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|Epitope||Middle Region Alternatives|
|Reactivity||Human, Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This Manic Fringe antibody is un-conjugated Alternatives|
Western Blotting (WB)
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Product Details anti-Manic Fringe AntibodyTarget Details Manic Fringe Application Details Handling Images
|Specificity||MFNG antibody was raised against the middle region of MFNG|
|Immunogen||MFNG antibody was raised using the middle region of MFNG corresponding to a region with amino acids MAPWASGSRFMDTSALIRLPDDCTMGYIIECKLGGRLQPSPLFHSHLETL|
Target Details Manic FringeProduct Details anti-Manic Fringe Antibody Application Details Handling Images back to top
|Alternative Name||MFNG (MFNG Antibody Abstract)|
|Background||MFNG is one of the evolutionarily conserved secreted proteins that act in the Notch receptor pathway to demarcate boundaries during embryonic development. This gene is a member of the fringe gene family which also includes Radical and Lunatic fringe. They all encode evolutionarily conserved secreted proteins that act in the Notch receptor pathway to demarcate boundaries during embryonic development. While their genomic structure is distinct from other glycosyltransferases, fringe proteins have a fucose-specific beta1,3 N-acetylglucosaminyltransferase activity that leads to elongation of O-linked fucose residues on Notch, which alters Notch signaling.|
|Molecular Weight||36 kDa (MW of target protein)|
Application DetailsProduct Details anti-Manic Fringe Antibody Target Details Manic Fringe Handling Images back to top
WB: 0.25 µg/mL
Optimal conditions should be determined by the investigator.
MFNG Blocking Peptide, catalog no. 33R-5720, is also available for use as a blocking control in assays to test for specificity of this MFNG antibody
|Restrictions||For Research Use only|
HandlingProduct Details anti-Manic Fringe Antibody Target Details Manic Fringe Application Details Images back to top
|Reconstitution||Lyophilized powder. Add distilled water for a 1 mg/mL concentration of MFNG antibody in PBS|
Avoid repeated freeze/thaw cycles.
Dilute only prior to immediate use.
|Storage Comment||Store at 2-8 °C for short periods. For longer periods of storage, store at -20 °C.|
ImagesProduct Details anti-Manic Fringe Antibody Target Details Manic Fringe Application Details Handling back to top