anti-MDS1 and EVI1 Complex Locus (MECOM) Antibodies

The protein encoded by MECOM is a transcriptional regulator and oncoprotein that may be involved in hematopoiesis, apoptosis, development, and cell differentiation and proliferation. Additionally we are shipping MDS1 and EVI1 Complex Locus Proteins (8) and MDS1 and EVI1 Complex Locus Kits (2) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
MECOM 2122 Q03112 , Q13465
MECOM 14013 Q9Z1L8
MECOM 294924  
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top anti-MDS1 and EVI1 Complex Locus Antibodies at antibodies-online.com

Showing 10 out of 118 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated IHC, WB Host: Rabbit Target Name: EVI1 Sample Tissue: Human 293T Antibody Dilution: 1.0ug/ml Host: Rabbit Target Name: MECOM Sample Tissue: Human 293T Whole Cell Antibody Dilution: 1ug/ml 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB WB Suggested Anti-EVI1 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:1562500 Positive Control: Human brain 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-EVI1 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:62500Positive Control: Hela cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB WB Suggested Anti-MDS1 Antibody Titration: 1.25ug/mlELISA Titer: 1:312500Positive Control: Raji cell lysate WB Suggested Anti-MDS1  Antibody Titration: 1.25 µg/mL ELISA Titer: 1:312500  Positive Control: Raji cell lysate 100 μL Log in to see 2 to 3 Days
$229.00
Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of EVI1 Antibody (N-term) in CEM cell line lysates (35ug/lane). This demonstrates the EVI1 antibody detected the EVI1 protein (arrow). 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of MDS1 Antibody (Center) in mouse NIH-3T3 cell line lysates (35ug/lane). This demonstrates the MDS1 antibody detected the MDS1 protein (arrow). 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Mouse Un-conjugated EIA, WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Goat Un-conjugated ELISA, WB Western Blot: EVI1 Antibody [NBP1-68842] - Analysis of EVI1 in A549 lysate (35ug protein in RIPA buffer) using NBP1-68842 at 2ug/ml. Primary incubation was 1 hour. Detected by chemiluminescence. 0.1 mg Log in to see 7 to 9 Days
$408.19
Details
Human Rabbit Un-conjugated ELISA, IHC, WB 100 μL Log in to see 16 Days
$175.80
Details
Human Mouse Un-conjugated WB Western analysis of extracts from 293 cells using PRDM3 antibody. 400 μL Log in to see 10 to 11 Days
$324.50
Details

MECOM Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Human , , , ,
, ,
,
, , , , ,
Mouse (Murine)
,
,
, , , , ,
Rat (Rattus)


Top referenced anti-MDS1 and EVI1 Complex Locus Antibodies

  1. Human Polyclonal MECOM Primary Antibody for EIA, WB - ABIN953364 : Goyama, Kurokawa: Evi-1 as a critical regulator of leukemic cells. in International journal of hematology 2010 (PubMed)
    Show all 2 references for 953364

  2. Human Polyclonal MECOM Primary Antibody for EIA, WB - ABIN952135 : Gómez-Benito, Conchillo, García, Vázquez, Maicas, Vicente, Cristobal, Marcotegui, García-Ortí, Bandrés, Calasanz, Alonso, Odero: EVI1 controls proliferation in acute myeloid leukaemia through modulation of miR-1-2. in British journal of cancer 2010 (PubMed)
    Show all 2 references for 952135

  3. Human Polyclonal MECOM Primary Antibody for ELISA, WB - ABIN4270672 : Konrad, Karger, Hackl, Schwarzinger, Herbacek, Wieser: Inducible expression of EVI1 in human myeloid cells causes phenotypes consistent with its role in myelodysplastic syndromes. in Journal of leukocyte biology 2009 (PubMed)

  4. Cow (Bovine) Polyclonal MECOM Primary Antibody for WB - ABIN2787657 : Sato, Goyama, Nitta, Takeshita, Yoshimi, Nakagawa, Kawazu, Ichikawa, Kurokawa: Evi-1 promotes para-aortic splanchnopleural hematopoiesis through up-regulation of GATA-2 and repression of TGF-b signaling. in Cancer science 2008 (PubMed)

  5. Cow (Bovine) Polyclonal MECOM Primary Antibody for IHC, WB - ABIN2777403 : Chi, Senyuk, Chakraborty, Nucifora: EVI1 promotes cell proliferation by interacting with BRG1 and blocking the repression of BRG1 on E2F1 activity. in The Journal of biological chemistry 2003 (PubMed)

