anti-Rat (Rattus) TNFAIP3 antibody for Immunofluorescence (Paraffin-embedded Sections)

Recommended TNFAIP3 Antibody (supplied by: Log in to see )

Antigen
Tumor Necrosis Factor, alpha-Induced Protein 3 (TNFAIP3) Antibodies
  • tnfaip3
  • MGC82339
  • TNFAIP3
  • A20
  • OTUD7C
  • TNFA1P2
  • Tnfip3
  • TNF alpha induced protein 3
  • TNF alpha induced protein 3 S homeolog
  • tumor necrosis factor, alpha-induced protein 3
  • TNFAIP3
  • tnfaip3.S
  • Tnfaip3
Epitope
AA 80-103
35
14
5
4
3
2
2
2
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
103
67
64
6
2
1
1
Host
Rabbit
72
25
6
Clonality
Polyclonal
Conjugate
This TNFAIP3 antibody is un-conjugated
4
4
3
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
74
37
36
31
29
27
19
12
10
6
3
2
2
2
Options
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Catalog No. ABIN680938
$ 306.90
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
1 ABIN918067 IF (p) Alexa Fluor 555 Rabbit IgG AA 80-103 Log in to see Polyclonal 0
1 ABIN918070 IF (p) Alexa Fluor 350 Rabbit IgG AA 80-103 Log in to see Polyclonal 0
1 ABIN918069 IF (p) Alexa Fluor 647 Rabbit IgG AA 80-103 Log in to see Polyclonal 0
1 ABIN918066 IF (p) Alexa Fluor 488 Rabbit IgG AA 80-103 Log in to see Polyclonal 0
1 ABIN680941 IF (p) Cy3 Rabbit IgG AA 80-103 Log in to see Polyclonal 0
1 ABIN680942 IF (p) Cy5 Rabbit IgG AA 80-103 Log in to see Polyclonal 0
1 ABIN680943 IF (p) Cy5.5 Rabbit IgG AA 80-103 Log in to see Polyclonal 0
1 ABIN680945 IF (p) FITC Rabbit IgG AA 80-103 Log in to see Polyclonal 0
1 ABIN680944 IF (p) Cy7 Rabbit IgG AA 80-103 Log in to see Polyclonal 0
1 ABIN2814996 IF (p) Alexa Fluor 594 Rabbit IgG AA 80-103 Log in to see Polyclonal 0
1 ABIN5011750 IF (p) Alexa Fluor 750 Rabbit IgG AA 80-103 Log in to see Polyclonal 0
1 ABIN5011749 IF (p) Alexa Fluor 680 Rabbit IgG AA 80-103 Log in to see Polyclonal 0

General

Antigen Tumor Necrosis Factor, alpha-Induced Protein 3 (TNFAIP3) Antibodies
Epitope AA 80-103
(35), (14), (5), (4), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Human, Mouse (Murine), Rat (Rattus)
(103), (67), (64), (6), (2), (1), (1)
Host Rabbit
(72), (25), (6)
Clonality
Polyclonal
Conjugate This TNFAIP3 antibody is un-conjugated
(4), (4), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(74), (37), (36), (31), (29), (27), (19), (12), (10), (6), (3), (2), (2), (2)
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Product Details anti-TNFAIP3 Antibody

Target Details TNFAIP3 Application Details Handling Images
Purification Purified by Protein A.
Immunogen KLH conjugated synthetic peptide derived from human TNFAIP3
Isotype IgG
Plasmids, Primers & others

Target Details TNFAIP3

Product Details anti-TNFAIP3 Antibody Application Details Handling Images back to top
Antigen
Alternative Name Tnfaip3 (TNFAIP3 Antibody Abstract)
Background

Ubiquitin-editing enzyme that contains both ubiquitin ligase and deubiquitinase activities. Involved in immune and inflammatory responses signaled by cytokines, such as TNF-alpha and IL-1 beta, or pathogens via Toll-like receptors (TLRs) through terminating NF-kappa-B activity. Essential component of a ubiquitin-editing protein complex, comprising also RNF11, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. In cooperation with TAX1BP1 promotes disassembly of E2-E3 ubiquitin protein ligase complexes in IL-1R and TNFR-1 pathways, affected are at least E3 ligases TRAF6, TRAF2 and BIRC2, and E2 ubiquitin-conjugating enzymes UBE2N and UBE2D3. In cooperation with TAX1BP1 promotes ubiquitination of UBE2N and proteasomal degradation of UBE2N and UBE2D3. Upon TNF stimulation, deubiquitinates 'Lys-63'-polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B. Deubiquitinates TRAF6 probably acting on 'Lys-63'-linked polyubiquitin. Upon T-cell receptor (TCR)-mediated T-cell activation, deubiquitinates 'Lys-63'-polyubiquitin chains on MALT1 thereby mediating disassociation of the CBM (CARD11:BCL10:MALT1) and IKK complexes and preventing sustained IKK activation. Deubiquitinates NEMO/IKBKG, the function is facilitated by TNIP1 and leads to inhibition of NF-kappa-B activation. Upon stimulation by bacterial peptidoglycans, probably deubiquitinates RIPK2. Can also inhibit I-kappa-B-kinase (IKK) through a non-catalytic mechanism which involves polyubiquitin, polyubiquitin promotes association with IKBKG and prevents IKK MAP3K7-mediated phosphorylation. Targets TRAF2 for lysosomal degradation. In vitro able to deubiquitinate 'Lys-11'-, 'Lys-48'- and 'Lys-63' polyubiquitin chains. Inhibitor of programmed cell death.

Subcellular location: Cytoplasm, Nucleus, Lysosome

Synonyms: A20, OTUD7C, TNFA1P2, Tumor necrosis factor alpha-induced protein 3, TNF alpha-induced protein 3, OTU domain-containing protein 7C, Putative DNA-binding protein A20, Zinc finger protein A20, TNFAIP3

Gene ID 7128
UniProt P21580
Pathways TLR Signaling, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Production of Molecular Mediator of Immune Response

Application Details

Product Details anti-TNFAIP3 Antibody Target Details TNFAIP3 Handling Images back to top
Application Notes WB 1:100-1000
IHC-P 1:100-500
IF(IHC-P) 1:50-200
Restrictions For Research Use only

Handling

Product Details anti-TNFAIP3 Antibody Target Details TNFAIP3 Application Details Images back to top
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20°C
Expiry Date 12 months

Images

Product Details anti-TNFAIP3 Antibody Target Details TNFAIP3 Application Details Handling back to top
Supplier Images
Immunohistochemistry (IHC) image for anti-Tumor Necrosis Factor, alpha-Induced Protein 3 (TNFAIP3) (AA 80-103) antibody (ABIN680938) Formalin-fixed and paraffin embedded rat myocardium labeled with Anti-TNFAIP3 Polyclo...
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Tumor Necrosis Factor, alpha-Induced Protein 3 (TNFAIP3) (AA 80-103) antibody (ABIN680938) Formalin-fixed and paraffin embedded human lung carcinoma labeled with Rabbit Anti TN...