anti-Human PDGFRA antibody for Immunohistochemistry (Paraffin-embedded Sections)

Recommended PDGFRA Antibody (supplied by: Log in to see )

Antigen
Platelet-Derived Growth Factor Receptor, alpha Polypeptide (PDGFRA) Antibodies
  • AI115593
  • CD140a
  • Pdgfr-2
  • APDGFR
  • PDGFACE
  • CD140A
  • PDGFR-2
  • PDGFR2
  • RHEPDGFRA
  • PDGFR
  • PDGFR-A
  • platelet derived growth factor receptor alpha
  • platelet derived growth factor receptor, alpha polypeptide
  • platelet-derived growth factor receptor, alpha polypeptide L homeolog
  • platelet-derived growth factor receptor, alpha polypeptide
  • PDGFRA
  • Pdgfra
  • pdgfra.L
Epitope
AA 698-727, Tyr720
36
22
20
19
18
18
17
17
16
15
15
15
15
13
12
12
12
10
10
10
7
7
6
5
5
5
5
4
4
4
4
4
3
3
3
3
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
489
275
180
6
6
6
5
5
3
3
3
2
2
1
1
1
1
Host
Rabbit
372
143
49
3
1
Clonality
Polyclonal
Conjugate
This PDGFRA antibody is un-conjugated
35
31
31
27
22
14
11
10
6
6
6
5
5
5
5
5
5
5
5
4
4
4
4
4
4
4
2
2
2
1
1
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
342
222
204
119
111
67
54
49
15
14
14
14
9
3
2
2
1
1
1
1
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Catalog No. ABIN392024
$ 335.50
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
11.600633 ABIN337400 ELISA IHC IHC (p) Rabbit IgG C-Term Log in to see Polyclonal 0
11.600633 ABIN784591 IHC (p) IP WB Rabbit IgG AA 1035-1053 Log in to see Polyclonal 0
11.600633 ABIN258822 IHC (p) IHC WB Mouse IgG1 N-Term Log in to see MM0004-8A89 0
11.600633 ABIN214662 ELISA IHC IHC (p) Rabbit AA 1063-1077 Log in to see Polyclonal 0
11.600633 ABIN461761 IHC IHC (p) Rabbit C-Term Log in to see Polyclonal 0
11.600633 ABIN5949588 FACS ICC IF IHC IHC (p) WB Rabbit IgG N-Term Log in to see JF104-6 0
11.600633 ABIN726620 IF (p) IHC (p) WB Rabbit IgG AA 1020-1070 Log in to see Polyclonal 1
11.600633 ABIN498160 IF IHC (p) WB Rabbit Log in to see Polyclonal 0
11.600633 ABIN710981 IF (p) IHC (p) WB Rabbit IgG pTyr762 Log in to see Polyclonal 0
1 ABIN3043897 IHC (p) WB Rabbit IgG AA 968-1002, C-Term Log in to see Polyclonal 0
1 ABIN392027 IHC (p) WB Rabbit Ig Fraction AA 746-775, Tyr768 Log in to see Polyclonal 5
1 ABIN392029 IHC (p) WB Rabbit Ig Fraction AA 732-761, Tyr754 Log in to see Polyclonal 5
1 ABIN392025 IHC (p) WB Rabbit Ig Fraction AA 740-769, Tyr762 Log in to see Polyclonal 5
1 ABIN3187792 ELISA IHC (p) WB Rabbit IgG Internal Region Log in to see Polyclonal 0
1 ABIN359906 EIA IHC (p) Rabbit Ig Fraction C-Term Log in to see Polyclonal 5
1 ABIN359912 EIA IHC (p) WB Rabbit Ig Fraction Tyr768 Log in to see Polyclonal 5
1 ABIN359914 EIA IF IHC (p) WB Rabbit Ig Fraction Tyr754 Log in to see Polyclonal 5
1 ABIN392022 FACS IHC (p) WB Rabbit Ig Fraction AA 1048-1077, C-Term Log in to see Polyclonal 1
1 ABIN790499 IHC IHC (p) IP WB Rabbit IgG AA 1035-1053 Log in to see Polyclonal 0
1 ABIN5611421 EIA IHC (p) Rabbit IgG C-Term Log in to see Polyclonal 0

General

Antigen Platelet-Derived Growth Factor Receptor, alpha Polypeptide (PDGFRA) Antibodies
Epitope AA 698-727, Tyr720
(36), (22), (20), (19), (18), (18), (17), (17), (16), (15), (15), (15), (15), (13), (12), (12), (12), (10), (10), (10), (7), (7), (6), (5), (5), (5), (5), (4), (4), (4), (4), (4), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Human
(489), (275), (180), (6), (6), (6), (5), (5), (3), (3), (3), (2), (2), (1), (1), (1), (1)
Host Rabbit
(372), (143), (49), (3), (1)
Clonality (Clone)
Polyclonal   ( )
Conjugate This PDGFRA antibody is un-conjugated
(35), (31), (31), (27), (22), (14), (11), (10), (6), (6), (6), (5), (5), (5), (5), (5), (5), (5), (5), (4), (4), (4), (4), (4), (4), (4), (2), (2), (2), (1), (1), (1)
Application Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(342), (222), (204), (119), (111), (67), (54), (49), (15), (14), (14), (14), (9), (3), (2), (2), (1), (1), (1), (1)
Pubmed 6 references available
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Product Details anti-PDGFRA Antibody

