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eIF4EBP1 Protein (AA 2-118) (His tag)

EIF4EBP1 Origin: Human Host: Escherichia coli (E. coli) Recombinant > 95 % as determined by reducing SDS-PAGE.
Catalog No. ABIN1095951
  • Target See all eIF4EBP1 (EIF4EBP1) Proteins
    eIF4EBP1 (EIF4EBP1) (Eukaryotic Translation Initiation Factor 4E Binding Protein 1 (EIF4EBP1))
    Protein Type
    Recombinant
    Protein Characteristics
    AA 2-118
    Origin
    • 7
    • 2
    • 2
    • 1
    Human
    Source
    • 9
    • 1
    • 1
    • 1
    Escherichia coli (E. coli)
    Purification tag / Conjugate
    This eIF4EBP1 protein is labelled with His tag.
    Purpose
    Recombinant Human EIF4E-Binding Protein 1/EIF4EBP1 (N-6His)
    Sequence
    MGSSHHHHHH SSGLVPRGSH MSGGSSCSQT PSRAIPATRR VVLGDGVQLP PGDYSTTPGG TLFSTTPGGT RIIYDRKFLM ECRNSPVTKT PPRDLPTIPG VTSPSSDEPP MEASQSHLRN SPEDKRAGGE ESQFEMDI
    Characteristics
    Recombinant Human Eukaryotic Translation Initiation Factor 4E-Binding Protein 1/4EBP1 is produced by our E. coli expression system. The target protein is expressed with sequence (Ser2-Ile118) of Human 4EBP1.
    Purity
    > 95 % as determined by reducing SDS-PAGE.
    Sterility
    0.2 μm filtered
    Endotoxin Level
    Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test
    Top Product
    Discover our top product EIF4EBP1 Protein
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    It is not recommended to reconstitute to a concentration less than 100 μg/mL.
    Dissolve the lyophilized protein in ddH2O.
    Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
    Buffer
    Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.4.
    Handling Advice
    Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
    Storage
    4 °C/-20 °C/-80 °C
    Storage Comment
    Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
    Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
    Aliquots of reconstituted samples are stable at < -20°C for 3 months.
    Expiry Date
    3 months
  • Target
    eIF4EBP1 (EIF4EBP1) (Eukaryotic Translation Initiation Factor 4E Binding Protein 1 (EIF4EBP1))
    Alternative Name
    4ebp1 (EIF4EBP1 Products)
    Synonyms
    4E-BP1 Protein, 4EBP1 Protein, BP-1 Protein, PHAS-I Protein, 4e-bp1 Protein, AA959816 Protein, 153432_at Protein, 43-BP Protein, 4E-BP Protein, 4EBP Protein, 4e-bp Protein, 4eBP Protein, 4ebp Protein, BcDNA.HL08053 Protein, BcDNA:HL08053 Protein, CG8846 Protein, CT8705 Protein, Dm 4E-BP Protein, Dmel\\CG8846 Protein, Phas1 Protein, Thor/EIF4EBP Protein, anon-WO0172774.158 Protein, d4E-BP Protein, d4E-BP1 Protein, d4EBP Protein, d4e-bp Protein, d4eBP Protein, dthor Protein, eIF4E-BP Protein, l(2)06270 Protein, l(2)k07736 Protein, l(2)k13517 Protein, pp20 Protein, thor Protein, EIF4EBP1 Protein, fc04h09 Protein, wu:fc04h09 Protein, zgc:64137 Protein, eukaryotic translation initiation factor 4E binding protein 1 Protein, CG8846 gene product from transcript CG8846-RA Protein, EIF4EBP1 Protein, Eif4ebp1 Protein, Thor Protein, eif4ebp1 Protein
    Background
    Eukaryotic Translation Initiation Factor 4E-Binding Protein 1 (4EBP1) is a number of the eIF4E-binding protein family. 4EBP1 regulates eIF4E activity by preventing its assembly into the eIF4F complex. 4EBP1 mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways. Non-phosphorylated 4EBP1 competes with EIF4G1/EIF4G3 to interact with EIF4E. 4EBP1 is phosphorylated in response to various signals including insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation. 4EBP1 has a role in progression of breast neoplasms through cell signaling.
    Alternative Names: Eukaryotic Translation Initiation Factor 4E-Binding Protein 1, 4E-BP1, eIF4E-Binding Protein 1, Phosphorylated Heat- and Acid-Stable Protein Regulated by Insulin 1, PHAS-I, EIF4EBP1
    Molecular Weight
    14.74 kDa
    UniProt
    Q13541
    Pathways
    MAPK Signaling, PI3K-Akt Signaling, RTK Signaling, AMPK Signaling, Regulation of Cell Size, BCR Signaling
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