×
For best experience we recommend to activate Javascript in your browser.
MDM2 antibody (AA 18-22)
MDM2
Reactivity: Human
WB
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-MDM2 Antibody
(hide)
Target
See all MDM2 Antibodies
MDM2
(Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) (MDM2))
Binding Specificity
All epitopes for MDM2 antibodies
AA 18-22
Reactivity
All reactivities for MDM2 antibodies
Human
Host
All hosts for MDM2 antibodies
Rabbit
Clonality
All clonalities for MDM2 antibodies
Polyclonal
Conjugate
All conjugates for MDM2 antibodies
This MDM2 antibody is un-conjugated
Application
All applications for MDM2 antibodies
Western Blotting (WB)
Specificity
The antibody detects endogenous levels of total MDM2 protein.
Purification
Affinity purified
Immunogen
Peptide sequence around AA 18-22 (Q-I-P-A-S) derived from Human MDM2. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.
Top Product
Discover our top product MDM2 Primary Antibody
Alternatives
(show)
Application Details
(hide)
Application Notes
Western blotting: 1:500-1:1000
Restrictions
For Research Use only
Handling
(hide)
Format
Liquid
Concentration
1 mg/mL
Buffer
Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Preservative
Sodium azide
Precaution of Use
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
4 °C/-20 °C
Storage Comment
Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
Target Details for MDM2
(hide)
Target
MDM2
(Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) (MDM2))
Alternative Name
MDM2 (MDM2 Products )
Synonyms
ACTFS antibody, HDMX antibody, hdm2 antibody, zgc:109834 antibody, 1700007J15Rik antibody, AA415488 antibody, Mdm-2 antibody, MDM2 proto-oncogene antibody, MDM2 proto-oncogene S homeolog antibody, Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse) antibody, MDM2 oncogene, E3 ubiquitin protein ligase antibody, transformed mouse 3T3 cell double minute 2 antibody, MDM2 antibody, mdm2.S antibody, Mdm2 antibody, mdm2 antibody
Background
MDM2, a ubiquitin ligase for p53, plays a central role in regulation of the stability of p53 . Akt-mediated phosphorylation of MDM2 at Ser166 and Ser186 increases its interaction with p300, allowing MDM2-mediated ubiquitination and degradation of p53 . Phosphorylation of MDM2 also blocks its binding to p19ARF, increasing the degradation of p53 .
Molecular Weight
90 kDa
Gene ID
4193
NCBI Accession
NP_002383
UniProt
Q00987
Pathways
p53 Signaling , PI3K-Akt Signaling , Cell Division Cycle , Fc-epsilon Receptor Signaling Pathway , EGFR Signaling Pathway , Neurotrophin Signaling Pathway , Autophagy , Ubiquitin Proteasome Pathway
Recently viewed
(hide)