PDK2 antibody (Pyruvate Dehydrogenase Kinase, Isozyme 2)

Details for Product anti-PDK2 Antibody No. ABIN6944475
Antigen
  • PDHK2
  • PDKII
  • Pdk
  • zgc:56209
  • PDK2
  • pyruvate dehydrogenase kinase 2
  • pyruvate dehydrogenase kinase, isoenzyme 2
  • pyruvate dehydrogenase kinase, isozyme 2b
  • PDK2
  • Pdk2
  • pdk2b
Reactivity
Human, Mouse (Murine), Rat (Rattus)
149
103
64
11
5
2
2
2
1
1
1
1
1
1
Host
Rabbit
127
42
Clonality (Clone)
Monoclonal ()
Conjugate
This PDK2 antibody is un-conjugated
11
9
9
8
8
8
3
3
3
3
3
3
1
1
1
1
1
Application
Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
141
101
76
31
20
13
5
4
4
2
1
1
1
Options
Immunogen Recombinant protein within human PDK2 aa 200-400
Clone 2F4
Isotype IgG
Purification Purified by Protein A.
Plasmids, Primers & others Plasmids, Primers & others PDK2 products on genomics-online (e.g. as negative or positive controls)
Antigen
Alternative Name PDK2 (PDK2 Antibody Abstract)
Background

Kinase that plays a key role in the regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Inhibition of pyruvate dehydrogenase decreases glucose utilization and increases fat metabolism. Mediates cellular responses to insulin. Plays an important role in maintaining normal blood glucose levels and in metabolic adaptation to nutrient availability. Via its regulation of pyruvate dehydrogenase activity, plays an important role in maintaining normal blood pH and in preventing the accumulation of ketone bodies under starvation. Plays a role in the regulation of cell proliferation and in resistance to apoptosis under oxidative stress. Plays a role in p53/TP53-mediated apoptosis.

Subcellular location: Mitochondrion


Synonyms: Pyruvate dehydrogenase (acetyl-transferring) kinase isozyme 2 mitochondrial, Pyruvate dehydrogenase kinase 2, PDH kinase 2, PDKII, PDK2, PDHK2
Gene ID 5164
UniProt Q15119
Pathways PI3K-Akt Signaling, RTK Signaling, Carbohydrate Homeostasis, Regulation of Carbohydrate Metabolic Process
Application Notes WB(1:500-2000), FCM(1:50-100), IHC-P(1:50-200)
Restrictions For Research Use only
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Expiry Date 12 months
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