This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogen
This STAT3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 673-699 amino acids from the C-terminal region of human STAT3.
KO Validated
STAT3
Reactivity: Human
WB, IHC, IP, IF
Host: Rabbit
Monoclonal
unconjugated
Application Notes
WB: 1:1000
Restrictions
For Research Use only
Format
Liquid
Buffer
Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
4 °C,-20 °C
Expiry Date
6 months
Yin, Du, Cao, Liu, Xu, Xiang: "Reg3g Promotes Pancreatic Carcinogenesis in a Murine Model of Chronic Pancreatitis." in: Digestive diseases and sciences, (2015) (PubMed).
Li, Cheung, Evans, Shaw: "Modulation of gene expression and tumor cell growth by redox modification of STAT3." in: Cancer research, Vol. 70, Issue 20, pp. 8222-32, (2010) (PubMed).
Takaishi, Komohara, Tashiro, Ohtake, Nakagawa, Katabuchi, Takeya: "Involvement of M2-polarized macrophages in the ascites from advanced epithelial ovarian carcinoma in tumor progression via Stat3 activation." in: Cancer science, Vol. 101, Issue 10, pp. 2128-36, (2010) (PubMed).
Li, Zou, Li: "Up-regulation of signal transducer and activator of transcription-3 is associated with aggravation of ulcerative colitis." in: The surgeon : journal of the Royal Colleges of Surgeons of Edinburgh and Ireland, Vol. 8, Issue 5, pp. 262-6, (2010) (PubMed).
Schimke, Sawalle-Belohradsky, Roesler, Wollenberg, Rack, Borte, Rieber, Cremer, Maass, Dopfer, Reichenbach, Wahn, Hoenig, Jansson, Roesen-Wolff, Schaub, Seger, Hill, Ochs, Torgerson et al.: "Diagnostic approach to the hyper-IgE syndromes: immunologic and clinical key findings to differentiate hyper-IgE syndromes from atopic dermatitis...." in: The Journal of allergy and clinical immunology, Vol. 126, Issue 3, pp. 611-7.e1, (2010) (PubMed).
Iliopoulos, Jaeger, Hirsch, Bulyk, Struhl: "STAT3 activation of miR-21 and miR-181b-1 via PTEN and CYLD are part of the epigenetic switch linking inflammation to cancer." in: Molecular cell, Vol. 39, Issue 4, pp. 493-506, (2010) (PubMed).
Target
STAT3
(Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3))
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Background
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Three alternatively spliced transcript variants encoding distinct isoforms have been described.