anti-Tumor Necrosis Factor Receptor Superfamily, Member 18 (TNFRSF18) Antibodies

TNFRSF18 encodes a member of the TNF-receptor superfamily. Additionally we are shipping TNFRSF18 Proteins (41) and TNFRSF18 Kits (23) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
TNFRSF18 21936 O35714
TNFRSF18 8784 Q9Y5U5
TNFRSF18 500598  
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Top anti-TNFRSF18 Antibodies at antibodies-online.com

Showing 10 out of 305 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB WB Suggested Anti-TNFRSF18 Antibody   Titration: 1 ug/ml   Positive Control: Hela Whole Cell Host:  Rabbit  Target Name:  TNFRSF18  Sample Tissue:  Human HCT116  Antibody Dilution:  1.0ug/ml 100 μL Log in to see 2 to 3 Days
$229.00
Details
Human Rabbit Un-conjugated IHC, WB WB Suggested Anti-TNFRSF18 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:312500  Positive Control:  Hela cell lysate Human Brain 100 μL Log in to see 2 to 3 Days
$319.00
Details
Human Mouse PE FACS Detection of GITR/TNFRSF18 in Human PBMCs by Flow Cytometry. Human peripheral blood mononuclear cells (PBMCs) treated with 1 ug/mL PHA for 24 hours were stained with Mouse Anti-Human GITR/TNFRSF18 PE-conjugated Mono-clonal Antibody. 100 Tests Log in to see 8 to 9 Days
$352.56
Details
Mouse Rabbit Un-conjugated WB Western blot analysis of TNFRSF18 using anti-TNFRSF18 antibody .  Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours. The sample well of each  Lane was loaded with 50ug of sample under reducing conditions.   Lane 1: rat kidney tissue lysate, Lane 2: mouse kidney tissue lysate.  After Electrophoresis, proteins were transferred to a Nitrocellulose membrane at 150mA for 50-90 minutes. Blocked the membrane with 5% Non-fat Milk/ TBS for 1.5 hour at RT. The membrane was incubated with rabbit anti-TNFRSF18 antigen affinity purified polyclonal antibody (Catalog # ) at 0.5 µg/mL overnight at 4°C, then washed with TBS-0.1%Tween 3 times with 5 minutes each and probed with a goat anti-rabbit IgG-HRP secondary antibody at a dilution of 1:10000 for 1.5 hour at RT. The signal is developed using an Enhanced Chemiluminescent detection (ECL) kit (Catalog # EK1002) with Tanon 5200 system. A specific band was detected for TNFRSF18 at approximately 28KD. The expected band size for TNFRSF18 is at 26KD. 100 μg Log in to see 4 to 6 Days
$240.00
Details
Human Rabbit Un-conjugated IF (p), IHC (p) Formalin-fixed and paraffin embedded human oral squamous cell carcinoma labeled with Anti-TNFRSF18 Polyclonal Antibody (ABIN738741), Unconjugated at 1:200, followed by conjugation to the secondary antibody and DAB staining Antigen: 0.2 µg/100 µL  Primary: Antiserum, 1:500, 1:1000, 1:2000, 1:4000, 1:8000, 1:16000, 1:32000;  Secondary: HRP conjugated Goat-Anti-Rabbit IgG at 1: 5000; TMB staining; Read the data in MicroplateReader by 450 100 μL Log in to see 3 to 7 Days
$317.90
Details
Human Mouse Fluorescein FACS Detection of GITR/TNFRSF18 in Human PBMCs by Flow Cytometry. Human peripheral blood mononuclear cells (PBMCs) treated with 1 ug/mL PHA for 24 hours were stained with Mouse Anti-Human GITR/TNFRSF18 Fluorescein-conjugated Monoclonal Antibody. 100 Tests Log in to see 8 to 9 Days
$287.02
Details
Human Mouse APC FACS Detection of GITR/TNFRSF18 in Human Blood CD4+ Lymphocytes by Flow Cytometry. Human peripheral blood CD4+ lymphocytes treated with PHA for 5 days were stained with Mouse Anti-Human GITR/TNFRSF18 APC-conjugated Monoclonal Antibody. 100 Tests Log in to see 8 to 9 Days
$406.80
Details
Human Goat Un-conjugated BR, CyTOF, FACS, IHC, WB GITR/TNFRSF18 in Human Tonsil. GITR/TNFRSF18 was detected in immersion fixed paraffin-embedded sections of human tonsil using Goat Anti-Human GITR/TNFRSF18 Antigen Affinity-purified Polyclonal Antibody  at 10 ug/mL overnight at 4 ᄚC. Tissue was stained using the Anti-Goat HRP-DAB Cell & 100 μg Log in to see 8 to 9 Days
$435.05
Details
Human Mouse Alexa Fluor 700 FACS Detection of GITR/TNFRSF18 in Human PBMCs by Flow Cytometry. Human peripheral blood mononuclear cells (PBMCs) treated with 5 ug/mL PHA for 5 days were stained with Mouse Anti-Human CD4 PE-conjugated Monoclonal Antibody. 100 Tests Log in to see 8 to 9 Days
$374.03
Details
Human Mouse Alexa Fluor 488 FACS Detection of GITR/TNFRSF18 in Human PBMCs by Flow Cytometry. Human peripheral blood mononuclear cells (PBMCs) treated with 1 ug/mL PHA for 24 hours were stained with Mouse Anti-Human GITR/TNFRSF18 Alexa Fluor 488-conjugated Monoclonal Antibody. 100 Tests Log in to see 8 to 9 Days
$374.03
Details

