anti-SUZ12 Polycomb Repressive Complex 2 Subunit (SUZ12) Antibodies

SUZ12 encodes a core component of the polycomb repressive complex 2 (PRC2) that also includes, at least, embryonic ectoderm development protein (EED) and enhancer of zeste homolog 1 or 2 (EZH1 or EZH2). Additionally we are shipping SUZ12 Polycomb Repressive Complex 2 Subunit Kits (6) and SUZ12 Polycomb Repressive Complex 2 Subunit Proteins (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SUZ12 688041  
SUZ12 52615 Q80U70
SUZ12    
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Top anti-SUZ12 Polycomb Repressive Complex 2 Subunit Antibodies at antibodies-online.com

Showing 10 out of 89 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated ChIPSeq, ChIP, WB Suz12 antibody (pAb) tested by ChIP-Seq. ChIP was performed using the ChIP-IT® High Sensitivity Kit (Cat. No. 53040) with 30 ug of chromatin from a human B cell lymphoma cell line and 10 µl of antibody. ChIP DNA was sequenced on the Illumina HiSeq and 15 million sequence tags were mapped to identify Suz12 binding sites. The image shows binding across a region of chromosome 12. Suz12 antibody (pAb) tested by ChIP. Chromatin immunoprecipitation (ChIP) was performed using the ChIP-IT® High Sensitivity Kit (Cat. No. 53040) with 30 µg of chromatin from human non-small cell lung carcinoma cell line NCI-H1299 cells and 10 µl of Suz12 antibody. ChIP DNA was used in qPCR with the control primer pairs or gene-specific primer pairs as indicated. Data are presented as Binding Events Detected per 1000 Cells using Active Motif's Epigenetic Services normalization scheme which accounts for primer efficiency and the amount of chromatin used in the ChIP reaction. 100 μL Log in to see 1 to 2 Days
$507.50
Details
Cow Rabbit Un-conjugated WB <b>WB Suggested Anti-SUZ12 Antibody Titration: </b>0.2-1 ug/ml<br><b>ELISA Titer: </b>1:312500<br><b>Positive Control: </b>721_B cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated ChIP, IHC, WB Chromatin Immunoprecipitation (ChIP) Using SUZ12 Antibody - middle region (ARP32515_P050) and HCT116 Cells 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Mouse Un-conjugated ChIP, IP, IHC Suz12 antibody (mAb) tested by ChIP. Chromatin IP performed using the ChIP-IT® Express Kit (Catalog No. 53008) and HeLa chromatin (1.5 x 106 cell equivalents per ChIP) using 10 µg of Suz12 antibody or the equivalent amount of rabbit IgG as a negative control. Real time, quantitative PCR (RT-qPCR) was performed on DNA purified from each of the ChIP reactions using a primer pair specific for the Myt1 gene promoter. Data are presented as Fold Enrichment of the ChIP antibody signal versus the negative control IgG using the ddCT method. 100 μg Log in to see 1 to 2 Days
$495.83
Details
Human Rabbit Un-conjugated ChIP, WB 25 μg Log in to see 2 to 3 Days
$245.00
Details
Bat Rabbit Un-conjugated IHC (p), WB Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Log in to see 7 to 9 Days
$727.83
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 7 to 9 Days
$551.83
Details
Human Mouse Un-conjugated ICC, ELISA, WB Figure 1: Immunofluorescence analysis of U251 cells using SUZ12 mouse mAb (green) . Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin. Figure 2: Immunofluorescence analysis of MCF-7 cells using SUZ12 mouse mAb (green) . Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin. 100 μL Log in to see 2 to 3 Days
$393.80
Details
Human Mouse Un-conjugated IHC (p), ELISA, WB Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μL Log in to see 7 to 9 Days
$484.00
Details
Human Mouse Un-conjugated ELISA, ICC, IF, WB 100 μL Log in to see 7 to 9 Days
$522.50
Details

SUZ12 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality
Rat (Rattus)


Mouse (Murine)


Human , ,
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Top referenced anti-SUZ12 Polycomb Repressive Complex 2 Subunit Antibodies

  1. Human Polyclonal SUZ12 Primary Antibody for ChIPSeq, ChIP - ABIN4889655 : Rossetto, Tarrant-Elorza, Pari: Cis and trans acting factors involved in human cytomegalovirus experimental and natural latent infection of CD14 (+) monocytes and CD34 (+) cells. in PLoS pathogens 2013 (PubMed)
    Show all 4 Pubmed References

  2. Human Monoclonal SUZ12 Primary Antibody for ICC, ELISA - ABIN969427 : Li, Ma, Wang, Koontz, Nucci, Sklar: Effects of rearrangement and allelic exclusion of JJAZ1/SUZ12 on cell proliferation and survival. in Proceedings of the National Academy of Sciences of the United States of America 2007 (PubMed)
    Show all 2 Pubmed References

