anti-SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A, Member 2 (SMARCA2) Antibodies

The protein encoded by SMARCA2 is a member of the SWI/SNF family of proteins and is highly similar to the brahma protein of Drosophila. Additionally we are shipping SMARCA2 Proteins (5) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SMARCA2 6595 P51531
SMARCA2 67155 Q6DIC0
SMARCA2 361745  
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Top anti-SMARCA2 Antibodies at antibodies-online.com

Showing 10 out of 48 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB Host: Rabbit Target Name: SMARCA2 Sample Type: Jurkat Whole Cell lysates Antibody Dilution: 1.0ug/ml 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p) Immunocytochemistry/Immunofluorescence: BRM Antibody [NBP1-90015] - Staining of human cell line U-2 OS shows positivity in nucleus but not nucleoli & vesicles. Immunohistochemistry-Paraffin: BRM Antibody [NBP1-90015] - Staining of human cerebral cortex shows strong nuclear positivity in neuronal cells. 0.1 mL Log in to see 10 to 13 Days
$491.63
Details
Cow Rabbit Un-conjugated IHC, WB WB Suggested Anti-SMARCA2 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:312500  Positive Control:  HepG2 cell lysate Human Skin 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated WB Western blot analysis of BRM expression in HepG2 (A), HeLa (B), THP1 (C), NIH3T3 (D) whole cell lysates. 200 μL Log in to see 13 to 14 Days
$487.50
Details
Human Rat Un-conjugated ChIP, ICC, IF, WB SMARCA2 / BRM antibody (mAb) tested by ChIP. Chromatin IP performed using the ChIP-IT® Express Kit (Catalog No. 53008) and HeLa Chromatin (1.5 x 106 cell equivalents per ChIP) using 10 µg of SMARCA2 / BRM antibody or the equivalent amount of rat IgG as a negative control. Real time, quantitative PCR (RT-qPCR) was performed on DNA purified from each of the ChIP reactions using a primer pair specific for the CD44 gene. Data are presented as Fold Enrichment of the ChIP antibody signal versus the negative control IgG using the ddCT method. SMARCA2 / BRM antibody (mAb) tested by Immunofluorescence. Formaldehyde fixed HeLa cells stained with SMARCA2 / BRM antibody at a 0.5 µg/ml dilution. 100 μg Log in to see 1 to 2 Days
$495.83
Details
Human Rabbit Un-conjugated ELISA, WB 100 μL Log in to see 16 Days
$181.73
Details
Bat Rabbit Un-conjugated IHC, IHC (p), WB 50 μg Log in to see 7 to 9 Days
$551.83
Details
Human Rabbit Un-conjugated IP, WB 0.1 mL Log in to see 7 to 9 Days
$556.31
Details
Human Rabbit Un-conjugated IP, WB 0.1 mL Log in to see 7 to 9 Days
$556.31
Details
Human Rabbit Un-conjugated IP, WB 0.1 mL Log in to see 7 to 9 Days
$556.31
Details

Top referenced anti-SMARCA2 Antibodies

  1. Human Polyclonal SMARCA2 Primary Antibody for ICC, IF - ABIN4285267 : Van Houdt, Nowakowska, Sousa, van Schaik, Seuntjens, Avonce, Sifrim, Abdul-Rahman, van den Boogaard, Bottani, Castori, Cormier-Daire, Deardorff, Filges, Fryer, Fryns, Gana, Garavelli et al.: Heterozygous missense mutations in SMARCA2 cause Nicolaides-Baraitser syndrome. ... in Nature genetics 2012 (PubMed)
    Show all 2 Pubmed References

  2. Human Monoclonal SMARCA2 Primary Antibody for ChIP, ICC - ABIN2668505 : Okada, Harada, Saiwai, Nakamura, Ohkawa: Generation of a rat monoclonal antibody specific for Brm. in Hybridoma (2005) 2009 (PubMed)

More Antibodies against SMARCA2 Interaction Partners

Human SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A, Member 2 (SMARCA2) interaction partners

  1. Here, the authors show that C-terminally truncated forms of both SMARCA2 and SMARCA4 (show SMARCA4 Antibodies), produced by caspase (show CASP3 Antibodies)-mediated cleavage, accumulate in cells infected with different RNA or DNA viruses. The levels of truncated SMARCA2 or SMARCA4 (show SMARCA4 Antibodies) strongly correlate with the degree of cell damage and death observed after virus infection.

  2. at genes where BRG1 (show SMARCA4 Antibodies) and BRM antagonize one another we observe a nearly complete rescue of gene expression changes in the combined BRG/BRM double knockdown

  3. Expression of BRM and MMP2 (show MMP2 Antibodies) in the thoracic aortic aneurysm and aortic dissection is very high, indicating that BRM and MMP2 (show MMP2 Antibodies) may play important roles in the occurrence and development of thoracic aortic aneurysm and aortic dissection.

  4. Although Genome-Wide Association studies have not been carried out in the field of alcohol-related hepatocellular carcinoma (HCC (show FAM126A Antibodies)), common single nucleotide polymorphisms conferring a small increase in the risk of liver cancer risk have been identified. Specific patterns of gene mutations including CTNNB1 (show CTNNB1 Antibodies), TERT (show TERT Antibodies), ARID1A (show ARID1A Antibodies) and SMARCA2 exist in alcohol-related HCC (show FAM126A Antibodies). [review]

  5. PRC2-mediated repression of SMARCA2 predicts EZH2 (show EZH2 Antibodies) inhibitor activity in SWI (show SMARCA1 Antibodies)/SNF (show SNRPA Antibodies) mutant tumors.