  6. Human Polyclonal MECOM Primary Antibody for WB - ABIN2780631 : Fears, Mathieu, Zeleznik-Le, Huang, Rowley, Nucifora: Intergenic splicing of MDS1 and EVI1 occurs in normal tissues as well as in myeloid leukemia and produces a new member of the PR domain family. in Proceedings of the National Academy of Sciences of the United States of America 1996 (PubMed)

More Antibodies against MDS1 and EVI1 Complex Locus Interaction Partners

Zebrafish MDS1 and EVI1 Complex Locus (MECOM) interaction partners

  1. nephrogenesis in zebrafish is regulated by interactions between retinoic acid, mecom, and Notch (show NOTCH1 Antibodies) signaling

  2. Prdm3 and prdm16 (show PRDM16 Antibodies) are strongly expressed in the pharyngeal arches during cranioskeletal development, and their knockdown leads to defects in both the viscerocranium and the neurocranium.

Human MDS1 and EVI1 Complex Locus (MECOM) interaction partners

  1. Heterozygous germ line mutations in the RUNX1 (show RUNX1 Antibodies) gene are responsible genetic events for FPD/AML (show RUNX1 Antibodies).

  2. Data suggest that RUNX1 (show RUNX1 Antibodies) pays dual roles in normal female sexual development/maturation and tumorigenesis in female-related cancers; "alterations" in RUNX1 (show RUNX1 Antibodies), either mutations in RUNX1 (show RUNX1 Antibodies) gene or variations in expression of RUNX1 (show RUNX1 Antibodies), appear to be associated with breast, ovarian, uterine, and cervical neoplasms. [REVIEW]

  3. The E3 ubiquitin ligase (show MUL1 Antibodies) STUB1 (show STUB1 Antibodies) is a negative regulator of both RUNX1 (show RUNX1 Antibodies) and RUNX1 (show RUNX1 Antibodies)-RUNX1T1 (show RUNX1T1 Antibodies). Activation of STUB1 (show STUB1 Antibodies) could be a promising therapeutic strategy for RUNX1 (show RUNX1 Antibodies)-RUNX1T1 (show RUNX1T1 Antibodies) leukemia.

  4. The clinical significance of ETV6 (show ETV6 Antibodies)-RUNX1 (show RUNX1 Antibodies).

  5. Deliver the necessary promotional drive for the progression of ETV6 (show ETV6 Antibodies)-RUNX1 (show RUNX1 Antibodies)+ pre-leukaemic cells.

  6. High RUNX1 (show RUNX1 Antibodies) expression is associated with pancreatic cancer.

  7. these findings have identified a novel function for Runx1 (show RUNX1 Antibodies) in sustaining normal mammary epithelial morphology and preventing epithelial-mesenchymal transition

  8. Leukaemogenesis by AML1 (show RUNX1 Antibodies)-ETO (show RUNX1T1 Antibodies) requires enhanced C/D box snoRNA/RNP (show RNPC3 Antibodies) formation.

  9. The expression of EVI1 and SOX9 (show SOX9 Antibodies) is associated with stem cell-like and metastasis signatures, and their depletion impairs the metastatic potential of breast cancer cells. These results establish the mechanistic link between resistance to mTOR (show FRAP1 Antibodies) inhibition and cancer metastatic potential, thus enhancing our understanding of mTOR (show FRAP1 Antibodies) targeting failure

  10. In this study, we found upregulation of several hemostasis-related genes, including the thrombin (show F2 Antibodies)-activatable receptor PAR-1 (protease-activated receptor-1 (show F2R Antibodies)), in Runx1 (show RUNX1 Antibodies)/Cbfb (show CBFB Antibodies)-deleted MLL (show MLL Antibodies)-AF9 (show MLLT3 Antibodies) cells. Similar to the effect of Runx1 (show RUNX1 Antibodies)/Cbfb (show CBFB Antibodies) deletion, PAR-1 (show MARK2 Antibodies) overexpression induced CDKN1A/p21 (show CDKN1A Antibodies) expression and attenuated proliferation in MLL (show MLL Antibodies)-AF9 (show MLLT3 Antibodies) cells

Mouse (Murine) MDS1 and EVI1 Complex Locus (MECOM) interaction partners

  1. Gata2 (show GATA2 Antibodies) heterozygous deletion confers selective advantage to EVI1-expressing leukemia cell expansion in recipient mice

  2. EVI1 acts as a regulator of its own expression, highlighting the complex regulation of EVI1, and open new directions to better understand the mechanisms of EVI1 overexpressing leukemias.

