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|Antigen||Caspase 4, Apoptosis-Related Cysteine Peptidase (CASP4) Antibodies|
|Reactivity||Human, Mouse (Murine) Alternatives|
|Conjugate||This Caspase 4 antibody is un-conjugated Alternatives|
ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Microarray (MA), Western Blotting (WB)
|29 references available|
|Supplier||Log in to see|
Product Details anti-Caspase 4 AntibodyTarget Details Caspase 4 Application Details Handling References for anti-Caspase 4 antibody (ABIN265762) Images
|Purification||Protein G purified|
|Immunogen||A recombinant p30 subunit of mouse Caspase 11. [UniProt# P70343]|
|Plasmids, Primers & others|
Target Details Caspase 4Product Details anti-Caspase 4 Antibody Application Details Handling References for anti-Caspase 4 antibody (ABIN265762) Images back to top
|Alternative Name||Caspase-11 (CASP4 Antibody Abstract)|
|Background||Gene Symbol: CASP11|
|Molecular Weight||Theoretical MW: 35-43 kDa|
|Pathways||Apoptosis, Caspase Cascade in Apoptosis, Positive Regulation of Endopeptidase Activity|
Application DetailsProduct Details anti-Caspase 4 Antibody Target Details Caspase 4 Handling References for anti-Caspase 4 antibody (ABIN265762) Images back to top
|Application Notes||Western Blot 5 μg/mL, ELISA, Immunohistochemistry 1:10-1:500, Immunocytochemistry/Immunofluorescence 1:100, Immunoprecipitation, Immunohistochemistry-Paraffin 1:100, Immunohistochemistry-Frozen 1:10-1:500, MicroarrayUse in immunprecipitation reported in scientific literature (PMID 10791975) The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.|
The antibodies are intended for use in vitro experiments only. Our antibodies have not been tested nor are recommended for use in vivo.
|Restrictions||For Research Use only|
HandlingProduct Details anti-Caspase 4 Antibody Target Details Caspase 4 Application Details References for anti-Caspase 4 antibody (ABIN265762) Images back to top
Buffer contains: 0.02 % Sodium Azide
|Precaution of Use||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Avoid freeze-thaw cycles|
|Storage||4 °C,-20 °C|
|Storage Comment||Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.|
References for anti-Caspase 4 antibody (ABIN265762)Product Details anti-Caspase 4 Antibody Target Details Caspase 4 Application Details Handling Images back to top
|Product cited in:||
Quach, Moreau, Sandall, Chadee: "Entamoeba histolytica-induced IL-1β secretion is dependent on caspase-4 and gasdermin D." in: Mucosal immunology, Vol. 12, Issue 2, pp. 323-339, 2019 Method employed by authors: Immunoprecipitation (IP) (Sample species: Human).
Kolb, Phan, Borcherding, Liu, Yuan, Janowski, Xie, Markan, Li, Potthoff, Fuentes-Mattei, Ellies, Knudson, Lee, Yeung, Cassel, Sutterwala, Zhang: "Obesity-associated NLRC4 inflammasome activation drives breast cancer progression." in: Nature communications, Vol. 7, pp. 13007, 2018
Deigendesch, Zychlinsky, Meissner: "Copper Regulates the Canonical NLRP3 Inflammasome." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 200, Issue 5, pp. 1607-1617, 2018
Balakrishnan, Karki, Berwin, Yamamoto, Kanneganti: "Guanylate binding proteins facilitate caspase-11-dependent pyroptosis in response to type 3 secretion system-negative Pseudomonas aeruginosa." in: Cell death discovery, Vol. 5, pp. 3, 2018
Man, Karki, Briard, Burton, Gingras, Pelletier, Kanneganti: "Differential roles of caspase-1 and caspase-11 in infection and inflammation." in: Scientific reports, Vol. 7, pp. 45126, 2017 (Sample species: Mouse (Murine)).
Jin, Oda, Chen, Yang, Zhou, Kang, Valentine, Kefauver, Liao, Zhang, Gonzalez-Martin, Shepherd, Morgan, Mondala, Head, Kim, Xiao, Fu, Liu, Han, Williamson, Xiao: "Differential Sensitivity of Target Genes to Translational Repression by miR-17~92." in: PLoS genetics, Vol. 13, Issue 2, pp. e1006623, 2017 Method employed by authors: Western Blotting (WB) (Sample species: Mouse (Murine)).
Cheng, Xiong, Ye, Hong, Di, Tsang, Gao, An, Mittal, Vogel, Miao, Rehman, Malik: "Caspase-11-mediated endothelial pyroptosis underlies endotoxemia-induced lung injury." in: The Journal of clinical investigation, Vol. 127, Issue 11, pp. 4124-4135, 2017 Method employed by authors: Western Blotting (WB) (Sample species: Mouse (Murine)).
Kerur, Fukuda, Banerjee, Kim, Fu, Apicella, Varshney, Yasuma, Fowler, Baghdasaryan, Marion, Huang, Yasuma, Hirano, Serbulea, Ambati, Ambati, Kajiwara, Ambati, Hirahara, Bastos-Carvalho, Ogura et al.: "cGAS drives noncanonical-inflammasome activation in age-related macular degeneration. ..." in: Nature medicine, Vol. 24, Issue 1, pp. 50-61, 2017 (Sample species: Human).
