GADD45A Protein (AA 1-165) (His tag)
Quick Overview for GADD45A Protein (AA 1-165) (His tag) (ABIN7505208)
Target
See all GADD45A ProteinsProtein Type
Origin
Source
Purity
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Protein Characteristics
- AA 1-165
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Purification tag / Conjugate
- This GADD45A protein is labelled with His tag.
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Sequence
- Met 1-Arg 165
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Characteristics
- A DNA sequence encoding the Human GADD45A protein (P24522 ) (1M-165R) was expressed with N-His tag.
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Growth Arrest and DNA-Damage-Inducible, alpha (GADD45A) (AA 1-165) protein (His tag)
custom-made GADD45A Origin: Mouse Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Growth Arrest and DNA-Damage-Inducible, alpha (GADD45A) (AA 1-165) protein (His tag)custom-made GADD45A Origin: Human Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Growth Arrest and DNA-Damage-Inducible, alpha (GADD45A) (AA 1-165) protein (GST tag)GADD45A Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Buffer
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Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization. -
Storage
- 4 °C,-20 °C,-80 °C
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Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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Expiry Date
- 12 months
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- GADD45A (Growth Arrest and DNA-Damage-Inducible, alpha (GADD45A))
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Alternative Name
- GADD45A
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Background
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Abbreviation: GADD45A
Target Synonym: Growth arrest and DNA damage-inducible protein GADD45 alpha,GADD45A,DNA damage-inducible transcript 1 protein,
Background: GADD45 alpha (Growth arrest and DNA damage-inducible protein 45 alpha) is a 19 kDa member of the GADD45 family of proteins. It is ubiquitously expressed, and induced by DNA damage. Upon induction, GADD45 alpha binds to PCNA, stimulates DNA excision repair, and initiates G2 cell cycle arrest. Human GADD45 alpha is 165 amino acids (aa) in length. It is reported to dimerize with GADD45-beta and -gamma, and to homo-dimerize, -trimerize and -tetramerize via residues 33?61 and 133?165. There is one splice variant that shows a Ser substitution for aa 14?49. GADD45 alpha is 55 % aa identical to GADD45-beta and -gamma, and shares 94 % aa identity with mouse GADD45 alpha.
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Molecular Weight
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Calculated MW: 18.04 kDa
Observed MW: 23 kDa
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UniProt
- P24522
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Pathways
- p53 Signaling, Cell Division Cycle
Target
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