Target Details PDGFRA Application Details Handling References for anti-PDGFRA antibody (ABIN392024) Images
Specificity This PDGFRA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide corresponding to amino acid residues surrounding Y720 of human PDGFRA.
Predicted Reactivity Chicken,Mouse (Murine),Rat (Rattus),Xenopus laevis
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogen This PDGFRA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 698-727 AA from human PDGFRA.
Clone RB11101
Isotype Ig Fraction
Plasmids, Primers & others

Target Details PDGFRA

Product Details anti-PDGFRA Antibody Application Details Handling References for anti-PDGFRA antibody (ABIN392024) Images back to top
Antigen
Alternative Name PDGFRA (PDGFRA Antibody Abstract)
Background PDGFRA is a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies in knockout mice, where homozygosity is lethal, indicate that the alpha form of the platelet-derived growth factor receptor is particularly important for kidney development since mice heterozygous for the receptor exhibit defective kidney phenotypes.
Synonyms: PDGF-R-alpha, CD140a antigen, Alpha platelet-derived growth factor receptor
Molecular Weight 122669 DA
Gene ID 5156
NCBI Accession NP_006197
Pathways RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Platelet-derived growth Factor Receptor Signaling

Application Details

Product Details anti-PDGFRA Antibody Target Details PDGFRA Handling References for anti-PDGFRA antibody (ABIN392024) Images back to top
Application Notes WB = 1:1000, IHC (p) = 1:10-50
Restrictions For Research Use only

Handling

Product Details anti-PDGFRA Antibody Target Details PDGFRA Application Details References for anti-PDGFRA antibody (ABIN392024) Images back to top
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months

References for anti-PDGFRA antibody (ABIN392024)

Product Details anti-PDGFRA Antibody Target Details PDGFRA Application Details Handling Images back to top
Product cited in:

Guan, Wei, Wu, Fang, Liao, Xiao, Li, Li: "Down-regulation of miR-218-2 and its host gene SLIT3 cooperate to promote invasion and progression of thyroid cancer." in: The Journal of clinical endocrinology and metabolism, Vol. 98, Issue 8, pp. E1334-44, 2013 Method employed by authors: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Background publications

Wilczynski, Chen, Chen, Howell, Shively, Alberts: "Expression and mutational analysis of tyrosine kinase receptors c-kit, PDGFRalpha, and PDGFRbeta in ovarian cancers." in: Human pathology, Vol. 36, Issue 3, pp. 242-9, 2005

Hiwatari, Taki, Tsuchida, Hanada, Hongo, Sako, Hayashi: "Novel missense mutations in the tyrosine kinase domain of the platelet-derived growth factor receptor alpha(PDGFRA) gene in childhood acute myeloid leukemia with t(8;21)(q22;q22) or inv(16)(p13q22)." in: Leukemia, Vol. 19, Issue 3, pp. 476-7, 2005

Debiec-Rychter, Cools, Dumez, Sciot, Stul, Mentens, Vranckx, Wasag, Prenen, Roesel, Hagemeijer, Van Oosterom, Marynen: "Mechanisms of resistance to imatinib mesylate in gastrointestinal stromal tumors and activity of the PKC412 inhibitor against imatinib-resistant mutants." in: Gastroenterology, Vol. 128, Issue 2, pp. 270-9, 2005

Subramanian, West, Corless, Ou, Rubin, Chu, Leung, Yuen, Zhu, Hernandez-Boussard, Montgomery, Nielsen, Patel, Goldblum, Heinrich, Fletcher, van de Rijn: "Gastrointestinal stromal tumors (GISTs) with KIT and PDGFRA mutations have distinct gene expression profiles." in: Oncogene, Vol. 23, Issue 47, pp. 7780-90, 2004

Sakurai, Hasegawa, Sakuma, Takazawa, Motegi, Nakajima, Saito, Fukayama, Shimoda: "Myxoid epithelioid gastrointestinal stromal tumor (GIST) with mast cell infiltrations: a subtype of GIST with mutations of platelet-derived growth factor receptor alpha gene." in: Human pathology, Vol. 35, Issue 10, pp. 1223-30, 2004

Images

Product Details anti-PDGFRA Antibody Target Details PDGFRA Application Details Handling References for anti-PDGFRA antibody (ABIN392024) back to top
Supplier Images
Western Blotting (WB) image for anti-Platelet-Derived Growth Factor Receptor, alpha Polypeptide (PDGFRA) (AA 698-727), (Tyr720) antibody (ABIN392024) Western blot analysis of PDGFRA (arrow) using rabbit polyclonal PDGFRA Antibody (Y720...
Immunohistochemistry (IHC) image for anti-Platelet-Derived Growth Factor Receptor, alpha Polypeptide (PDGFRA) (AA 698-727), (Tyr720) antibody (ABIN392024) Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with PDGFRA...
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Platelet-Derived Growth Factor Receptor, alpha Polypeptide (PDGFRA) (AA 698-727), (Tyr720) antibody (ABIN392024) ABIN392024,ABIN2841799 staining PDGFRA in Human hepatic carcinoma tissue sections by ...
Western Blotting (WB) image for anti-Platelet-Derived Growth Factor Receptor, alpha Polypeptide (PDGFRA) (AA 698-727), (Tyr720) antibody (ABIN392024) Anti-PDGFRA-pY720. ctrlat 1:1000 dilution + human platelet lysates Lysates/proteins a...