  6. two promoter BRM germline variants were associated with worse outcome in our esophageal adenocarcinoma (EAC (show CYLD Antibodies)) patients. This significantly poorer outcome was independent of TNM (show ODZ1 Antibodies) classification at diagnosis or other clinic-demographic variables.

  7. Epigenetic regulatory molecules bind to two BRM promoter sequence variants but not to their wild-type sequences. These variants are associated with adverse overall and progression-free survival. Decreased BRM gene expression, seen with these variants, is also associated with worse overall survival

  8. We also demonstrate that tazemetostat, a potent and selective EZH2 (show EZH2 Antibodies) inhibitor currently in phase II clinical trials, induces potent antiproliferative and antitumor effects in SCCOHT cell lines and xenografts deficient in both SMARCA2 and SMARCA4 (show SMARCA4 Antibodies). These results exemplify an additional class of rhabdoid-like tumors that are dependent on EZH2 (show EZH2 Antibodies) activity for survival.

  9. Two BRM promoter polymorphisms were strongly associated with hepatocellular carcinoma (HCC (show FAM126A Antibodies)) prognosis but were not associated with increased HCC (show FAM126A Antibodies) susceptibility.

  10. This de novo SMARCA2 missense mutation c.3721C>G, p.Gln1241Glu is the only reported mutation on exon 26 outside the ATPase (show DNAH8 Antibodies) domain of SMARCA2 to be associated with Nicolaides-Baraitser syndrome and adds to chromatin remodeling as a pathway for epileptogenesis.

Mouse (Murine) SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A, Member 2 (SMARCA2) interaction partners

  1. PRC2-mediated repression of SMARCA2 predicts EZH2 (show EZH2 Antibodies) inhibitor activity in SWI (show SMARCA1 Antibodies)/SNF (show SNRPA Antibodies) mutant tumors.

  2. BRG1 (show SMARCA4 Antibodies)/BRM and c-MYC (show MYC Antibodies) have an antagonistic relationship regulating the expression of cardiac conduction genes that maintain contractility, which is reminiscent of their antagonistic roles as a tumor suppressor and oncogene (show RAB1A Antibodies) in cancer.

  3. SWI (show SMARCA1 Antibodies)/SNF (show SNRPA Antibodies) chromatin remodeler subunits Brg1 (show SMARCA4 Antibodies) and Brm are expressed differentially during drug-induced liver injury and regeneration in a mouse model.

  4. these findings described a role for BRG1 (show SMARCA4 Antibodies) and BRM in mitochondrial quality control, by regulating mitochondrial number, mitophagy, and mitochondrial dynamics not previously recognized in the adult cardiomyocyte

  5. BRM depletion enhances the proportion of cells expressing markers of osteoblast precursors at the expense of cells able to differentiate along the adipocyte lineage.

  6. Data show that knockdown of component of chromatin remodeling complex Brm or Baf170 (show SMARCC2 Antibodies) at different stages promotes reprogramming.

  7. Data reveal stage-specific roles of Brm during skeletal myogenesis, via formation of repressive and activatory SWI (show SMARCA1 Antibodies)/SNF (show SNRPA Antibodies) complexes.

  8. Brm protects from UV-induced hyperplastic growth in both cutaneous and corneal keratinocytes

  9. Data suggest that Brg1 (show SMARCA4 Antibodies) and Brm integrate various proinflammatory cues into cell adhesion molecule (show MCAM Antibodies) transactivation in endothelial injury.

  10. A SMARCA2-containing residual SWI (show SMARCA1 Antibodies)/SNF (show SNRPA Antibodies) complex underlies the oncogenic activity of SMARCA4 (show SMARCA4 Antibodies) mutant cancers.

SMARCA2 Antigen Profile

Protein Summary

The protein encoded by this gene is a member of the SWI/SNF family of proteins and is highly similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. Two transcript variants encoding different isoforms have been found for this gene, which contains a trinucleotide repeat (CAG) length polymorphism.

Gene names and symbols associated with SMARCA2

  • SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 (SMARCA2) antibody
  • SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 L homeolog (smarca2.L) antibody
  • SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 (Smarca2) antibody
  • SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 (smarca2) antibody
  • 2610209L14Rik antibody
  • BAF190 antibody
  • Brahma antibody
  • brm antibody
  • hBRM antibody
  • hSNF2a antibody
  • NCBRS antibody
  • psa-4 antibody
  • SNF2 antibody
  • SNF2alpha antibody
  • Snf2l2 antibody
  • SNF2LA antibody
  • Sth1p antibody
  • SWI2 antibody
  • wu:fa56c07 antibody
  • wu:fi27f11 antibody
  • zgc:66238 antibody

Protein level used designations for SMARCA2

ATP-dependent helicase SMARCA2 , BAF190B , BRG1-associated factor 190B , SNF2-alpha , SNF2/SWI2-like protein 2 , SWI/SNF-related matrix-associated actin-dependent regulator of chromatin a2 , global transcription activator homologous sequence , probable global transcription activator SNF2L2 , protein brahma homolog , sucrose nonfermenting 2-like protein 2 , SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 , subunit of the SWI/SNF chromatin remodeling complex , phasmid Socket Absent PSA-4

GENE ID SPECIES
6595 Homo sapiens
403380 Xenopus laevis
396040 Gallus gallus
67155 Mus musculus
334032 Danio rerio
476335 Canis lupus familiaris
540904 Bos taurus
361745 Rattus norvegicus
100126853 Sus scrofa
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