anti-Rat (Rattus) LAT2 antibody for Western Blotting

Recommended LAT2 Antibody (supplied by: Log in to see )

Antigen
Linker For Activation of T Cells Family, Member 2 (LAT2) Antibodies
  • LAB
  • NTAL
  • WBSCR15
  • WBSCR5
  • WSCR5
  • LAT2
  • MGC139435
  • Ntal
  • Wbscr5
  • AW125574
  • Wbscr15
  • linker for activation of T-cells family member 2
  • linker for activation of T cells family, member 2
  • LAT2
  • Lat2
Epitope
AA 30-203
16
15
11
11
11
10
8
8
6
5
5
5
4
2
2
2
2
2
2
2
1
1
1
1
1
Reactivity
Mouse (Murine), Rat (Rattus)
118
35
23
3
3
3
1
1
1
1
1
Host
Rabbit
94
36
14
1
Clonality
Polyclonal
Conjugate
This LAT2 antibody is un-conjugated
8
6
6
3
3
3
1
1
1
1
1
1
Application
Immunocytochemistry (ICC), Western Blotting (WB)
134
43
32
29
21
16
11
6
5
3
3
2
1
1
Options
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Available images

Catalog No. ABIN125755
$ 428.84
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
13.301073 ABIN6388317 ELISA WB Rabbit IgG AA 80-160 Log in to see Polyclonal 0
13.301073 ABIN6390516 ELISA WB Rabbit IgG Log in to see Polyclonal 0
10.843919 ABIN1859617 ICC IHC WB Rabbit IgG AA 32-192 Log in to see Polyclonal 0
10.843919 ABIN2937602 IF/ICC IHC IP WB Rabbit AA 32-192 Log in to see Polyclonal 0
7 ABIN238345 IF WB Rabbit AA 30-203 Log in to see Polyclonal 5
4.8439183 ABIN2789575 WB Rabbit C-Term Log in to see Polyclonal 0
4.8439183 ABIN2706464 WB Rabbit Center Log in to see Polyclonal 0
4.8439183 ABIN223503 WB Rabbit IgG Log in to see Polyclonal 0
4.8439183 ABIN6271722 ELISA WB Rabbit IgG pTyr136 Log in to see Polyclonal 0
4.8439183 ABIN5870423 WB Rabbit pTyr136 Log in to see Polyclonal 0
4.8439183 ABIN2971175 WB Rabbit Center Log in to see Polyclonal 0
4.8439183 ABIN549394 WB Rabbit Log in to see Polyclonal 0
4 ABIN961896 WB Rabbit Log in to see Polyclonal 0
1 ABIN207126 ICC WB Rabbit AA 30-203 Log in to see Polyclonal 0
1 ABIN2612375 WB Rabbit IgG AA 32-192 Log in to see Polyclonal 0
1 ABIN2624776 WB Biotin Rabbit IgG AA 32-192 Log in to see Polyclonal 0
1 ABIN2624778 WB FITC Rabbit IgG AA 32-192 Log in to see Polyclonal 0
1 ABIN2742550 ICC WB Rabbit AA 30-203 Log in to see Polyclonal 0
1 ABIN2297670 WB Rabbit IgG Log in to see Polyclonal 0
1 ABIN2301412 IC IHC ELISA WB Rabbit IgG AA 32-192 Log in to see Polyclonal 0

General

Antigen Linker For Activation of T Cells Family, Member 2 (LAT2) Antibodies
Epitope AA 30-203
(16), (15), (11), (11), (11), (10), (8), (8), (6), (5), (5), (5), (4), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1)
Reactivity Mouse (Murine), Rat (Rattus)
(118), (35), (23), (3), (3), (3), (1), (1), (1), (1), (1)
Host Rabbit
(94), (36), (14), (1)
Clonality
Polyclonal
Conjugate This LAT2 antibody is un-conjugated
(8), (6), (6), (3), (3), (3), (1), (1), (1), (1), (1), (1)
Application Immunocytochemistry (ICC), Western Blotting (WB)
(134), (43), (32), (29), (21), (16), (11), (6), (5), (3), (3), (2), (1), (1)
Pubmed 5 references available
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Product Details anti-LAT2 Antibody

