anti-SUZ12 Polycomb Repressive Complex 2 Subunit (SUZ12) Antibodies

SUZ12 encodes a core component of the polycomb repressive complex 2 (PRC2) that also includes, at least, embryonic ectoderm development protein (EED) and enhancer of zeste homolog 1 or 2 (EZH1 or EZH2). Additionally we are shipping SUZ12 Polycomb Repressive Complex 2 Subunit Kits (6) and SUZ12 Polycomb Repressive Complex 2 Subunit Proteins (5) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SUZ12 688041  
SUZ12 52615 Q80U70
SUZ12 23512 Q15022
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Top anti-SUZ12 Polycomb Repressive Complex 2 Subunit Antibodies at antibodies-online.com

Showing 10 out of 103 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-SUZ12 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:312500  Positive Control:  721_B cell lysate SUZ12 is strongly supported by BioGPS gene expression data to be expressed in Human 721_B cells 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated ChIP, IHC, WB Chromatin Immunoprecipitation (ChIP) Using SUZ12 antibody - middle region  and HCT116 Cells 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Mouse Un-conjugated ELISA, FACS, WB Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng) Western blot analysis using SUZ12 mAb against human SUZ12 (AA: 1-139) recombinant protein. (Expected MW is 39.9 kDa) 0.1 mg Log in to see 8 to 11 Days
$577.50
Details
Human Mouse Un-conjugated ELISA, FACS, IHC, WB ELISA: SUZ12 Antibody (2B9G12)  - Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng) Flow Cytometry: SUZ12 Antibody (2B9G12)  - Analysis of Hela cells using SUZ12 mouse mAb (green) and negative control (red). 0.1 mL Log in to see 7 to 9 Days
$516.98
Details
Bat Rabbit Un-conjugated IHC, IHC (p), WB Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE) Anti-SUZ12 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml. This image was taken for the unconjugated form of this product. Other f ... 50 μg Log in to see 11 to 14 Days
$727.83
Details
Human Rabbit Un-conjugated ChIPSeq, ChIP, WB Suz12 antibody (pAb) tested by ChIP-Seq. ChIP was performed using the ChIP-IT® High Sensitivity Kit (Cat. No. 53040) with 30 ug of chromatin from a human B cell lymphoma cell line and 10 µl of antibody. ChIP DNA was sequenced on the Illumina HiSeq and 15 million sequence tags were mapped to identify Suz12 binding sites. The image shows binding across a region of chromosome 12. Suz12 antibody (pAb) tested by ChIP. Chromatin immunoprecipitation (ChIP) was performed using the ChIP-IT® High Sensitivity Kit (Cat. No. 53040) with 30 µg of chromatin from human non-small cell lung carcinoma cell line NCI-H1299 cells and 10 µl of Suz12 antibody. ChIP DNA was used in qPCR with the control primer pairs or gene-specific primer pairs as indicated. Data are presented as Binding Events Detected per 1000 Cells using Active Motif's Epigenetic Services normalization scheme which accounts for primer efficiency and the amount of chromatin used in the ChIP reaction. 100 μL Log in to see 1 to 2 Days
$507.50
Details
Human Mouse Un-conjugated ELISA, WB Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng) Western blot analysis using SUZ12 mAb against human SUZ12 (AA: 1-139) recombinant protein. (Expected MW is 39.9 kDa) 0.1 mg Log in to see 8 to 11 Days
$577.50
Details
Human Rabbit Un-conjugated ChIP, WB 25 μg Log in to see 2 to 3 Days
$245.00
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 11 to 14 Days
$551.83
Details
Human Mouse Un-conjugated ELISA, IHC, WB Figure 1: Western blot analysis using SUZ12 mAb against HEK293 (1) and SUZ12(AA: 533-739)-hIgGFc transfected HEK293 (2) cell lysate. Dilution: 1/500 - 1/2000 Figure 2: Immunohistochemical analysis of paraffin-embedded kidney convoluted tubule tissues (left) and esophageal cancer tissues (right) using SUZ12 mouse mAb with DAB staining. Dilution: 1/200 - 1/1000 100 μL Log in to see 8 to 11 Days
$491.79
Details

Top referenced anti-SUZ12 Polycomb Repressive Complex 2 Subunit Antibodies

  1. Human Polyclonal SUZ12 Primary Antibody for ChIPSeq, ChIP - ABIN4889655 : Rossetto, Tarrant-Elorza, Pari: Cis and trans acting factors involved in human cytomegalovirus experimental and natural latent infection of CD14 (+) monocytes and CD34 (+) cells. in PLoS pathogens 2013 (PubMed)
    Show all 4 Pubmed References

  2. Human Monoclonal SUZ12 Primary Antibody for ICC, ELISA - ABIN969427 : Li, Ma, Wang, Koontz, Nucci, Sklar: Effects of rearrangement and allelic exclusion of JJAZ1/SUZ12 on cell proliferation and survival. in Proceedings of the National Academy of Sciences of the United States of America 2007 (PubMed)
    Show all 2 Pubmed References

