Thymic Stromal Lymphopoietin Protein (TSLP) (AA 29-159) (His tag)
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- Target See all Thymic Stromal Lymphopoietin (TSLP) Proteins
- Thymic Stromal Lymphopoietin (TSLP)
- Protein Type
- Recombinant
- Protein Characteristics
- AA 29-159
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This Thymic Stromal Lymphopoietin protein is labelled with His tag.
- Application
- SDS-PAGE (SDS)
- Sequence
- MGSSHHHHHH SSGLVPRGSH MGSYDFTNCD FEKIKAAYLS TISKDLITYM SGTKSTEFNN TVSCSNRPHC LTEIQSLTFN PTAGCASLAK EMFAMKTKAA LAIWCPGYSE TQINATQAMK KRRKRKVTTN KCLEQVSQLQ GLWRRFNRPL LKQQ
- Purity
- > 85 % by SDS - PAGE
- Top Product
- Discover our top product TSLP Protein
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Comment
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Denatured
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 0.25 mg/mL
- Buffer
- Liquid. In 20 mM Tris-HCl buffer ( pH 8.0) containing 10 % Glycerol
- Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
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- Target
- Thymic Stromal Lymphopoietin (TSLP)
- Alternative Name
- TSLP (TSLP Products)
- Synonyms
- TSLP Protein, thymic stromal lymphopoietin Protein, TSLP Protein, Tslp Protein
- Background
- TSLP is a hemopoietic cytokine proposed to signal through a heterodimeric receptor complex composed of the thymic stromal lymphopoietin receptor and the IL-7R alpha chain. It mainly impacts myeloid cells and induces the release of T cell-attracting chemokines from monocytes and enhances the maturation of CD11c(+) dendritic cells. The protein promotes T helper type 2 (TH2) cell responses that are associated with immunity in various inflammatory diseases, including asthma, allergic inflammation and chronic obstructive pulmonary disease. TSLP is therefore considered a potential therapeutic target for the treatment of such diseases. Alternative splicing of this gene results in multiple transcript variants. Recombinant human TSLP protein, fused to His-tag at N-terminus, was expressed in E.coli.
- Molecular Weight
- 17.3kDa (154aa)
- NCBI Accession
- NP_149024
- UniProt
- Q969D9
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