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Submit your validation data for this product and get a full refund. I want to validate this productRelevance Score | ABIN | Application | Conjugate | Host | Isotype | Epitope | Supplier | Clonality | References | Details |
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15.863943 | ABIN6265632 | ELISA ICC IF IHC WB | Rabbit | IgG | Log in to see | Polyclonal | 0 | |||
10 | ABIN1875125 | ICC IF IHC WB | Rabbit | IgG | Log in to see | Polyclonal | 0 | |||
9.863943 | ABIN604690 | ELISA IHC IHC (p) WB | Rabbit | IgG | C-Term | Log in to see | Polyclonal | 0 | ||
9.863943 | ABIN1030759 | IHC ELISA WB | Rabbit | C-Term | Log in to see | Polyclonal | 0 | |||
9.863943 | ABIN1031138 | IHC ELISA WB | Rabbit | Middle Region | Log in to see | Polyclonal | 0 | |||
5.5 | ABIN6673436 | IHC WB | Rabbit | IgG | Log in to see | Polyclonal | 1 | |||
4 | ABIN478080 | IHC ELISA WB | Rabbit | IgG | Internal Region | Log in to see | Polyclonal | 0 | ||
1 | ABIN2574921 | ICC IF IHC IHC (p) WB | Rabbit | Internal Region | Log in to see | Polyclonal | 0 | |||
1 | ABIN2880119 | ICC IF IHC WB | Rabbit | IgG | Log in to see | Polyclonal | 0 | |||
1 | ABIN2894550 | IHC WB | Rabbit | Log in to see | Polyclonal | 0 | ||||
1 | ABIN1887667 | IHC ELISA WB | Rabbit | Center | Log in to see | Polyclonal | 0 | |||
1 | ABIN1886989 | IHC ELISA WB | Rabbit | C-Term | Log in to see | Polyclonal | 0 | |||
1 | ABIN2902986 | ELISA IHC WB | Rabbit | IgG | Log in to see | Polyclonal | 0 | |||
1 | ABIN1994956 | IHC WB | Rabbit | IgG | Log in to see | 0 | ||||
-0.92909527 | ABIN4277012 | ELISA ICC IF IHC IHC (p) WB | Rabbit | Center | Log in to see | Polyclonal | 0 | |||
-3.9290953 | ABIN4277013 | ELISA ICC IF IHC IHC (p) WB | Rabbit | C-Term | Log in to see | Polyclonal | 0 |
General |
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Antigen | Tumor Necrosis Factor, alpha-Induced Protein 3 (TNFAIP3) Antibodies |
Reactivity | Mouse (Murine), Rat (Rattus), Human Alternatives |
Host | Rabbit Alternatives |
Clonality | |
Conjugate | This TNFAIP3 antibody is un-conjugated Alternatives |
Application |
Immunohistochemistry (IHC), Western Blotting (WB)
Alternatives
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1 reference available |
Supplier | Log in to see |
Product Details anti-TNFAIP3 AntibodyTarget Details TNFAIP3 Application Details Handling References for anti-TNFAIP3 antibody (ABIN3022985) Images |
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Purification | Affinity purification |
Immunogen | Recombinant protein of human TNFAIP3 |
Isotype | IgG |
Plasmids, Primers & others | |
Target Details TNFAIP3Product Details anti-TNFAIP3 Antibody Application Details Handling References for anti-TNFAIP3 antibody (ABIN3022985) Images back to top |
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Antigen | |
Alternative Name | TNFAIP3 (TNFAIP3 Antibody Abstract) |
Background |
A20, also referred to as TNF-alpha-induced protein 3 (TNFAIP3), is cytokine-inducible protein that functions to inhibit apoptosis and activate NF-kappaB. It was first identified as a TNF-alpha inducible primary response gene in human umbilical vein endothelial cells, and encodes a 790 AA protein containing seven Cys2/Cys2-zinc finger motifs. Constitutive expression of A20 is observed in lymphoid tissues , but it is transiently expressed in a variety of cell types in response to inflammatory signals such as TNF-alpha , IL-1 , phorbol esters , and LPS. Expression of A20 can confer resistance to apoptosis and NF-kappaB activation triggered by these signals, probably through interference with TRAF (TNF receptor associated factor) family members , and interaction with the NF-kappaB inhibiting protein ABIN. Studies also show that A20 contains site-specific ubiquitin modifying activity that can contribute to its biological functions. The amino-terminus of A20 contains de-ubiquitinating (DUB) activity for Lys63 branches, such as those found in TRAF6 and RIP, while the carboxyl-terminus contains ubiquitin ligase (E3) activity for Lys48 branches of the same substrates and leads to their degradation. Synonyms: A20, MGC104522, MGC138687, MGC138688, OTUD7C, TNFA1P2 |
Gene ID | 7128 |
UniProt | P21580 |
Pathways | TLR Signaling, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Production of Molecular Mediator of Immune Response |
Application DetailsProduct Details anti-TNFAIP3 Antibody Target Details TNFAIP3 Handling References for anti-TNFAIP3 antibody (ABIN3022985) Images back to top |
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Application Notes | Recommended dilutions: WB: 1:500-1:2000, IHC: 1:50-1:200 |
Restrictions | For Research Use only |
HandlingProduct Details anti-TNFAIP3 Antibody Target Details TNFAIP3 Application Details References for anti-TNFAIP3 antibody (ABIN3022985) Images back to top |
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Format | Liquid |
Buffer | PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3 |
Preservative | Sodium azide |
Precaution of Use | This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only. |
Handling Advice | Avoid freeze / thaw cycles |
Storage | -20 °C/-80 °C |
References for anti-TNFAIP3 antibody (ABIN3022985)Product Details anti-TNFAIP3 Antibody Target Details TNFAIP3 Application Details Handling Images back to top |
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Product cited in: |
He, Ma, Tian, Wei, Zhu, Li, Zhang, Wang, Zhang, Zhong: "ERRα negatively regulates type I interferon induction by inhibiting TBK1-IRF3 interaction." in: PLoS pathogens, Vol. 13, Issue 6, pp. e1006347, 2017 Method employed by authors: Western Blotting (WB) |
ImagesProduct Details anti-TNFAIP3 Antibody Target Details TNFAIP3 Application Details Handling References for anti-TNFAIP3 antibody (ABIN3022985) back to top |
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Supplier Images |