Man, Karki, Sasai, Place, Kesavardhana, Temirov, Frase, Zhu, Malireddi, Kuriakose, Peters, Neale, Brown, Yamamoto, Kanneganti: "IRGB10 Liberates Bacterial Ligands for Sensing by the AIM2 and Caspase-11-NLRP3 Inflammasomes." in: Cell, Vol. 167, Issue 2, pp. 382-396.e17, 2017
Chung, Vilaysane, Lau, Stahl, Morampudi, Bondzi-Simpson, Platnich, Bracey, French, Beck, Chun, Vallance, Muruve: "NLRP3 regulates a non-canonical platform for caspase-8 activation during epithelial cell apoptosis." in: Cell death and differentiation, Vol. 23, Issue 8, pp. 1331-46, 2016 (Sample species: Mouse (Murine)). Further details: Western Blotting
Kim, Bae, Ryu, Kwon, Oh, Kwon, Moon, Kim, Miyawaki, Lee, Shin, Kim, Kim, Ryter, Choi, Rhee, Ryu, Yoon: "SESN2/sestrin2 suppresses sepsis by inducing mitophagy and inhibiting NLRP3 activation in macrophages." in: Autophagy, Vol. 12, Issue 8, pp. 1272-91, 2016 Further details: Western Blotting,Immunoprecipitation
Klaska, Muckersie, Martin-Granados, Christofi, Forrester: "Lipopolysaccharide-primed heterotolerant dendritic cells suppress experimental autoimmune uveoretinitis by multiple mechanisms." in: Immunology, Vol. 150, Issue 3, pp. 364-377, 2016
Youm, Nguyen, Grant, Goldberg, Bodogai, Kim, DAgostino, Planavsky, Lupfer, Kanneganti, Kang, Horvath, Fahmy, Crawford, Biragyn, Alnemri, Dixit: "The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease." in: Nature medicine, Vol. 21, Issue 3, pp. 263-9, 2015 (Sample species: Human). Further details: Western Blotting
Aachoui, Kajiwara, Leaf, Mao, Ting, Coers, Aderem, Buxbaum, Miao: "Canonical Inflammasomes Drive IFN-γ to Prime Caspase-11 in Defense against a Cytosol-Invasive Bacterium." in: Cell host & microbe, Vol. 18, Issue 3, pp. 320-32, 2015 (Sample species: Mouse (Murine)). Further details: Western Blotting
Shi, Zhao, Wang, Shi, Wang, Huang, Zhuang, Cai, Wang, Shao: "Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death." in: Nature, Vol. 526, Issue 7575, pp. 660-5, 2015 (Sample species: Mouse (Murine)). Further details: Western Blotting
Kayagaki, Stowe, Lee, ORourke, Anderson, Warming, Cuellar, Haley, Roose-Girma, Phung, Liu, Lill, Li, Wu, Kummerfeld, Zhang, Lee, Snipas, Salvesen, Morris, Fitzgerald, Zhang, Bertram, Goodnow, Dixit: "Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling." in: Nature, Vol. 526, Issue 7575, pp. 666-71, 2015 (Sample species: Mouse (Murine)). Further details: Western Blotting
Diabate, Munro, Garcia, Jacquel, Michel, Obba, Goncalves, Luci, Marchetti, Demon, Degos, Bechah, Mege, Lamkanfi, Auberger, Gorvel, Stuart, Landraud, Lemichez, Boyer: "Escherichia coli ?-hemolysin counteracts the anti-virulence innate immune response triggered by the Rho GTPase activating toxin CNF1 during bacteremia." in: PLoS pathogens, Vol. 11, Issue 3, pp. e1004732, 2015 (Sample species: Mouse (Murine)). Further details: ELISA
Bonora, Wieckowsk, Chinopoulos, Kepp, Kroemer, Galluzzi, Pinton: "Molecular mechanisms of cell death: central implication of ATP synthase in mitochondrial permeability transition." in: Oncogene, Vol. 34, Issue 12, pp. 1608, 2015
Demon, Kuchmiy, Fossoul, Zhu, Kanneganti, Lamkanfi: "Caspase-11 is expressed in the colonic mucosa and protects against dextran sodium sulfate-induced colitis." in: Mucosal immunology, Vol. 7, Issue 6, pp. 1480-91, 2015
Yuan, Syed, Panchal, Joo, Colonna, Brantly, Sadikot: "Triggering receptor expressed on myeloid cells 1 (TREM-1)-mediated Bcl-2 induction prolongs macrophage survival." in: The Journal of biological chemistry, Vol. 289, Issue 21, pp. 15118-29, 2014 (Sample species: Mouse (Murine)). Further details: Western Blotting
ImagesProduct Details anti-Caspase 4 Antibody Target Details Caspase 4 Application Details Handling References for anti-Caspase 4 antibody (ABIN265762) back to top