AKT antibody (V-Akt Murine Thymoma Viral Oncogene Homolog 1)

Details for Product anti-AKT1 Antibody No. ABIN968951, Supplier: Log in to see
Antigen
  • AKT
  • CWS6
  • PKB
  • PKB-ALPHA
  • PRKBA
  • RAC
  • RAC-ALPHA
  • Akt
  • Rac
  • PKB/Akt
  • PKBalpha
  • AKT/PKB
  • AKT1
  • Akt/PKB
  • Akt1
  • CG4006
  • D-Akt
  • DAKT1
  • DAKT1/PKB
  • DAkt
  • DAkt1
  • DPKB
  • DRAC-PK
  • DRAC-PK66
  • DRAC-PK85
  • Dakt
  • Dakt1
  • Dmel\\CG4006
  • Dpkb
  • PKB/AKT
  • PKB/dAKT
  • RacPK
  • akt
  • akt1
  • dAKT
  • dAKT/dPKB
  • dAKT1
  • dAkt
  • dAkt/PKB
  • dAkt1
  • dPKB
  • dakt
  • dakt1
  • l(3)04226
  • l(3)89Bq
  • p-Akt
  • pAkt
  • ACT-5
  • akt-1
  • pkb
  • v-akt
  • v-akt1
  • xAct
  • ATAKT1
  • F18A8.2
  • F18A8_2
  • K+ transporter 1
  • POTASSIUM TRANSPORTER
  • AKT serine/threonine kinase 1
  • thymoma viral proto-oncogene 1
  • CG4006 gene product from transcript CG4006-RE
  • actin beta
  • v-akt murine thymoma viral oncogene homolog 1 S homeolog
  • v-akt murine thymoma viral oncogene homolog 1
  • K+ transporter 1
  • Serine/threonine-protein kinase akt-1
  • AKT1
  • Akt1
  • ACTB
  • akt1.S
  • akt1
  • KT1
  • akt-1
Alternatives
anti-Human AKT antibody for Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections)
Reactivity
Human, Mouse (Murine), Monkey
1305
745
603
68
55
54
52
44
31
29
6
6
6
5
4
3
3
3
3
1
1
1
1
Host
Mouse
1032
356
11
4
2
2
Clonality (Clone)
Monoclonal ()
Conjugate
This AKT antibody is un-conjugated
55
43
39
39
31
26
12
12
7
7
7
5
5
5
5
5
5
4
4
4
4
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
Application
ELISA, Western Blotting (WB)
1209
621
601
283
205
195
134
110
61
38
32
26
12
11
10
4
4
3
3
2
2
1
1
1
1
1
1
1
Options
Supplier
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Supplier Product No.
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Immunogen Purified recombinant fragment of human AKT1 expressed in E. Coli.
Clone 3A3
Isotype IgG1
Purification Ascites
Plasmids, Primers & others Plasmids, Primers & others AKT products on genomics-online (e.g. as negative or positive controls)
Antigen
Alternative Name AKT1 (AKT1 Antibody Abstract)
Background The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Multiple alternatively spliced transcript variants have been found for this gene.
Molecular Weight 56 kDa
Gene ID 207
HGNC 207
Pathways PI3K-Akt Signaling, RTK Signaling, TCR Signaling, AMPK Signaling, Interferon-gamma Pathway, TLR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Response to Water Deprivation, Regulation of Actin Filament Polymerization, Carbohydrate Homeostasis, Glycosaminoglycan Metabolic Process, Cellular Glucan Metabolic Process, Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Regulation of Cell Size, Skeletal Muscle Fiber Development, Regulation of Carbohydrate Metabolic Process, Hepatitis C, Protein targeting to Nucleus, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, Negative Regulation of intrinsic apoptotic Signaling, Thromboxane A2 Receptor Signaling, Signaling of Hepatocyte Growth Factor Receptor, Positive Regulation of fat Cell Differentiation, VEGFR1 Specific Signals, VEGF Signaling
Application Notes ELISA: 1:10000, WB: 1:500 - 1:2000
Restrictions For Research Use only
Format Liquid
Buffer Ascitic fluid containing 0.03 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C,-20 °C
Storage Comment 4°C, -20°C for long term storage
Supplier Images
Western Blotting (WB) image for anti-V-Akt Murine Thymoma Viral Oncogene Homolog 1 (AKT1) antibody (ABIN968951) Figure 1: Western blot analysis using AKT1 mouse mAb against NIH/3T3 (1), Hela (2) ,C...
Product cited in: Zhao, Chen, Cai, Yang, Sui, Fu: "Angiotensin II/angiotensin II type I receptor (AT1R) signaling promotes MCF-7 breast cancer cells survival via PI3-kinase/Akt pathway." in: Journal of cellular physiology, Vol. 225, Issue 1, pp. 168-73, 2010 (PubMed).

Background publications DSouza-Schorey, Boshans, McDonough, Stahl, Van Aelst: "A role for POR1, a Rac1-interacting protein, in ARF6-mediated cytoskeletal rearrangements." in: The EMBO journal, Vol. 16, Issue 17, pp. 5445-54, 1997 (PubMed).

Datta, Franke, Chan, Makris, Yang, Kaplan, Morrison, Golemis, Tsichlis: "AH/PH domain-mediated interaction between Akt molecules and its potential role in Akt regulation." in: Molecular and cellular biology, Vol. 15, Issue 4, pp. 2304-10, 1995 (PubMed).

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