ALK antibody

Catalog No. ABIN7339896

Product Details anti-ALK Antibody

Target: ALK (Anaplastic Lymphoma Receptor tyrosine Kinase (ALK))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ALK antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Cross-Reactivity: Human, Mouse

Purification: Antigen affinity purification

Immunogen: Synthetic peptide of Human ALK

Isotype: IgG

Application Details

Application Notes: ELISA:1:1000-1:5000, IHC:1:25-1:100,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: -20 °C, pH 7.4 PBS, 0.05 % Sodium azide, 40 % Glycerol

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for ALK

Target: ALK (Anaplastic Lymphoma Receptor tyrosine Kinase (ALK))

Alternative Name: ALK (ALK Products)

Synonyms: Tcrz antibody, CD246 antibody, NBLST3 antibody, ALK antibody, anaplastic lymphoma kinase antibody, anaplastic lymphoma receptor tyrosine kinase antibody, ALK receptor tyrosine kinase antibody, Alk antibody, ALK antibody

Background:

Background: This gene encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged, mutated, or amplified in a series of tumours including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene, which result in creation of multiple fusion genes in tumourigenesis, including ALK (chromosome 2)/EML4 (chromosome 2), ALK/RANBP2 (chromosome 2), ALK/ATIC (chromosome 2), ALK/TFG (chromosome 3), ALK/NPM1 (chromosome 5), ALK/SQSTM1 (chromosome 5), ALK/KIF5B (chromosome 10), ALK/CLTC (chromosome 17), ALK/TPM4 (chromosome 19), and ALK/MSN (chromosome X).

Aliases: Alk antibody, ALK tyrosine kinase receptor antibody, ALK/EML4 fusion gene, included antibody, ALK/NPM1 fusion gene, included antibody, ALK_HUMAN antibody, anaplastic lymphoma kinase (Ki-1) antibody, Anaplastic lymphoma kinase antibody, Anaplastic lymphoma kinase Ki1 antibody, anaplastic lymphoma receptor tyrosine kinase antibody, CD 246 antibody, CD246 antibody, CD246 antigen antibody, EC 2.7.10.1 antibody, Ki 1 antibody, Ki1 antibody, mutant anaplastic lymphoma kinase antibody, NBLST 3 antibody, NBLST3 antibody, Tcrz antibody, TFG/ALK antibody

UniProt: Q9UM73

Pathways: RTK Signaling