EIF2AK2 antibody

Catalog No. ABIN966853

Product Details anti-EIF2AK2 Antibody

Target: EIF2AK2 (Eukaryotic Translation Initiation Factor 2-alpha Kinase 2 (EIF2AK2))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EIF2AK2 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Specificity: PKR (Ab-446) antibody detects endogenous levels of total PKR protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: The antiserum was produced against synthesized non-phosphopeptide derived from human PKR around the phosphorylation site of threonine 446 (K-R-TP-R-S).

Application Details

Application Notes: WB: 1:500~1:1000
IHC: 1:50~1:100.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 100ug/100ul.

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

References for anti-EIF2AK2 antibody (ABIN966853)

Guerra, López-Fernández, García, Zaballos, Esteban et al.: "Human gene profiling in response to the active protein kinase, interferon-induced serine/threonine protein kinase (PKR), in infected cells. Involvement of the transcription factor ATF-3 IN ..." in: The Journal of biological chemistry, Vol. 281, Issue 27, pp. 18734-45, (2006) (PubMed).

Ryman, Meier, Nangle, Ragsdale, Korneeva, Rhoads, MacDonald, Klimstra: "Sindbis virus translation is inhibited by a PKR/RNase L-independent effector induced by alpha/beta interferon priming of dendritic cells." in: Journal of virology, Vol. 79, Issue 3, pp. 1487-99, (2005) (PubMed).

Pataer, Vorburger, Barber, Chada, Mhashilkar, Zou-Yang, Stewart, Balachandran, Roth, Hunt, Swisher: "Adenoviral transfer of the melanoma differentiation-associated gene 7 (mda7) induces apoptosis of lung cancer cells via up-regulation of the double-stranded RNA-dependent protein kinase (PKR)." in: Cancer research, Vol. 62, Issue 8, pp. 2239-43, (2002) (PubMed).

Target Details for EIF2AK2

Target: EIF2AK2 (Eukaryotic Translation Initiation Factor 2-alpha Kinase 2 (EIF2AK2))

Alternative Name: PKR (EIF2AK2 Products)

Synonyms: PKR antibody, pkr antibody, EIF2AK2 antibody, DKFZp469K1934 antibody, EIF2AK1 antibody, PRKR antibody, 2310047A08Rik antibody, 4732414G15Rik antibody, AI467567 antibody, AI747578 antibody, Pkr antibody, Prkr antibody, Tik antibody, eukaryotic translation initiation factor 2 alpha kinase 2 antibody, eukaryotic translation initiation factor 2-alpha kinase 2 antibody, EIF2AK2 antibody, eif2ak2 antibody, Eif2ak2 antibody

Pathways: DNA Damage Repair, ER-Nucleus Signaling, Hepatitis C