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GSK3 alpha antibody (N-Term)
GSK3a
Reactivity: Human, Mouse, Rat
WB
Host: Mouse
Monoclonal
SBGSK3a1
unconjugated
Product Details anti-GSK3 alpha Antibody
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Target
See all GSK3 alpha (GSK3a) Antibodies
GSK3 alpha (GSK3a)
(Glycogen Synthase Kinase 3 alpha (GSK3a))
Binding Specificity
All epitopes for GSK3 alpha antibodies
N-Term
Reactivity
All reactivities for GSK3 alpha antibodies
Human, Mouse, Rat
Host
All hosts for GSK3 alpha antibodies
Mouse
Clonality
All clonalities for GSK3 alpha antibodies
Monoclonal
Conjugate
All conjugates for GSK3 alpha antibodies
This GSK3 alpha antibody is un-conjugated
Application
All applications for GSK3 alpha antibodies
Western Blotting (WB)
Specificity
Human/Mouse GSK-3α
Characteristics
Mouse Anti-GSK-3a-UNLB
Purification
Purified
Immunogen
Recombinant N-terminal GSK-3alpha
Clone
SBGSK3a1
Isotype
IgG2a
Top Product
Discover our top product GSK3a Primary Antibody
Alternatives
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Application Details
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Application Notes
Applications: WB - Quality tested Working Dilutions: Immunoblotting Purified (UNLB) antibody ≤ 2 g/mL HRP conjugate 1:1,000 - 1:5,000
Sample Volume
0,2 mL
Restrictions
For Research Use only
Handling
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Concentration
0.5 mg/mL
Buffer
0.1 mg of purified immunoglobulin in 0.2 mL of borate buffered saline, pH 8.2. No preservatives or amine-containing buffer salts added
Preservative
Without preservative
Handling Advice
Each reagent is stable for the period shown on the bottle label if stored as directed.
Storage
4 °C
Storage Comment
Store at 2-8°C
Target Details for GSK3 alpha
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Target
GSK3 alpha (GSK3a)
(Glycogen Synthase Kinase 3 alpha (GSK3a))
Alternative Name
GSK-3a (GSK3a Products )
Synonyms
2700086H06Rik antibody, GSK3A antibody, GSK-3[a] antibody, GSK-3[b] antibody, GSK3 antibody, gsk3a antibody, xgsk3 antibody, glycogen synthase kinase 3 alpha antibody, glycogen synthase kinase 3 alpha b antibody, glycogen synthase kinase 3 alpha S homeolog antibody, GSK3A antibody, Gsk3a antibody, gsk3a antibody, gsk3ab antibody, gsk3a.S antibody, Bm1_31380 antibody
Background
Glycogen synthase kinase-3 (GSK-3) is a protein serine kinase that phosphorylates glycogen synthase and thereby inactivates it. Insulin stimulates the dephosphorylation of glycogen synthase at the sites phosphorylated by GSK-3 and subsequently inhibits GSK-3 acutely leading to the stimulation of glycogen synthesis. GSK-3 signaling is performed by two isoforms, GSK-3 α and GSK-3β. The two isoforms share 97 % sequence similarity within their catalytic domains. GSK-3 has also been shown to play a role in protein synthesis, cell adhesion, cell proliferation, cell differentiation, microtubule dynamics and cell motility.
Pathways
PI3K-Akt Signaling , WNT Signaling , Fc-epsilon Receptor Signaling Pathway , EGFR Signaling Pathway , Neurotrophin Signaling Pathway , cAMP Metabolic Process , Cellular Glucan Metabolic Process , Regulation of Muscle Cell Differentiation , Regulation of G-Protein Coupled Receptor Protein Signaling , ER-Nucleus Signaling , Regulation of Carbohydrate Metabolic Process , BCR Signaling , Warburg Effect
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