Top referenced anti-TNFRSF18 Antibodies

  1. Human Monoclonal TNFRSF18 Primary Antibody for FACS - ABIN4896951 : Godfrey, Spoden, Ge, Baker, Liu, Levine, June, Blazar, Porter: Cord blood CD4(+)CD25(+)-derived T regulatory cell lines express FoxP3 protein and manifest potent suppressor function. in Blood 2005 (PubMed)
    Show all 7 Pubmed References

  2. Mouse (Murine) Monoclonal TNFRSF18 Primary Antibody for BR, FACS - ABIN1176970 : Nocentini, Giunchi, Ronchetti, Krausz, Bartoli, Moraca, Migliorati, Riccardi: A new member of the tumor necrosis factor/nerve growth factor receptor family inhibits T cell receptor-induced apoptosis. in Proceedings of the National Academy of Sciences of the United States of America 1997 (PubMed)
    Show all 5 Pubmed References

  3. Mouse (Murine) Monoclonal TNFRSF18 Primary Antibody for CyTOF, FACS - ABIN4898962 : Dobrzynski, Fitzgerald, Cao, Mingozzi, Wang, Herzog: Prevention of cytotoxic T lymphocyte responses to factor IX-expressing hepatocytes by gene transfer-induced regulatory T cells. in Proceedings of the National Academy of Sciences of the United States of America 2006 (PubMed)
    Show all 4 Pubmed References

  4. Human Monoclonal TNFRSF18 Primary Antibody for FACS - ABIN4896943 : Tuyaerts, Van Meirvenne, Bonehill, Heirman, Corthals, Waldmann, Breckpot, Thielemans, Aerts: Expression of human GITRL on myeloid dendritic cells enhances their immunostimulatory function but does not abrogate the suppressive effect of CD4+CD25+ regulatory T cells. in Journal of leukocyte biology 2007 (PubMed)
    Show all 3 Pubmed References

  5. Human Monoclonal TNFRSF18 Primary Antibody for FACS - ABIN4896945 : Mandapathil, Hilldorfer, Szczepanski, Czystowska, Szajnik, Ren, Lang, Jackson, Gorelik, Whiteside: Generation and accumulation of immunosuppressive adenosine by human CD4+CD25highFOXP3+ regulatory T cells. in The Journal of biological chemistry 2010 (PubMed)
    Show all 3 Pubmed References

  6. Human Monoclonal TNFRSF18 Primary Antibody for FACS, ELISA - ABIN610275 : Ohmstede, Bland, Merrill, Sahyoun: Relationship of genes encoding Ca2+/calmodulin-dependent protein kinase Gr and calspermin: a gene within a gene. in Proceedings of the National Academy of Sciences of the United States of America 1991 (PubMed)
    Show all 2 Pubmed References

