KCNJ1 antibody (pSer44) (HRP)

Catalog No. ABIN1413494

The Rabbit Polyclonal anti-KCNJ1 antibody is suitable to detect KCNJ1 in samples from Human. It has been validated for ELISA, IHC (p) and IHC (fro).

Quick Overview for KCNJ1 antibody (pSer44) (HRP) (ABIN1413494)

Target: KCNJ1 (Potassium Inwardly-Rectifying Channel, Subfamily J, Member 1 (KCNJ1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KCNJ1 antibody is conjugated to HRP

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-KCNJ1 Antibody (HRP)

Binding Specificity: pSer44

Predicted Reactivity: Human,Mouse,Rat,Dog,Sheep,Horse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic phosphopeptide derived from human KCNJ1 around the phosphorylation site of Ser44

Isotype: IgG

Application Details

Application Notes: IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for KCNJ1

Target: KCNJ1 (Potassium Inwardly-Rectifying Channel, Subfamily J, Member 1 (KCNJ1))

Alternative Name: KCNJ1

Background:

Synonyms: KCNJ1 phospho S44, p-KCNJ1 phospho S44, KCNJ1 phospho Ser44, p-KCNJ1 Ser44, p-ROM-Kphospho S44, KCNJ1 phospho S25, p-KCNJ1 phospho S25, KCNJ1 phospho Ser25, p-KCNJ1 Ser25, p-ROM-Kphospho S25, ROM K, ROM-K, inwardly rectying subfamily J member 1, ATP regulated potassium channel ROM K, ATP sensitive inward rectier potassium channel 1, ATP-regulated potassium channel ROM-K, ATP-sensitive inward rectier potassium channel 1, Inward rectier K+ channel Kir1.1, inwardly rectying K+ channel, IRK1_HUMAN, KCNJ 1, KCNJ, Kcnj1, Kir 1.1, Kir1.1, Potassium channel, Potassium channel inwardly rectying subfamily J member 1, potassium inwardly-rectying channel J1, ROMK 1, ROMK 2, ROMK, ROMK1, ROMK2.

Background: Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. It is activated by internal ATP and probably plays an important role in potassium homeostasis. The encoded protein has a greater tendency to allow potassium to flow into a cell rather than out of a cell. Mutations in this gene have been associated with antenatal Bartter syndrome, which is characterized by salt wasting, hypokalemic alkalosis, hypercalciuria, and low blood pressure. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].