  3. the DNA sequences to which EVI1 binds at +35 and +37 kb and show that mutation of one of these releases Cebpa (show CEBPA Antibodies) from EVI1-induced suppression.

  4. Evi1(+)DA-3 cells modified to express an intracellular form of GM-CSF (show CSF2 Antibodies), acquired growth factor independence and transplantability and caused an overt leukemia in syngeneic hosts, without increasing serum GM-CSF (show CSF2 Antibodies) levels.

  5. Survivin (show BIRC5 Antibodies) partially regulates HSC (show FUT1 Antibodies) function by modulating the Evi-1 transcription factor and its downstream targets

  6. Thrombopoietin (show THPO Antibodies)/MPL (show MPL Antibodies) signaling confers growth and survival capacity to CD41-positive cells in a mouse model of Evi1 leukemia.

  7. Prdm16 (show PRDM16 Antibodies) and Prdm3 control postnatal BAT (show BAAT Antibodies) identity and function.

  8. Mice carrying a hypomorphic Evi1 allele are embryonic viable but exhibit severe congenital heart defects.

  9. PR-domain protein ME has an essential role in mixed-lineage leukemia (MLL (show MLL Antibodies)) fusion protein (MFP) leukemia

  10. Cotransduction of Evi1 and the shortest isoform of C/EBPbeta (show CEBPB Antibodies), liver inhibitory protein (LIP), induced acute myeloid leukemia (show BCL11A Antibodies) with short latencies in a mouse bone marow transplantation model.

MDS1 and EVI1 Complex Locus (MECOM) Antigen Profile

Protein Summary

Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. The protein encoded by this gene represents the alpha subunit of CBF and is thought to be involved in the development of normal hematopoiesis. Chromosomal translocations involving this gene are well-documented and have been associated with several types of leukemia. Three transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with MECOM

  • MDS1 and EVI1 complex locus (mecom) antibody
  • MDS1 and EVI1 complex locus (MECOM) antibody
  • MDS1 and EVI1 complex locus (LOC100343228) antibody
  • MDS1 and EVI1 complex locus (Mecom) antibody
  • runt-related transcription factor 1 (RUNX1) antibody
  • AML1 antibody
  • AML1-EVI-1 antibody
  • AMLCR1 antibody
  • CBFA2 antibody
  • D630039M04Rik antibody
  • EVI-1 antibody
  • Evi1 antibody
  • im:7140716 antibody
  • Jbo antibody
  • Mds antibody
  • Mds1 antibody
  • Mds1-Evi1 antibody
  • PEBP2aB antibody
  • Prdm3 antibody
  • Znfpr1b1 antibody

Protein level used designations for MECOM

ecotropic viral integration site 1 , PR domain containing 3 , MDS1 and EVI1 complex locus , MDS1 and EVI1 complex locus protein EVI1-like , AML1-EVI-1 fusion protein , MDS1 and EVI1 complex locus protein EVI1 , MDS1 and EVI1 complex locus protein MDS1 , ecotropic virus integration site 1 protein homolog , myelodysplasia syndrome-associated protein 1 , oncogene EVI1 , zinc finger protein Evi1 , ecotropic virus integration site 1 protein , myelodysplasia syndrome 1 homolog , myelodysplasia syndrome 1 protein homolog , CBF-alpha-2 , PEA2-alpha B , PEBP2-alpha B , SL3-3 enhancer factor 1 alpha B subunit , SL3/AKV core-binding factor alpha B subunit , acute myeloid leukemia 1 protein , core-binding factor, runt domain, alpha subunit 2 , oncogene AML-1 , polyomavirus enhancer-binding protein 2 alpha B subunit

GENE ID SPECIES
497407 Danio rerio
460837 Pan troglodytes
698603 Macaca mulatta
100343228 Oryctolagus cuniculus
100403987 Callithrix jacchus
100591579 Nomascus leucogenys
2122 Homo sapiens
14013 Mus musculus
424997 Gallus gallus
488148 Canis lupus familiaris
532209 Bos taurus
294924 Rattus norvegicus
861 Homo sapiens
Selected quality suppliers for anti-MDS1 and EVI1 Complex Locus (MECOM) Antibodies
Did you look for something else?