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TMPRSS2 antibody (Transmembrane Protease, serine 2) Primary Antibody

TMPRSS2 Reactivity: Human, Mouse, Rat IF (p), IHC (p), WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN716876
$339.90
Plus shipping costs $45.00
100 μL
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Delivery in 4 to 6 Business Days
  • Target
    TMPRSS2
    Reactivity
    Human, Mouse, Rat
    • 45
    • 24
    • 17
    • 1
    • 1
    • 1
    Host
    Rabbit
    Clonality
    Polyclonal
    Conjugate
    This TMPRSS2 antibody is un-conjugated
    • 22
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Application
    Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
    • 34
    • 16
    • 12
    • 6
    • 3
    • 3
    • 3
    • 2
    • 2
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human TMPRSS2
    Isotype
    IgG
  • Application Notes
    WB 1:100-1000
    IHC-P 1:100-500
    IF(IHC-P) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C
    Expiry Date
    12 months
  • Target
    TMPRSS2
    Alternative Name
    Prss10 (TMPRSS2 Antibody Abstract)
    Synonyms
    PP9284, PRSS10, D16Ertd61e, transmembrane protease serine 2-like, transmembrane protease, serine 2, LOC100739411, TMPRSS2, Tmprss2
    Background

    Serine protease that proteolytically cleaves and activates the viral spike glycoproteins which facilitate virus-cell membrane fusions, spike proteins are synthesized and maintained in precursor intermediate folding states and proteolysis permits the refolding and energy release required to create stable virus-cell linkages and membrane coalescence. Facilitates human SARS coronavirus (SARS-CoV) infection via two independent mechanisms, proteolytic cleavage of ACE2, which might promote viral uptake, and cleavage of coronavirus spike glycoprotein which activates the glycoprotein for cathepsin L-independent host cell entry. Proteolytically cleaves and activates the spike glycoproteins of human coronavirus 229E (HCoV-229E) and human coronavirus EMC (HCoV-EMC) and the fusion glycoproteins F0 of Sendai virus (SeV), human metapneumovirus (HMPV), human parainfluenza 1, 2, 3, 4a and 4b viruses (HPIV). Essential for spread and pathogenesis of influenza A virus (strains H1N1, H3N2 and H7N9), involved in proteolytic cleavage and activation of hemagglutinin (HA) protein which is essential for viral infectivity.

    Subcellular location: Extracellular, Secreted

    Synonyms: PP9284, PRSS10, Transmembrane protease serine 2, Serine protease 10, TMPRSS2

    Gene ID
    7113
    UniProt
    O15393
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