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anti-Human CDC42 Antibodies:
anti-Mouse (Murine) CDC42 Antibodies:
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X-ray crystallography reveals that in addition to the canonical PAK4 (show PAK4 Antibodies) CDC42/RAC (show AKT1 Antibodies) interactive binding (CRIB (show SCRIB Antibodies)) domain binding to CDC42 there are unexpected contacts involving the PAK4 (show PAK4 Antibodies) kinase C-lobe, CDC42, and the PAK4 (show PAK4 Antibodies) polybasic region.
Cdc42 plays a role in regulating the proliferation of PMVECs stimulated with small doses of LPS (show IRF6 Antibodies), and this regulation involves the ERK (show EPHB2 Antibodies) pathway
Data show that Ras-like without CAAX 1 (show RIT1 Antibodies) protein (RIT1 (show RIT1 Antibodies)) binds the RHO GTPases CDC42 and RAC1, both of which are crucial regulators of actin dynamics upstream of PAK1 (show PAK1 Antibodies).
The results show that PTEN controls multicellular assembly through a membrane-associated regulatory protein complex composed of beta-Arrestin1 (show ARRB1 Antibodies), ARHGAP21 (show ARHGAP21 Antibodies) and Cdc42.
CDC42 acts as an essential factor in regulating cell proliferation and also takes part in lipotoxic effects of palmitate.
loss of XIAP enhances filopodia formation in a Cdc42-dependent manner and this phenomenon phenocopies EGF stimulation. Further, XIAP depletion promotes lung colonization of tumor cells in mice in a Cdc42-dependent manner. These observations shed molecular insights into ubiquitin-dependent regulation of Cdc42 and that of actin cytoskeleton.
Cdc42 can affect multiple morphogenetic processes during angiogenic sprouting and ultimately impact the architecture of the vasculature.
Study identified different phenotypic correlations of nuclear versus cytoplasmic expression of CDC42, with high nuclear expression correlating with better prognostic features. These results show that CDC42 seems to be a key determinant of low-grade ER-positive breast cancers with prognostic significance. Subcellular localization may be important in determining breast cancer morphology.
Downregulation of PLEKHA7 (show PLEKHA7 Antibodies) in PACG may affect BAB (show RERE Antibodies) integrity and aqueous humor outflow via its Rac1/Cdc42 GAP activity, thereby contributing to disease etiology.
CDC42 has an active oncogenic role in CRC (show CALR Antibodies) via the transcriptional regulation of multiple cancer-related pathways and that CDC42-mediated silencing of CACNA2D2 (show CACNA2D2 Antibodies) is clinically relevant.
Cdc42 is required for endothelial tip cell selection, directed cell migration and filopodia formation, but dispensable for cell proliferation or apoptosis. Although the loss of Cdc42 seems generally compatible with apical-basal polarization and lumen formation in retinal blood vessels
Cdc42 bypasses the need for exogenous fibronectin (show FN1 Antibodies) by stimulating cellular fibronectin (show FN1 Antibodies) deposition under the newly formed lamellipodia.
Simulated microgravity activates Cdc42 via Rap1GDS1 (show RAP1GDS1 Antibodies) to promote vascular branch morphogenesis.
In contrast to neuronal cells, Botulinum neurotoxin type B (show BoNT/B Antibodies) uses a Cdc42-dependent pathway to enter intestinal cells.
We conclude that CRN7 spatiotemporally influences F-actin organization and Golgi integrity in a Cdc42- and N-WASP-dependent manner.
the expression of CDC42 might be regulated by AHR (show AHR Antibodies), and both proteins are fundamental to the development of normal spermatozoa and the acrosome reaction.
CDC42 loss suppresses acute myeloid leukemia (show BCL11A Antibodies) cell polarity and division asymmetry.
CDC42 is involved in the trafficking of FGF receptors to the cell membrane to regulate epicardium formation.
LRCH1 (show LRCH1 Antibodies) as a novel effector to restrain PKCalpha (show PKCa Antibodies)-DOCK8 (show DOCK8 Antibodies)-Cdc42 module-induced T cell migration and ameliorate experimental autoimmune encephalomyelitis (EAE).
analysis of phenotypes of Cdc42 and Myo10 (show MYO10 Antibodies) deletion that show multiple roles of filopodial dynamics
Knockdown of fat1 (show FAT1 Antibodies) in zebrafish causes pronephric cysts, which is partially rescued by RAC1/CDC42 activators, confirming a role of the two small GTPases in the pathogenesis.
Cdc42 deficiency causes ciliary abnormalities and cystic kidneys.
Cdc42 GTPase (show RACGAP1 Antibodies) and Rac1 GTPase (show RACGAP1 Antibodies) act downstream of p120 catenin (show CTNND1 Antibodies) and require GTP (show AK3 Antibodies) exchange during gastrulation of zebrafish mesoderm.
These results suggest that Ptenb by antagonizing PI3 kinase and its downstream Akt1 and Cdc42 to regulate actin polymerization that is critical for proper cell motility and migration control during gastrulation in zebrafish.
The protein encoded by this gene is a small GTPase of the Rho-subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. This protein is highly similar to Saccharomyces cerevisiae Cdc 42, and is able to complement the yeast cdc42-1 mutant. The product of oncogene Dbl was reported to specifically catalyze the dissociation of GDP from this protein. This protein could regulate actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. Alternative splicing of this gene results in multiple transcript variants. Pseudogenes of this gene have been identified on chromosomes 3, 4, 5, 7, 8 and 20.
G25K GTP-binding protein
, GTP binding protein, 25kDa
, GTP-binding protein, 25kD
, cell division control protein 42 homolog
, dJ224A6.1.1 (cell division cycle 42 (GTP-binding protein, 25kD))
, dJ224A6.1.2 (cell division cycle 42 (GTP-binding protein, 25kD))
, growth-regulating protein
, small GTP binding protein CDC42
, cell division cycle 42 homolog
, Cdc42 protein homolog
, cell division cycle 42
, Rho family small GTP binding protein cdc42