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MICU1 antibody (AA 55-191) (Biotin)

MICU1 Reactivity: Human ELISA Host: Rabbit Polyclonal Biotin
Catalog No. ABIN7146323
  • Target See all MICU1 Antibodies
    MICU1 (Mitochondrial Calcium Uptake 1 (MICU1))
    Binding Specificity
    • 7
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 55-191
    Reactivity
    • 31
    • 9
    • 9
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 24
    • 7
    • 1
    Rabbit
    Clonality
    • 26
    • 6
    Polyclonal
    Conjugate
    • 16
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This MICU1 antibody is conjugated to Biotin
    Application
    • 22
    • 13
    • 4
    • 4
    • 2
    • 2
    • 1
    ELISA
    Cross-Reactivity
    Human
    Purification
    >95%, Protein G purified
    Immunogen
    Recombinant Human Calcium uptake protein 1, mitochondrial protein (55-191AA)
    Isotype
    IgG
    Top Product
    Discover our top product MICU1 Primary Antibody
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C,-80 °C
    Storage Comment
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target
    MICU1 (Mitochondrial Calcium Uptake 1 (MICU1))
    Alternative Name
    MICU1 (MICU1 Products)
    Synonyms
    CALC antibody, CBARA1 antibody, EFHA3 antibody, C730016L05Rik antibody, Calc antibody, Cbara1 antibody, mitochondrial calcium uptake 1 antibody, MICU1 antibody, Micu1 antibody
    Background

    Background: Key regulator of mitochondrial calcium uniporter (MCU) that senses calcium level via its EF-hand domains (PubMed:20693986, PubMed:23101630, PubMed:23747253, PubMed:24313810, PubMed:24332854, PubMed:24503055, PubMed:24560927, PubMed:26341627, PubMed:26903221, PubMed:27099988). MICU1 and MICU2 form a disulfide-linked heterodimer that stimulates and inhibits MCU activity, depending on the concentration of calcium. MICU1 acts both as an activator or inhibitor of mitochondrial calcium uptake (PubMed:26903221). Acts as a gatekeeper of MCU at low concentration of calcium, preventing channel opening (PubMed:26903221). Enhances MCU opening at high calcium concentration, allowing a rapid response of mitochondria to calcium signals generated in the cytoplasm (PubMed:24560927, PubMed:26903221). Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake (PubMed:22904319). Induces T-helper 1-mediated autoreactivity, which is accompanied by the release of IFNG (PubMed:16002733).

    Aliases: Allergen Hom s 4 antibody, ara CALC antibody, atopy related autoantigen antibody, atopy related autoantigen CALC antibody, Atopy-related autoantigen CALC antibody, CALC antibody, calcium binding atopy related autoantigen 1 antibody, Calcium uptake protein 1 antibody, calcium uptake protein 1, mitochondrial antibody, Calcium-binding atopy-related autoantigen 1 antibody, CBARA1 antibody, EFHA3 antibody, FLJ12684 antibody, MICU1 antibody, MICU1_HUMAN antibody, mitochondrial antibody, mitochondrial calcium uptake 1 antibody, MPXPS antibody

    UniProt
    Q9BPX6
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