  3. Human Monoclonal SUZ12 Primary Antibody for ChIP, IP - ABIN2668948 : Pasini, Hansen, Christensen, Agger, Cloos, Helin: Coordinated regulation of transcriptional repression by the RBP2 H3K4 demethylase and Polycomb-Repressive Complex 2. in Genes & development 2008 (PubMed)
    Show all 2 Pubmed References

  4. Cow (Bovine) Polyclonal SUZ12 Primary Antibody for WB - ABIN2780973 : De Cegli, Iacobacci, Flore, Gambardella, Mao, Cutillo, Lauria, Klose, Illingworth, Banfi, di Bernardo: Reverse engineering a mouse embryonic stem cell-specific transcriptional network reveals a new modulator of neuronal differentiation. in Nucleic acids research 2013 (PubMed)
    Show all 2 Pubmed References

  5. Human Monoclonal SUZ12 Primary Antibody for IHC, ELISA - ABIN969426 : Hansen, Bracken, Pasini, Dietrich, Gehani, Monrad, Rappsilber, Lerdrup, Helin: A model for transmission of the H3K27me3 epigenetic mark. in Nature cell biology 2008 (PubMed)

More Antibodies against SUZ12 Polycomb Repressive Complex 2 Subunit Interaction Partners

Mouse (Murine) SUZ12 Polycomb Repressive Complex 2 Subunit (SUZ12) interaction partners

  1. we found that the miRNA biogenesis enzyme DICER was required for the binding of the PRC2 core components EZH2 and SUZ12, and for the presence of the PRC2-mediated histone modification H3K27me3 at many bivalent genes

  2. Biochemical as well as functional experiments revealed that Spt6 could compete for binding of the PRC2 methyltransferase Ezh2 to Suz12 and reduce PRC2 chromatin engagement.

  3. lncRNA OL1 interacts with Suz12-PRC2 complex to orchestrate the oligodendrocyte differentiation program.

  4. in the skin epithelium, EED, Suz12, and Ezh1/2 function largely as subunits of the PRC2 complex and have roles in skin development

  5. Although Suz12 was required for lymphoid development, deletion in individual blood cell lineages revealed that it was dispensable for the development of granulocytic, monocytic, and megakaryocytic cells.

  6. Suz12-dependent recruitment of Tet1 contributes to epigenetic plasticity throughout cell differentiation.

  7. PRC2 is a tumor suppressor in Emicro-myc lymphomagenesis, because disease onset was accelerated by heterozygosity for Suz12 or by short hairpin RNA-mediated knockdown of Suz12 or Ezh2.

  8. PRC2 supports aberrant self-renewal in a mouse model of MLL-AF9;Nras(G12D) acute myeloid leukemia.

  9. The distinct expression profile of the identified Suz12 repressed genes in combination with the proliferation genes hold promise as biomarkers for progression of chronic Hepatitis B V infection to Hepatocellular Carcinoma.

  10. polycomb proteins BMI1 and SUZ12 are required for cell transformation induced by organic arsenic exposure

  11. Data indicate that binding of EZH2, SUZ12 and EED, the 3 subunits of Plybomb repressive complex 2 (PRC2), is required for PRC2 full activity, and late during viral infection, a significant increase in PRC2 protein association with chromatin.

  12. identify polycomb-like 2 and Polycomb Repressive Complex 2 transcriptional targets and draft regulatory networks.[Polycomb Repressive Complex 2 and polycomb-like 2]

  13. Data show that RARgamma is required for deposition of H2A.Z and Suz12 at RA target genes, and that in embryonic stem cells both RARgamma and Suz12 exist in a multi-protein complex in the absence of ligand.

  14. Quantitative mass spectrometry was used to investigate the effects of Suz12 deficiency on H3.2 and H3.3 from mouse embryonic stem cells.

  15. Here we show that mice lacking Suz12, like Ezh2 and Eed mutant mice, are not viable and die during early postimplantation stages displaying severe developmental and proliferative defects.

  16. Data show that Suz12(-/-) mouse embryonic stem cells can be established and expanded in tissue culture, but are impaired in proper differentiation, resulting in a lack of repression of cell markers as well as activation of differentiation-specific genes.

  17. SUZ12 regulates H3-K9 methylation in an EZH2-independent fashion. Suz12 is required for histone H3 lysine 9 tri-methylation (H3K9me3) in differentiated but not undifferentiated mouse embryonic stem cells.

  18. transcriptional components of the RAR signaling pathway are specifically required for displacement of SUZ12 from RAREs during RA-mediated differentiation of F9 cells

  19. Suz12, a component of the polycomb repressor complex 2, is recruited to the beta-globin gene.

  20. loss of Suz12 function enhances hematopoietic stem cell (HSC) activity

Human SUZ12 Polycomb Repressive Complex 2 Subunit (SUZ12) interaction partners

  1. Functional assays to reveal the targets of n-miR-G665 showed that polycomb protein Suz12 is regulated by n-miR-G665, which in turn regulates the expression of n-miR-G665 through feedback loop mechanism.

  2. Data suggest the polycomb repressive complex 2 subunits EZH2, SUZ12, and EED protein axis as promising therapeutic target for treating sarcoma.

