellular carcinoma both in vitro and in vivo." in: Molecular carcinogenesis, Vol. 56, Issue 3, pp. 1137-1149, (2017) (PubMed).

Target Details for JAK1

Target: JAK1 (Janus Kinase 1 (JAK1))

Alternative Name: JAK1 (JAK1 Products)

Synonyms: JAK1A antibody, JAK1B antibody, JTK3 antibody, AA960307 antibody, C130039L05Rik antibody, wu:fb93e10 antibody, jak1 antibody, Janus kinase 1 antibody, tyrosine-protein kinase JAK1 antibody, JAK1 antibody, Jak1 antibody, jak1 antibody, LOC100286690 antibody

Background:

Description: Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway (PubMed:7615558). Kinase partner for the interleukin (IL)-2 receptor (PubMed:11909529).

Gene: JAK1

Molecular Weight: 130kDa

Gene ID: 3716

UniProt: P23458

Pathways: JAK-STAT Signaling, RTK Signaling, Interferon-gamma Pathway, Hepatitis C, Toll-Like Receptors Cascades, Unfolded Protein Response