anti-Rat (Rattus) CoREST antibody for Immunofluorescence

Recommended CoREST Antibody (supplied by: Log in to see )

Antigen
REST Corepressor 1 (RCOR1) Antibodies
  • COREST
  • RCOR
  • 5730409O11
  • 6720480E22Rik
  • AU042633
  • D12Wsu95e
  • mKIAA0071
  • rcor1
  • xcoREST
  • RCOR1
  • im:6904264
  • si:dkey-46n18.7
  • zgc:158607
  • RGD1305743
  • REST corepressor 1
  • REST corepressor 1 L homeolog
  • RCOR1
  • Rcor1
  • rcor1.L
  • rcor1
Epitope
AA 78-192
14
11
6
4
3
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
56
10
5
4
3
3
3
2
2
1
1
Host
Mouse
39
20
1
Clonality
Monoclonal
Conjugate
This CoREST antibody is un-conjugated
3
3
3
3
3
3
1
1
1
1
1
1
1
1
1
1
1
Application
Immunofluorescence (IF), Western Blotting (WB)
55
27
23
22
16
9
5
2
2
1
Options
Supplier
Log in to see
Supplier Product No.
Log in to see
Request

Get this product for free

Submit your validation data for this product and get a full refund. I want to validate this product

Learn more

Available images

Catalog No. ABIN968756
Contact our Customer Service for availability and price in your country.

General

Antigen REST Corepressor 1 (RCOR1) Antibodies
Epitope AA 78-192
(14), (11), (6), (4), (3), (1), (1)
Reactivity Human, Mouse (Murine), Rat (Rattus)
(56), (10), (5), (4), (3), (3), (3), (2), (2), (1), (1)
Host Mouse
(39), (20), (1)
Clonality (Clone)
Monoclonal   ( )
Conjugate This CoREST antibody is un-conjugated
(3), (3), (3), (3), (3), (3), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Immunofluorescence (IF), Western Blotting (WB)
(55), (27), (23), (22), (16), (9), (5), (2), (2), (1)
Pubmed 3 references available
Supplier Log in to see

Product Details anti-CoREST Antibody

Target Details CoREST Application Details Handling References for anti-CoREST antibody (ABIN968756) Images
Cross-Reactivity Mouse (Murine), Rat (Rattus)
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Immunogen Human CoREST aa. 78-192
Clone 26-CoRest
Isotype IgG1

Target Details CoREST

Product Details anti-CoREST Antibody Application Details Handling References for anti-CoREST antibody (ABIN968756) Images back to top
Antigen
Alternative Name CoRest (RCOR1 Antibody Abstract)
Background Histone deacetylases (HDACs) are found in large, multisubunit complexes. HDAC1 and HDAC2 are found predominately in either an mSin3A-containing complex or a complex containing the ATP-dependent chromatin remodeling protein, CHD4. The mSin3A complex is recrutied by DNA-binding transcription factors, such as the unligand hormone receptors. In these situations, the HDAC/mSin3A complex is thought to be involved in gene repression. CoREST is a corepressor for REST (RE1 silencing transcription factor) that is found in complex with mSin3A, as well as in non-mSin3A HDAC complexes. CoREST contains an N-terminal and a C-terminal SANT domain, which is common to corepressors involved in steroid horomone receptor gene repression. In non-neuronal cells, CoREST and REST mediate repression of the type II sodium channel promoter. REST is usually found in complex with mSin3A, and under certain conditions may recruit CoREST for repressor activity. The N-terminal SANT domain of CoREST is required for interaction with HDAC1 to form an HDAC complex that does not contain mSin3A or REST. Thus, CoREST is a corepressor that may interact with distinct protein complexes depending on the target for gene repression. This antibody is routinely tested by western blot analysis.
Molecular Weight 66 kDa
Pathways Regulation of Hormone Metabolic Process, Chromatin Binding

Application Details

Product Details anti-CoREST Antibody Target Details CoREST Handling References for anti-CoREST antibody (ABIN968756) Images back to top
Comment

Related Products: ABIN968537, ABIN967389

Restrictions For Research Use only

Handling

Product Details anti-CoREST Antibody Target Details CoREST Application Details References for anti-CoREST antibody (ABIN968756) Images back to top
Format Liquid
Concentration 250 μg/mL
Buffer Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store undiluted at -20° C.

References for anti-CoREST antibody (ABIN968756)

Product Details anti-CoREST Antibody Target Details CoREST Application Details Handling Images back to top
Product cited in:

You, Tong, Grozinger, Schreiber: "CoREST is an integral component of the CoREST- human histone deacetylase complex." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 98, Issue 4, pp. 1454-8, 2001

Grimes, Nielsen, Battaglioli, Miska, Speh, Berry, Atouf, Holdener, Mandel, Kouzarides: "The co-repressor mSin3A is a functional component of the REST-CoREST repressor complex." in: The Journal of biological chemistry, Vol. 275, Issue 13, pp. 9461-7, 2000

Andrés, Burger, Peral-Rubio, Battaglioli, Anderson, Grimes, Dallman, Ballas, Mandel: "CoREST: a functional corepressor required for regulation of neural-specific gene expression." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 96, Issue 17, pp. 9873-8, 1999

Images

Product Details anti-CoREST Antibody Target Details CoREST Application Details Handling References for anti-CoREST antibody (ABIN968756) back to top
Supplier Images
Western Blotting (WB) image for anti-REST Corepressor 1 (RCOR1) (AA 78-192) antibody (ABIN968756) Western blot analysis of CoREST on a Jurkat lysate. Lane 1: 1:250, lane 2: 1:500, lan...
Immunofluorescence (IF) image for anti-REST Corepressor 1 (RCOR1) (AA 78-192) antibody (ABIN968756) Immunofluorescence staining of PSFK-1 cells, a human primitive neuroectodermal tumor ...