  7. Human Monoclonal TNFRSF18 Primary Antibody for FACS, ELISA - ABIN610418 : Brouet, Sonveaux, Dessy, Balligand, Feron: Hsp90 ensures the transition from the early Ca2+-dependent to the late phosphorylation-dependent activation of the endothelial nitric-oxide synthase in vascular endothelial growth factor-exposed endothelial cells. in The Journal of biological chemistry 2001 (PubMed)

  8. Human Monoclonal TNFRSF18 Primary Antibody for FACS, ELISA - ABIN610272 : Derkinderen, Toutant, Kadaré, Ledent, Parmentier, Girault: Dual role of Fyn in the regulation of FAK+6,7 by cannabinoids in hippocampus. in The Journal of biological chemistry 2001 (PubMed)

  9. Human Monoclonal TNFRSF18 Primary Antibody for FACS, ELISA - ABIN610417 : Fallon, Moreau, Croft, Labib, Gu, Fon: Parkin and CASK/LIN-2 associate via a PDZ-mediated interaction and are co-localized in lipid rafts and postsynaptic densities in brain. in The Journal of biological chemistry 2002 (PubMed)

More Antibodies against TNFRSF18 Interaction Partners

Mouse (Murine) Tumor Necrosis Factor Receptor Superfamily, Member 18 (TNFRSF18) interaction partners

  1. These results suggest that therapeutically targeting GITR represents a unique approach to cancer immunotherapy and suggests that a multimeric fusion protein may provide increased agonistic potential versus an antibody

  2. These findings support further study into combination partners for GITRL-FP that may augment CD8 T-cell priming as well as provide hypotheses that can be tested in human clinical trials exploring GITR agonists including GITRL-FP.

  3. Expression of human GITR was comparable with that of mouse GITR in tumor-infiltrating Tregs despite being drastically lower in other human TILs and in many human peripheral blood populations.

  4. anti-GITR mAb shifts Treg populations to enable immune attack on tumors, with clinical implications for molecular markers to modify emerging treatments.

  5. Continuous GITR stimulation through B cell Gitrl acts protective in a mouse model of atherosclerosis by regulating the balance between regulatory and effector memory CD4(+) T cells.

  6. these results indicate that blockade of GITR signaling can ameliorate arthritis progression mainly by modulating the follicular helper T cell response

  7. GITR appears as a potential target for intervention during infection by the parasite Toxoplasma gondii, even though further studies are still necessary to better characterize the immune response triggered by GITR activation during T. gondii infection

  8. our data suggest a critical role for GITR in Treg cell homeostasis and indicate that Ptpn22 independently affects the differentiation status of Treg cells and their homeostatic behavior

  9. These findings provide further support for the continued development of agonist anti-GITR antibodies as an immunotherapeutic strategy for osteosarcoma. We suggest that our proposed immunotherapy could be developed further to improve osteosarcoma treatment

  10. Th9 cells and iTregs are developmentally linked and GITR can subvert tolerogenic conditions to boost Th9 immunity.

  11. GITR is a crucial player in differentiation of thymic regulatory T cells and expansion of regulatory T cells, including both thymic regulatory T cells and peripheral regulatory T cells.

  12. enhanced GITR-triggering mediates its protective, anti-viral effect on the CD8 T cell compartment by boosting CD4 T cell help.

  13. A CD4 T cell-intrinsic role for GITR in sustaining early CD8 and late humoral responses to collectively promote control of chronic LCMV clone 13 infection.

  14. GITRL expressed on macrophages drives cytokine release and T cell activation, resulting in neuropathic pain via GITR-dependent actions. The GITRL-GITR pathway might represent a novel target for the treatment of neuropathic pain.

  15. Data show that GITR agonist antibody alters Treg lineage stability inducing an inflammatory effector T cell phenotype. The resultant loss of lineage stability causes Treg to lose their intra-tumor immune suppressive function.

  16. Gene expression in the Gitr locus is regulated by NF-kappaB and Foxp3 through an enhancer.

  17. Inhibition of GITR decreases leukocyte cell adhesion.

  18. The effects of GITR activation on Treg cells can have different outcomes depending on the experimental context ranging from expansion in normal mice to death in the Inflammatory bowel disease model.

  19. GITR triggering on CD4(+)T cells increases poststroke inflammation and decreases the number of neural stem/progenitor cells induced by ischemia (iNSPCs).

