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Minichromosome Maintenance Deficient 4 Products

(Minichromosome Maintenance Deficient 4 (MCM4))

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The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 6 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of this protein by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the MCM complex. This gene is mapped to a region on the chromosome 8 head-to-head next to the PRKDC/DNA-PK, a DNA-activated protein kinase involved in the repair of DNA double-strand breaks. Alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008].

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Featured Minichromosome Maintenance Deficient 4 Categories

Minichromosome Maintenance Deficient 4 Antibodies

High quality antibodies with extensive validation data.

Minichromosome Maintenance Deficient 4 ELISA Kits

Reliable ELISA kits for a wide range of species.

Minichromosome Maintenance Deficient 4 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended Minichromosome Maintenance Deficient 4 Antibodies

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Reactivity
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Reactivity Human
Application WB, IF, IP
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Cat. No. ABIN950014
Quantity 100 μL
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Reactivity Human
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Cat. No. ABIN517777
Quantity 50 μg
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Reactivity Human
Application WB, IHC, ELISA, IF
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Cat. No. ABIN7150334
Quantity 100 μg
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Recommended Minichromosome Maintenance Deficient 4 ELISA Kits

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Reactivity
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Reactivity Human, Mouse
Analytical Method Qualitative Cell ELISA
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Cat. No. ABIN1380406
Quantity 2 x 96 tests
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Recommended Minichromosome Maintenance Deficient 4 Proteins

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Source Wheat germ
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Cat. No. ABIN1310553
Quantity 10 μg
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Cat. No. ABIN1310555
Quantity 10 μg
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Source HEK-293 Cells
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Cat. No. ABIN2725632
Quantity 20 μg
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Latest Publications for our Minichromosome Maintenance Deficient 4 products

Flach, Bakker, Mohrin, Conroy, Pietras, Reynaud, Alvarez, Diolaiti, Ugarte, Forsberg, Le Beau, Stohr, Méndez, Morrison, Passegué: "Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells." in: Nature, Vol. 512, Issue 7513, pp. 198-202, (2014) (PubMed).

Song, Lafont, Chen, Wu, Shirahige, Rankin: "Cohesin acetylation promotes sister chromatid cohesion only in association with the replication machinery." in: The Journal of biological chemistry, Vol. 287, Issue 41, pp. 34325-36, (2012) (PubMed).

Henderson, Hall, Prpic, Hessling, Parker, Sampson, Simkins, Brough, Dixon, Lenz, Knapp, Murphy, Taylor, Fischer, Malinowski: "The selection and characterization of antibodies to minichromosome maintenance proteins that highlight cervical dysplasia." in: Journal of immunological methods, Vol. 370, Issue 1-2, pp. 1-13, (2011) (PubMed).

Orr, Gaymes, Ladon, Chronis, Czepulkowski, Wang, Mufti, Marcotte, Thomas: "Reducing MCM levels in human primary T cells during the G(0)-->G(1) transition causes genomic instability during the first cell cycle." in: Oncogene, Vol. 29, Issue 26, pp. 3803-14, (2010) (PubMed).

Tsuruga, Yabuta, Hashizume, Ikeda, Endo, Nojima: "Expression, nuclear localization and interactions of human MCM/P1 proteins." in: Biochemical and biophysical research communications, Vol. 236, Issue 1, pp. 118-25, (1997) (PubMed).

Musahl, Schulte, Burkhart, Knippers: "A human homologue of the yeast replication protein Cdc21. Interactions with other Mcm proteins." in: European journal of biochemistry / FEBS, Vol. 230, Issue 3, pp. 1096-101, (1995) (PubMed).

Hu, Burkhart, Schulte, Musahl, Knippers: "The P1 family: a new class of nuclear mammalian proteins related to the yeast Mcm replication proteins." in: Nucleic acids research, Vol. 21, Issue 23, pp. 5289-93, (1994) (PubMed).

Coxon, Maundrell, Kearsey: "Fission yeast cdc21+ belongs to a family of proteins involved in an early step of chromosome replication." in: Nucleic acids research, Vol. 20, Issue 21, pp. 5571-7, (1993) (PubMed).

Koonin: "A common set of conserved motifs in a vast variety of putative nucleic acid-dependent ATPases including MCM proteins involved in the initiation of eukaryotic DNA replication." in: Nucleic acids research, Vol. 21, Issue 11, pp. 2541-7, (1993) (PubMed).

Synonyms and alternative names related to Minichromosome Maintenance Deficient 4

minichromosome maintenance complex component 4 L homeolog (mcm4.L), minichromosome maintenance complex component 4 S homeolog (mcm4.S), minichromosome maintenance complex component 4 (MCM4), minichromosome maintenance complex component 4 (mcm4), minichromosome maintenance complex component 4 (Mcm4), 19G, AI325074, AU045576, cb1025, cdc21, CDC21, Cdc21, CDC54, fc12c09, fj85g09, hCdc21, hm:zeh1616, mcdc21, Mcmd4, mKIAA4003, NKCD, NKGCD, P1-CDC21, wu:fc12c09, wu:fj85g09, zeh1616

Protein level used designations for Minichromosome Maintenance Deficient 4

  • DNA replication licensing factor mcm4-B
  • xMCM4-B
  • P1-CDC21-B
  • CDC21 homolog-B
  • minichromosome maintenance protein 4-B
  • CDC21 homolog-A
  • DNA replication licensing factor mcm4-A
  • P1-CDC21-A
  • minichromosome maintenance deficient 4
  • minichromosome maintenance protein 4-A
  • p98
  • xMCM4-A
  • CDC21 homolog
  • DNA replication licensing factor MCM4
  • homolog of S. pombe cell devision cycle 21
  • MCM4 minichromosome maintenance deficient 4
  • DNA replication licensing factor mcm4
  • minichromosome maintenance protein 4
  • P1-CDC21
  • mini chromosome maintenance deficient 4 homolog
  • minichromosome maintenance deficient 4 homolog
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