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Human Polyclonal MEFV Primary Antibody for WB - ABIN1881537
Cosan, Ustek, Oku, Duymaz-Tozkir, Cakiris, Abaci, Ocal, Aral, Gül: Association of familial Mediterranean fever-related MEFV variations with ankylosing spondylitis. in Arthritis and rheumatism 2010
Show all 4 Pubmed References
Human Polyclonal MEFV Primary Antibody for IP, WB - ABIN1169260
Papin, Cuenin, Agostini, Martinon, Werner, Beer, Grütter, Grütter, Tschopp: The SPRY domain of Pyrin, mutated in familial Mediterranean fever patients, interacts with inflammasome components and inhibits proIL-1beta processing. in Cell death and differentiation 2007
Human Polyclonal MEFV Primary Antibody for ELISA, WB - ABIN561791
Taskiran, Cetinkaya, Balci-Peynircioglu, Akkaya, Yilmaz: The effect of colchicine on pyrin and pyrin interacting proteins. in Journal of cellular biochemistry 2012
Human Polyclonal MEFV Primary Antibody for ELISA, WB - ABIN269824
Rabinovich, Livneh, Langevitz, Brezniak, Shinar, Pras, Shinar: Severe disease in patients with rheumatoid arthritis carrying a mutation in the Mediterranean fever gene. in Annals of the rheumatic diseases 2005
A novel single base mutation in the coding region of the MEFV gene, named K447M (p.Lys447Met, c.1340 A>T) heterozygote resulting in mutated Pyrin/Marenostrin protein was detected.
Propose that a variant allele of the MEFV gene may be responsible for the severity of gout.
Carrying the pro-inflammatory M694V mutation in MEFV can be a potential cause of early coronary heart disease.
Carriage of mutations in the MEFV gene is not associated with development of Postpericardiotomy Syndrome; however, it may affect Postpericardiotomy Syndrome severity.
One third of our childhood MS patients had a heterozygous mutation in the TNFRSF1A (show TNFRSF1A Antibodies) and/or MEFV gene. This proportion by far exceeds the number of mutations expected and was higher than in adult MS patients, suggesting that these mutations might contribute to the pathogenesis of childhood MS.
The frequency of MEFV gene mutation was detected at a high rate of 35.9% in patients with biopsy-proven primary glomerulonephritis
Sequencing analysis found exon 2 mutations of the MEFV gene (c.329T>C [L110P], and c.442G>C [E148Q]). INTERVENTION: Her arthritis was well-controlled with colchicine treatment, but fever, and rashes were not. OUTCOMES: She eventually received tocilizumab, in addition to colchicine, and her symptoms completely disappeared. LESSONS: MEFV mutations may exist in AOSD patients, and treatment with colchicine might
Pyrin inflammasome activation persisted upon microtubule disassembly in PBMCs of FMF patients but not in cells of patients afflicted with other autoinflammatory diseases.
A novel missense MEFV variant R204H was identified in Iranian familial Mediterranean fever patients. M694V is the most common MEFV mutation in Iran.
This article summarizes the broad spectrum of clinical presentations associated with MEFV mutations and analyzes the effect of the gene dose on the phenotypical expression. Furthermore, the impact of the molecular genetic analysis on the diagnostics of a patient and on the individualized management of the disease is discussed.
Pyrin (MEFV) is required for inflammasome activation and IL18 (show IL18 Antibodies) maturation, which promote intestinal barrier integrity and prevent colon inflammation and tumorigenesis.
Mechanistically, Yersinia pseudotuberculosis YopM recruits and activates the mouse host kinases PRK1 (show PKN1 Antibodies) and PRK2 (show PKN2 Antibodies) to negatively regulate pyrin by phosphorylation.
These results are consistent with a model in which pyrin acts to limit the release of IL-1beta (show IL1B Antibodies) generated by activation and assembly of inflammasomes in response to subclinical immune challenges.
pyrin has a critical role in the innate immune response, possibly by acting on ASC (show STS Antibodies), a known caspase-1 (show CASP1 Antibodies) activator
This gene encodes a protein, also known as pyrin or marenostrin, that is an important modulator of innate immunity. Mutations in this gene are associated with Mediterranean fever, a hereditary periodic fever syndrome.
Mediterranean fever protein
, Mediterranean fever
, familial mediterranean fever