  3. High SUZ12 expression is associated with invasion and metastasis of tumor budding cells in tongue squamous cell carcinoma.

  4. we analyzed eight probands with clinically suspected Weaver syndrome by whole-exome sequencing and identified three mutations: a 25.4-kb deletion partially involving EZH2 and CUL1 ,a missense mutation , and a missense mutation in SUZ12 inherited from her father .In vitro functional analyses demonstrated that the identified EED and SUZ12 missense mutations cause decreased decreased trimethylation of lysine 27 of H3

  5. PRE-PIK3C2B interacts directly with YY1 in vitro and recruits PRC2 complex in vivo. The localization of PcG proteins including YY1 to PRE-PIK3C2B in HEK cells is decreased on knock-down of either YY1 or SUZ12.

  6. EZH1, SUZ12 and UXT work synergistically to regulate pathway activation in the nucleus.

  7. Mutation in the SUZ12 gene is associated with malignant peripheral nerve sheath tumors.

  8. Overexpression of miR-105 inhibited cell proliferation, tumorigenesis, migration, invasion, and drug sensitivity, whereas overexpression of suppressor of Zeste 12 homolog antagonized the tumor-suppressive functions of miR-105.

  9. Mutations of SUZ12 and EED are reported to have tumor suppressive functions. (Review)

  10. The difference in the SUZ12 and CBX8 genes expression were significantly divergent between tumors and their marginal tissues.

  11. Activation of EZH2 and SUZ12 Regulated by E2F1 Predicts the Disease Progression and Aggressive Characteristics of Bladder Cancer

  12. Data show that RAS protein activation was the initiating oncogenic event, with polycomb repressive complex 2 (PRC2) subunits impairment being a secondary event.

  13. SUZ12 is a key molecule in the regulation of monoallelic expression of IGF2.

  14. Overexpression of Suz12 was associated with lung adenocarcinoma.

  15. found that expression of PcG proteins and H3K27me3 showed prognostic value in our study cohort

  16. this study described that miR-489 expression level was significantly reduced in lung cancer samples (n = 115) and cell lines. Abnormal expression of miR-489 regulated the cells invasion by binding SUZ12 3'-UTR in vitro.

  17. Upregulation of SUZ12 was found to play a key role in gastric cancer cell proliferation and metastasis through the regulation of EMT and KLF2 expression

  18. downregulation of SUZ12 and ZNF198 leads to epigenetic reprogramming of infected hepatocytes. Because both Plk1 and HOTAIR are elevated in many human cancers, we propose that their combined effects are involved in epigenetic reprogramming

  19. Conclude that the expression of SUZ12 is increased along with the degree of infiltration and metastasis of gastric carcinoma.

  20. Data show that overall enhancer of zeste 2 (EZH2), embryonic ectoderm development (EED) and suppressor of zeste 12 homolog (SUZ12) expression in the colorectal cancer (CRC) tissues was significantly increased than in the non-cancerous tissue.

SUZ12 Polycomb Repressive Complex 2 Subunit (SUZ12) Antigen Profile

Protein Summary

This zinc finger gene has been identified at the breakpoints of a recurrent chromosomal translocation reported in endometrial stromal sarcoma. Recombination of these breakpoints results in the fusion of this gene and JAZF1. The protein encoded by this gene contains a zinc finger domain in the C terminus of the coding region.

Gene names and symbols associated with SUZ12

  • SUZ12 polycomb repressive complex 2b subunit (suz12b) antibody
  • SUZ12 polycomb repressive complex 2 subunit (Suz12) antibody
  • suppressor of zeste 12 homolog (Drosophila) (Suz12) antibody
  • SUZ12 polycomb repressive complex 2 subunit (SUZ12) antibody
  • SUZ12 polycomb repressive complex 2 subunit S homeolog (suz12.S) antibody
  • 2610028O16Rik antibody
  • AI195385 antibody
  • AU016842 antibody
  • AW536442 antibody
  • CHET9 antibody
  • ChET 9 protein antibody
  • D11Ertd530e antibody
  • fc31h10 antibody
  • im:7153578 antibody
  • JJAZ1 antibody
  • mKIAA0160 antibody
  • si:dkey-10p5.2 antibody
  • suz12 antibody
  • wu:fc31h10 antibody
  • Xsuz12 antibody

Protein level used designations for SUZ12

Suppressor of zeste 12 protein homolog B , polycomb protein suz12-B , polycomb protein SUZ12 , Suppressor of zeste 12 protein homolog , polycomb protein Suz12 , suppressor of zeste 12 protein homolog , suppressor of zeste 12 homolog , SUZ12 polycomb repressive complex 2 subunit S homeolog , Chromatin precipitated E2F target 9 protein , Joined to JAZF1 protein , chET 9 protein , chromatin precipitated E2F target 9 protein , joined to JAZF1 protein

GENE ID SPECIES
561871 Danio rerio
688041 Rattus norvegicus
100720614 Cavia porcellus
52615 Mus musculus
491158 Canis lupus familiaris
100294712 Sus scrofa
100174799 Xenopus laevis
23512 Homo sapiens
538774 Bos taurus
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