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Tuberin antibody (pSer1254)
TSC2
Reactivity: Human
IHC (p)
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-Tuberin Antibody
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Target
See all Tuberin (TSC2) Antibodies
Tuberin (TSC2)
(Tuberous Sclerosis 2 (TSC2))
Binding Specificity
All epitopes for Tuberin antibodies
pSer1254
Reactivity
All reactivities for Tuberin antibodies
Human
Host
All hosts for Tuberin antibodies
Rabbit
Clonality
All clonalities for Tuberin antibodies
Polyclonal
Conjugate
All conjugates for Tuberin antibodies
This Tuberin antibody is un-conjugated
Application
All applications for Tuberin antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Specificity
This antibody detects endogenous levels of p-Tsc2 protein only when phosphorylated at Ser1254.
Cross-Reactivity (Details)
Species reactivity (tested):Human.
Purification
Affinity chromatography
Purity
> 95 % by SDS-PAGE
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Alternatives
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Application Details
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Application Notes
Immunohistochemistry: 1/50 - 1/200. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions
For Research Use only
Handling
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Concentration
1,0 mg/mL
Buffer
Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide
Preservative
Sodium azide
Precaution of Use
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice
Avoid repeated freezing and thawing.
Storage
4 °C/-20 °C
Storage Comment
Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Target Details for Tuberin
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Target
Tuberin (TSC2)
(Tuberous Sclerosis 2 (TSC2))
Alternative Name
Tuberin / TSC2 (TSC2 Products )
Synonyms
TSC2 antibody, fc16b02 antibody, tuberin antibody, wu:fc16b02 antibody, LAM antibody, TSC4 antibody, Nafld antibody, Tcs2 antibody, Rc antibody, TSC complex subunit 2 antibody, tuberin antibody, hypothetical protein antibody, tuberous sclerosis 2 antibody, TSC2 antibody, LOC5569538 antibody, tsc2 antibody, PGTG_00159 antibody, Tsc2 antibody
Background
Tuberin, or TSC2 (Tuberous sclerosis complex), is implicated as a tumor suppressor. It may function in vesicular transport, and may also play a role in the regulation of cell growth arrest and in the regulation of transcription mediated by steroid receptors. Interaction between hamartin (TSC1) and tuberin may facilitate vesicular docking. It specifically stimulates the intrinsic GTPase activity of the Ras related protein RAP1A and RAB5, suggesting a possible mechanism for its role in regulating cellular growth. Mutations in tuberin lead to constitutive activation of RAP1A in tumors. At least three isoforms of Tuberin exist.Synonyms: TSC4, Tuberous sclerosis 2 protein
Molecular Weight
approx. 200 kDa
Gene ID
7249
NCBI Accession
NP_000539
UniProt
P49815
Pathways
RTK Signaling , AMPK Signaling , Fc-epsilon Receptor Signaling Pathway , EGFR Signaling Pathway , Neurotrophin Signaling Pathway , Regulation of Cell Size , Tube Formation , Protein targeting to Nucleus
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