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anti-Human CoREST Antibodies:
anti-Mouse (Murine) CoREST Antibodies:
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Mammalian Monoclonal CoREST Primary Antibody for ISt, IHC - ABIN1304608
Sáez, Gómez, Barrios, Parada, Galdames, González, Andrés: Decreased Expression of CoREST1 and CoREST2 Together with LSD1 and HDAC1/2 during Neuronal Differentiation. in PLoS ONE 2015
Show all 2 Pubmed References
Human Polyclonal CoREST Primary Antibody for IHC, WB - ABIN2780965
Battaglioli, Andrés, Rose, Chenoweth, Rosenfeld, Anderson, Mandel: REST repression of neuronal genes requires components of the hSWI.SNF complex. in The Journal of biological chemistry 2002
Show all 2 Pubmed References
the intact CoREST complex is targeted with dual histone deacetylase (show HDAC1 Antibodies) and demethylase (show MBD2 Antibodies) inhibitors
This study identified histone modification by SUMO as the first post-translational modification that stimulates intranucleosomal demethylation by the developmentally critical LSD1 (show KDM1A Antibodies)-CoREST complex.
results demonstrate that CoREST and LSD1 (show KDM1A Antibodies) downregulate the Notch (show NOTCH1 Antibodies) pathway in the developing cerebral cortex
ERalpha (show ESR1 Antibodies) engages not only LSD1 (show KDM1A Antibodies), but its partners of the CoREST corepressor complex and the molecular chaperone (show HSP90AA1 Antibodies) Hsp90 (show HSP90 Antibodies).
Expressions of REST and RCOR1 genes may downregulate SYN1 (show SYN1 Antibodies) expression in gliomas.
Rcor1 knock-out monocytes exhibited extensive self-renewal associated with hematopoietic stem cell expansion.
Data show that pregnane X receptor/retinoid X receptor PXR/RXR-[alpha], RXR-[beta], or RXR-[gamma] expression was noted in 9 (16.4%), 9 (16.4%), and 10 (18.2%) pancreatic adenocarcinoma cases, respectively.
The results suggest that LSD1 (show KDM1A Antibodies)/CoREST interacts with extranucleosomal DNA when it productively engages its nucleosome substrate.
results suggest that LSD1 (show KDM1A Antibodies)-CoREST functions as an ergonomic clamp (show PDZK1 Antibodies) that induces the detachment of the H3 histone (show HIST1H3B Antibodies) tail from the nucleosomal DNA to make it available for capture by the enzyme active site.
Genomic deletions in RCOR1 are associated with a specific gene expression signature and with unfavorable clinical outcomes in diffuse large B-cell lymphoma patients.
An INSM1 (show INSM1 Antibodies)/RCOR1 (show Rcor2 Antibodies)/2 complex controls the balance of proliferation and differentiation during brain development.
In mature erythroid cells, a strong upsurge in Rcor3 (show RCOR3 Antibodies) and a sharp decline in Rcor1 (show Rcor2 Antibodies) levels counteract LSD1 (show KDM1A Antibodies)/Rcor1 (show Rcor2 Antibodies)/2-mediated differentiation.
Rcor1 (show Rcor2 Antibodies) promotes erythropoiesis by repressing hematopoietic stem cells and/or progenitor genes, as well as the genes and signaling pathways that lead to myeloid cell fate.
This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the effects of retinoic acid (RA). The encoded protein forms homodimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. This gene lies within the major histocompatibility complex (MHC) class II region on chromosome 6. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
MHC class I promoter binding protein
, nuclear receptor subfamily 2 group B member 2
, retinoic acid receptor RXR-beta
, REST corepressor 1
, Mtfp1-like proline rich protein
, REST corepressor 1-like