  3. Human Monoclonal SUZ12 Primary Antibody for ChIP, IP - ABIN2668948 : Pasini, Hansen, Christensen, Agger, Cloos, Helin: Coordinated regulation of transcriptional repression by the RBP2 H3K4 demethylase and Polycomb-Repressive Complex 2. in Genes & development 2008 (PubMed)
    Show all 2 Pubmed References

  4. Human Monoclonal SUZ12 Primary Antibody for IHC, ELISA - ABIN969426 : Hansen, Bracken, Pasini, Dietrich, Gehani, Monrad, Rappsilber, Lerdrup, Helin: A model for transmission of the H3K27me3 epigenetic mark. in Nature cell biology 2008 (PubMed)

  5. Cow (Bovine) Polyclonal SUZ12 Primary Antibody for WB - ABIN2780973 : De Cegli, Iacobacci, Flore, Gambardella, Mao, Cutillo, Lauria, Klose, Illingworth, Banfi, di Bernardo: Reverse engineering a mouse embryonic stem cell-specific transcriptional network reveals a new modulator of neuronal differentiation. in Nucleic acids research 2013 (PubMed)
    Show all 2 Pubmed References

More Antibodies against SUZ12 Polycomb Repressive Complex 2 Subunit Interaction Partners

Mouse (Murine) SUZ12 Polycomb Repressive Complex 2 Subunit (SUZ12) interaction partners

  1. we found that the miRNA biogenesis enzyme DICER was required for the binding of the PRC2 core components EZH2 and SUZ12, and for the presence of the PRC2-mediated histone modification H3K27me3 at many bivalent genes

  2. Biochemical as well as functional experiments revealed that Spt6 could compete for binding of the PRC2 methyltransferase Ezh2 to Suz12 and reduce PRC2 chromatin engagement.

  3. lncRNA OL1 interacts with Suz12-PRC2 complex to orchestrate the oligodendrocyte differentiation program.

  4. in the skin epithelium, EED (show EED Antibodies), Suz12, and Ezh1 (show EZH1 Antibodies)/2 function largely as subunits of the PRC2 complex and have roles in skin development

  5. Although Suz12 was required for lymphoid development, deletion in individual blood cell lineages revealed that it was dispensable for the development of granulocytic, monocytic, and megakaryocytic cells.

  6. Suz12-dependent recruitment of Tet1 (show TET1 Antibodies) contributes to epigenetic plasticity throughout cell differentiation.

  7. PRC2 is a tumor suppressor in Emicro-myc (show MYC Antibodies) lymphomagenesis, because disease onset was accelerated by heterozygosity for Suz12 or by short hairpin RNA-mediated knockdown of Suz12 or Ezh2 (show EZH2 Antibodies).

  8. PRC2 supports aberrant self-renewal in a mouse model of MLL (show MLL Antibodies)-AF9 (show MLLT3 Antibodies);Nras (show NRAS Antibodies)(G12D) acute myeloid leukemia (show BCL11A Antibodies).

  9. The distinct expression profile of the identified Suz12 repressed genes in combination with the proliferation genes hold promise as biomarkers for progression of chronic Hepatitis B V infection to Hepatocellular Carcinoma.

  10. polycomb proteins BMI1 and SUZ12 are required for cell transformation induced by organic arsenic exposure

SUZ12 Polycomb Repressive Complex 2 Subunit (SUZ12) Antigen Profile

Protein Summary

This gene encodes a core component of the polycomb repressive complex 2 (PRC2) that also includes, at least, embryonic ectoderm development protein (EED) and enhancer of zeste homolog 1 or 2 (EZH1 or EZH2). Through the methyltransferase activity of EZH1 or EZH2, the PRC2 complex methylates Lys9 and Lys27 of histone 3 and Lys26 of histone 1, leading to recruitment of the PRC1 complex, histone 2A ubiquitylation and transcriptional repression of the target genes. This gene product is essential for the activity and integrity of the PRC2 complex, and is required for X chromosome inactivation, stem cell maintenance and differentiation. Two transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with SUZ12

  • SUZ12 polycomb repressive complex 2 subunit (Suz12) antibody
  • suppressor of zeste 12 homolog (Drosophila) (Suz12) antibody
  • 2610028O16Rik antibody
  • AI195385 antibody
  • AU016842 antibody
  • AW536442 antibody
  • D11Ertd530e antibody
  • mKIAA0160 antibody

Protein level used designations for SUZ12

polycomb protein SUZ12 , Suppressor of zeste 12 protein homolog , polycomb protein Suz12 , suppressor of zeste 12 protein homolog

GENE ID SPECIES
688041 Rattus norvegicus
100720614 Cavia porcellus
52615 Mus musculus
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