Target Details LAT2 Application Details Handling References for anti-LAT2 antibody (ABIN125755) Images
Specificity The polyclonal antibody reacts with Non-T cell Activation Linker (NTAL), also known as LAB (linker of activated B cells), a 25 kDa transmembrane adaptor protein present in membrane microdomains (rafts) of B cells, NK cells and myeloid cells.
No Cross-Reactivity Human
Cross-Reactivity (Details) Mouse, Rat, Other species Not tested
Purification Purified from rabbit serum by affinity chromatography
Purity > 95 % (by SDS-PAGE)
Immunogen Recombinant mouse NTAL (aa 30-203).
Plasmids, Primers & others

Target Details LAT2

Product Details anti-LAT2 Antibody Application Details Handling References for anti-LAT2 antibody (ABIN125755) Images back to top
Antigen
Alternative Name NTAL / LAB (LAT2 Antibody Abstract)
Background NTAL (Non-T cell activation linker), also known as LAB (Linker for activation of B cells), is a 30 kDa double-palmitoylated transmembrane adaptor protein expressed by B cells, NK cells, mast cells and macrophages. It is a negative regulator of early stages of BCR-dependent B cell signaling and serves as a negative regulator also in mast cells. However, in mast cells, NTAL also contributes to some activation processes, partially overlapping with LAT function.
Pathways Fc-epsilon Receptor Signaling Pathway

Application Details

Product Details anti-LAT2 Antibody Target Details LAT2 Handling References for anti-LAT2 antibody (ABIN125755) Images back to top
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only

Handling

Product Details anti-LAT2 Antibody Target Details LAT2 Application Details References for anti-LAT2 antibody (ABIN125755) Images back to top
Concentration 1 mg/mL
Buffer Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Do not freeze.
Storage 4 °C
Storage Comment Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on vial label.

References for anti-LAT2 antibody (ABIN125755)

Product Details anti-LAT2 Antibody Target Details LAT2 Application Details Handling Images back to top
Background publications

Yamasaki, Ishikawa, Sakuma, Kanagawa, Cheng, Malissen, Saito: "LAT and NTAL mediate immunoglobulin E-induced sustained extracellular signal-regulated kinase activation critical for mast cell survival." in: Molecular and cellular biology, Vol. 27, Issue 12, pp. 4406-15, 2007

Horejsí, Zhang, Schraven: "Transmembrane adaptor proteins: organizers of immunoreceptor signalling." in: Nature reviews. Immunology, Vol. 4, Issue 8, pp. 603-16, 2004

Product cited in:

Lebduska, Korb, T?mová, Heneberg, Dráber: "Topography of signaling molecules as detected by electron microscopy on plasma membrane sheets isolated from non-adherent mast cells." in: Journal of immunological methods, Vol. 328, Issue 1-2, pp. 139-51, 2007

Heneberg, Lebduska, Dráberová, Korb, Dráber: "Topography of plasma membrane microdomains and its consequences for mast cell signaling." in: European journal of immunology, Vol. 36, Issue 10, pp. 2795-806, 2006

Volná, Lebduska, Dráberová, Símová, Heneberg, Boubelík, Bugajev, Malissen, Wilson, Horejsí, Malissen, Dráber: "Negative regulation of mast cell signaling and function by the adaptor LAB/NTAL." in: The Journal of experimental medicine, Vol. 200, Issue 8, pp. 1001-13, 2004

Images

Product Details anti-LAT2 Antibody Target Details LAT2 Application Details Handling References for anti-LAT2 antibody (ABIN125755) back to top
Supplier Images
Immunocytochemistry (ICC) image for anti-Linker For Activation of T Cells Family, Member 2 (LAT2) (AA 30-203) antibody (ABIN125755) Distribution of LAT and NTAL in separate clusters on mast cell plasma membrane sheets...
Immunocytochemistry (ICC) image for anti-Linker For Activation of T Cells Family, Member 2 (LAT2) (AA 30-203) antibody (ABIN125755) Distribution of LAT and NTAL in separate clusters on mast cell plasma membrane sheets...