DIO3 antibody (AA 51-150)
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- Target See all DIO3 Antibodies
- DIO3 (Deiodinase, Iodothyronine, Type III (DIO3))
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Binding Specificity
- AA 51-150
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This DIO3 antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Cross-Reactivity
- Human
- Predicted Reactivity
- Mouse,Rat,Dog,Cow,Sheep,Pig
- Purification
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human Dio3
- Isotype
- IgG
- Top Product
- Discover our top product DIO3 Primary Antibody
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- Application Notes
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WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
- Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Storage
- 4 °C,-20 °C
- Storage Comment
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- Expiry Date
- 12 months
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- Target
- DIO3 (Deiodinase, Iodothyronine, Type III (DIO3))
- Alternative Name
- Dio3 (DIO3 Products)
- Synonyms
- 5DIII antibody, DIOIII antibody, txdi3 antibody, dioiii antibody, XL-15 antibody, itdi3 antibody, D3 antibody, TXDI3 antibody, iodothyronine deiodinase 3 antibody, deiodinase, iodothyronine, type 3 antibody, deiodinase, iodothyronine, type III antibody, deiodinase, iodothyronine type III antibody, deiodinase, iodothyronine, type 3 L homeolog antibody, DIO3 antibody, dio3 antibody, Dio3 antibody, dio3.L antibody
- Background
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Synonyms: Type 3 DI, D3, 5DIII, Deiodinase iodothyronine type 3, Deiodinase iodothyronine type III, Dio 3, DIOIII, MGC124117, MGC124118, TXDI3, Type III 5' deiodinase, Type III iodothyronine deiodinase, IOD3_HUMAN.
Background: Dio3 belongs to the iodothyronine deiodinase family. It has an essential role for regulation of thyroid hormone inactivation during embryological development in that it catalyzes the inactivation of thyroid hormone by inner ring deiodination of the prohormone thyroxine (T4) and the bioactive hormone 3,3',5-triiodothyronine (T3) to inactive metabolites, 3,3',5'-triiodothyronine (RT3) and 3,3'-diiodothyronine (T2), respectively. Dio3 may play a role in preventing premature exposure of developing fetal tissues to adult levels of thyroid hormones and has been linked to the development of consumptive hypothyroidism in both infants and adults.
- Gene ID
- 1735
- Pathways
- Hormone Activity
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