  20. these data suggest that GITR plays a role in the survival of CD8 memory phenotype T cells

Human Tumor Necrosis Factor Receptor Superfamily, Member 18 (TNFRSF18) interaction partners

  1. HTLV-1 infection can modify the expression of main functional transcription factors, FOXP3 and GITR

  2. a novel molecular mechanism by which MBD4 inhibits GITR expression in a DNMT1-dependent manner

  3. Aberrant expression of GITR may contribute to systemic lupus erithematosus pathogenesis. Glucocorticoid may achieve its therapeutic effect partly by inducing GITR expression on Tresps rather than Tregs, which initiates the apoptosis of Tresp cells in SLE patients.

  4. GITR expression can enhance the sensitivity to Bortezomib by inhibiting Bortezomib-induced NF-kappaB activation.

  5. GITR is a crucial player in differentiation of thymic regulatory T cells and expansion of regulatory T cells, including both thymic regulatory T cells and peripheral regulatory T cells.

  6. Data may suggest a key role of regulatory GITR+CD25 low/-CD4+ T cells subset in the modulation of the abnormal immune response in lupus erythematosus (SLE) patients.

  7. results suggest that the GITR rs3753348 polymorphism may be involved in the development and susceptibility of CWP.

  8. these results show a higher susceptibility to apoptosis in patients' versus controls' T(reg) cells, suggesting that GITR is a T(reg)-cell marker that would be primarily involved in T(reg)-cell survival rather than in their suppressor function.

  9. Our findings indicate the possible involvement of GITR-GITRL pathway in the pathogenesis of pSS.

  10. GITR acts as a potential tumor suppressor in MM.

  11. Data indicate that the mRNAs of CTLA-4 and GITR genes were expressed at lower levels in CVID patients compared to control group.

  12. GITR is pathologically expressed on Treg cells in systemic lupus erythematosus.

  13. Liver tumor Tregs up-regulate the expression of glucocorticoid-induced tumor necrosis factor receptor compared with Tregs in tumor-free liver tissue and blood.

  14. Results suggest that GITR expression might indicate a molecular link between steroid use and complicated acute sigmoid diverticulitis. Increased MMP-9 expression by GITR signalling might explain morphological changes in the colonic wall in diverticulitis.

  15. The regulatory SNPs identified in this study will provide useful information for understanding the relevance of sequence polymorphisms in populations of different background and may serve as a basis to study parasite susceptibility in association studies

  16. GITRL may contribute to disease pathophysiology and resistance to direct and Rituximab-induced NK reactivity in CLL

  17. GITR, which transmits a signal that abrogates regulatory T cell functions, was elevated in early rheumatoid arthritis.

  18. DCs transfected with mRNA encoding a humanized anti-CTLA-4 mAb and mRNA encoding a soluble human GITR fusion protein enhance the induction of anti-tumor CTLs in response to DCs.

  19. Findings suggest that GITR-expression of TILs is associated with cancer progression.

  20. Although GITR transgene costimulation can therapeutically enhance T helper (Th) type 2 cell responses, GITR-GITR ligand interactions are not required for development of Th2-mediated resistance or pathology.

TNFRSF18 Antigen Profile

Protein Summary

This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

Gene names and symbols associated with TNFRSF18

  • TNF receptor superfamily member 18 (TNFRSF18) antibody
  • tumor necrosis factor receptor superfamily, member 18 (Tnfrsf18) antibody
  • TNF receptor superfamily member 18 (Tnfrsf18) antibody
  • AITR antibody
  • CD357 antibody
  • Gitr antibody
  • GITR-D antibody
  • TNFRSF18 antibody

Protein level used designations for TNFRSF18

tumor necrosis factor receptor superfamily member 18 , glucocorticoid-induced TNFR-related , tumor necrosis factor receptor superfamily, member 18 , glucocorticoid-induced TNFR-related protein , TNF receptor superfamily activation-inducible protein , activation-inducible TNFR family receptor

GENE ID SPECIES
419424 Gallus gallus
516256 Bos taurus
606971 Canis lupus familiaris
699559 Macaca mulatta
741567 Pan troglodytes
21936 Mus musculus
8784 Homo sapiens
500598 Rattus norvegicus
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