ABCA4 antibody (ATP-Binding Cassette, Sub-Family A (ABC1), Member 4) (Internal Region)

Details for Product anti-ABCA4 Antibody No. ABIN4889494, Supplier: Log in to see
Antigen
  • ABC10
  • ABCR
  • ARMD2
  • CORD3
  • FFM
  • RMP
  • RP19
  • STGD
  • STGD1
  • AW050280
  • Abc10
  • Abcr
  • D430003I15Rik
  • RmP
  • abcr
  • ffm
  • rmp
  • rp19
  • stgd
  • abc10
  • armd2
  • cord3
  • stgd1
  • zgc:91823
  • ATP binding cassette subfamily A member 4
  • ATP-binding cassette, sub-family A (ABC1), member 4
  • ATP binding cassette subfamily A member 4 L homeolog
  • ATP-binding cassette, sub-family A (ABC1), member 4a
  • ABCA4
  • Abca4
  • abca4
  • abca4.L
  • abca4a
Epitope
Internal Region
21
2
2
2
2
2
2
1
1
1
1
1
1
1
1
Reactivity
Human
56
21
13
6
6
5
4
1
1
1
Host
Rabbit
31
28
8
Clonality
Polyclonal
Conjugate
This ABCA4 antibody is un-conjugated
3
2
2
2
2
2
Application
ELISA, Immunohistochemistry (IHC), Western Blotting (WB)
35
33
18
3
2
2
1
1
Options
Supplier
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Immunogen Synthetic peptide derived from internal domain of human ABCA4 protein.
Specificity Reacts with human ABCA4 protein
Purification Purified (protein A)
Plasmids, Primers & others Plasmids, Primers & others ABCA4 products on genomics-online (e.g. as negative or positive controls)
Antigen
Alternative Name Retinal-Specific ATP-Binding Cassette Transporter (ABCA4 Antibody Abstract)
Background Defects in ABCA4 are the cause of Stargardt disease type 1 (STGD1) . In the visual cycle, acts as an inward-directed retinoid flipase, retinoid substrates imported by ABCA4 from the extracellular or intradiscal (rod) membrane surfaces to the cytoplasmic membrane surface are all-trans-retinaldehyde (ATR) and N-retinyl-phosphatidyl-ethanolamine (NR-PE). Once transported to the cytoplasmic surface, ATR is reduced to vitamin A by trans-retinol dehydrogenase (tRDH) and then transferred to the retinal pigment epithelium (RPE) where it is converted to 11-cis-retinal. May play a role in photoresponse, removing ATR/NR-PE from the extracellular photoreceptor surfaces during bleach recovery.
UniProt P78363
Application Notes

Working dilution: Optimal dilutions should be determined by the end user.
The following are guidelines only :
- WB : 1 to 5 μg/mL - IHC : 1/100 to 1/1000

Restrictions For Research Use only
Format Lyophilized
Reconstitution Must be reconstituted in distilled water.
Concentration 1 mg/mL
Buffer Tris 0,1M, glycine 0,1M, sucrose 2 %
Storage 4 °C/-20 °C
Storage Comment Lyophilized powder stable for a minimum of 2 years at -20°C. Store reconstituted antibodies at +4°C. For extended periods store in aliquots at -20°C. Antibodies are guaranteed for 6 month from date of receipt.
Expiry Date 24 months
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