Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
SUZ12 encodes a core component of the polycomb repressive complex 2 (PRC2) that also includes, at least, embryonic ectoderm development protein (EED) and enhancer of zeste homolog 1 or 2 (EZH1 or EZH2). Additionally we are shipping SUZ12 Polycomb Repressive Complex 2 Subunit Kits (6) and SUZ12 Polycomb Repressive Complex 2 Subunit Proteins (5) and many more products for this protein.
Showing 10 out of 104 products:
Human Polyclonal SUZ12 Primary Antibody for ChIPSeq, ChIP - ABIN4889655
Rossetto, Tarrant-Elorza, Pari: Cis and trans acting factors involved in human cytomegalovirus experimental and natural latent infection of CD14 (+) monocytes and CD34 (+) cells. in PLoS pathogens 2013
Show all 4 Pubmed References
Human Monoclonal SUZ12 Primary Antibody for ICC, ELISA - ABIN969427
Li, Ma, Wang, Koontz, Nucci, Sklar: Effects of rearrangement and allelic exclusion of JJAZ1/SUZ12 on cell proliferation and survival. in Proceedings of the National Academy of Sciences of the United States of America 2007
Show all 2 Pubmed References
Human Monoclonal SUZ12 Primary Antibody for ChIP, IP - ABIN2668948
Pasini, Hansen, Christensen, Agger, Cloos, Helin: Coordinated regulation of transcriptional repression by the RBP2 H3K4 demethylase and Polycomb-Repressive Complex 2. in Genes & development 2008
Show all 2 Pubmed References
Human Monoclonal SUZ12 Primary Antibody for IHC, ELISA - ABIN969426
Hansen, Bracken, Pasini, Dietrich, Gehani, Monrad, Rappsilber, Lerdrup, Helin: A model for transmission of the H3K27me3 epigenetic mark. in Nature cell biology 2008
Cow (Bovine) Polyclonal SUZ12 Primary Antibody for WB - ABIN2780973
De Cegli, Iacobacci, Flore, Gambardella, Mao, Cutillo, Lauria, Klose, Illingworth, Banfi, di Bernardo: Reverse engineering a mouse embryonic stem cell-specific transcriptional network reveals a new modulator of neuronal differentiation. in Nucleic acids research 2013
Show all 2 Pubmed References
we found that the miRNA biogenesis enzyme DICER was required for the binding of the PRC2 core components EZH2 and SUZ12, and for the presence of the PRC2-mediated histone modification H3K27me3 at many bivalent genes
Biochemical as well as functional experiments revealed that Spt6 could compete for binding of the PRC2 methyltransferase Ezh2 to Suz12 and reduce PRC2 chromatin engagement.
lncRNA OL1 interacts with Suz12-PRC2 complex to orchestrate the oligodendrocyte differentiation program.
in the skin epithelium, EED (show EED Antibodies), Suz12, and Ezh1 (show EZH1 Antibodies)/2 function largely as subunits of the PRC2 complex and have roles in skin development
Although Suz12 was required for lymphoid development, deletion in individual blood cell lineages revealed that it was dispensable for the development of granulocytic, monocytic, and megakaryocytic cells.
Suz12-dependent recruitment of Tet1 (show TET1 Antibodies) contributes to epigenetic plasticity throughout cell differentiation.
PRC2 is a tumor suppressor in Emicro-myc (show MYC Antibodies) lymphomagenesis, because disease onset was accelerated by heterozygosity for Suz12 or by short hairpin RNA-mediated knockdown of Suz12 or Ezh2 (show EZH2 Antibodies).
PRC2 supports aberrant self-renewal in a mouse model of MLL (show MLL Antibodies)-AF9 (show MLLT3 Antibodies);Nras (show NRAS Antibodies)(G12D) acute myeloid leukemia (show BCL11A Antibodies).
The distinct expression profile of the identified Suz12 repressed genes in combination with the proliferation genes hold promise as biomarkers for progression of chronic Hepatitis B V infection to Hepatocellular Carcinoma.
polycomb proteins BMI1 and SUZ12 are required for cell transformation induced by organic arsenic exposure
Data suggest the polycomb (show CBX2 Antibodies) repressive complex 2 subunits EZH2 (show EZH2 Antibodies), SUZ12, and EED (show EED Antibodies) protein axis as promising therapeutic target for treating sarcoma.
High SUZ12 expression is associated with invasion and metastasis of tumor budding cells in tongue squamous cell carcinoma.
we analyzed eight probands with clinically suspected Weaver syndrome by whole-exome sequencing and identified three mutations: a 25.4-kb deletion partially involving EZH2 and CUL1 ,a missense mutation , and a missense mutation in SUZ12 inherited from her father .In vitro functional analyses demonstrated that the identified EED and SUZ12 missense mutations cause decreased decreased trimethylation of lysine 27 of H3
PRE-PIK3C2B interacts directly with YY1 in vitro and recruits PRC2 complex in vivo. The localization of PcG proteins including YY1 to PRE-PIK3C2B in HEK cells is decreased on knock-down of either YY1 or SUZ12.
EZH1 (show EZH1 Antibodies), SUZ12 and UXT (show UXT Antibodies) work synergistically to regulate pathway activation in the nucleus.
Mutation in the SUZ12 gene is associated with malignant peripheral nerve sheath tumors.
Overexpression of miR (show MLXIP Antibodies)-105 inhibited cell proliferation, tumorigenesis, migration, invasion, and drug sensitivity, whereas overexpression of suppressor of Zeste 12 homolog antagonized the tumor-suppressive functions of miR (show MLXIP Antibodies)-105.
Mutations of SUZ12 and EED (show EED Antibodies) are reported to have tumor suppressive functions. (Review)
The difference in the SUZ12 and CBX8 (show CBX8 Antibodies) genes expression were significantly divergent between tumors and their marginal tissues.
Activation of EZH2 (show EZH2 Antibodies) and SUZ12 Regulated by E2F1 (show E2F1 Antibodies) Predicts the Disease Progression and Aggressive Characteristics of Bladder Cancer
This zinc finger gene has been identified at the breakpoints of a recurrent chromosomal translocation reported in endometrial stromal sarcoma. Recombination of these breakpoints results in the fusion of this gene and JAZF1. The protein encoded by this gene contains a zinc finger domain in the C terminus of the coding region.
Suppressor of zeste 12 protein homolog B
, polycomb protein suz12-B
, polycomb protein SUZ12
, Suppressor of zeste 12 protein homolog
, polycomb protein Suz12
, suppressor of zeste 12 protein homolog
, suppressor of zeste 12 homolog
, SUZ12 polycomb repressive complex 2 subunit S homeolog
, Chromatin precipitated E2F target 9 protein
, Joined to JAZF1 protein
, chET 9 protein
, chromatin precipitated E2F target 9 protein
, joined to JAZF1 protein