STAT3 antibody (Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor)) (AA 685-725) (FITC)

Details for Product anti-STAT3 Antibody No. ABIN732645, Supplier: Log in to see
Antigen
  • 1110034C02Rik
  • AW109958
  • Aprf
  • APRF
  • HIES
  • Xstat3
  • aprf
  • hies
  • stat3
  • wu:fc15d02
  • wu:fl59g06
  • z-Stat3
  • signal transducer and activator of transcription 3
  • signal transduction and activation of transcription 3
  • signal transducer and activator of transcription 3, gene 1 L homeolog
  • signal transducer and activator of transcription 3 (acute-phase response factor)
  • STAT3
  • stat3
  • Stat3
  • stat3.1.L
Alternatives
anti-Human STAT3 antibody for Western Blotting
Epitope
AA 685-725, pTyr705
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Reactivity
Human, Mouse (Murine), Pig (Porcine), Rat (Rattus)
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Host
Rabbit
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Clonality
Polyclonal
Conjugate
This STAT3 antibody is conjugated to FITC
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Application
Flow Cytometry (FACS), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
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Options
Supplier
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Supplier Product No.
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Immunogen KLH conjugated synthetic phosphopeptide derived from human STAT3 around the phosphorylation site of Tyr705
Isotype IgG
Purification Purified by Protein A.
Alternative Name Stat3 (STAT3 Antibody Abstract)
Background

Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA. Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity. Plays an important role in host defense in methicillin-resistant S.aureus lung infection by regulating the expression of the antimicrobial lectin REG3G (By similarity).

Subcellular location: Cytoplasm, Nucleus

Synonyms: APRF, HIES, ADMIO, Signal transducer and activator of transcription 3, Acute-phase response factor, STAT3

Gene ID 6774
UniProt P40763
Pathways JAK-STAT Signaling, RTK Signaling, Interferon-gamma Pathway, Neurotrophin Signaling Pathway, Dopaminergic Neurogenesis, Response to Growth Hormone Stimulus, Carbohydrate Homeostasis, Stem Cell Maintenance, Hepatitis C, Protein targeting to Nucleus, Feeding Behaviour, CXCR4-mediated Signaling Events, Signaling of Hepatocyte Growth Factor Receptor
Application Notes FCM 1:20-100
IF(IHC-P) 1:50-200
Restrictions For Research Use only
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store at 4°C
Expiry Date 12 months
Supplier Images
Flow Cytometry (FACS) image for anti-Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) (AA 685-725), (pTyr705) antibody (FITC) (ABIN732645) This image has been kindly submitted by TÜbingen Ageing and Tumour Immunology Group (...
Product cited in: Iriyama, Hatta, Takei: "Direct effect of dasatinib on signal transduction pathways associated with a rapid mobilization of cytotoxic lymphocytes." in: Cancer medicine, Vol. 5, Issue 11, pp. 3223-3234, 2016 (PubMed). Method employed by authors: Flow Cytometry (FACS) (Sample species: Human). Further details: Sample: blood, Mononuclear cells

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