anti-Mouse (Murine) Teratocarcinoma-Derived Growth Factor 1 antibody for Immunohistochemistry

Recommended Teratocarcinoma-Derived Growth Factor 1 Antibody (supplied by: Log in to see )

Antigen
Teratocarcinoma-Derived Growth Factor 1 (TDGF1) Antibodies
  • CR
  • CRGF
  • CRIPTO
  • CR1
  • cripto
  • cb85
  • tdgf1
  • wu:fe01d04
  • zgc:109829
  • Cripto-1
  • cr1
  • cr1a
  • frl-1
  • frl1
  • xcr1
  • TDGF1
  • tdgf3
  • cripto-3
  • teratocarcinoma-derived growth factor 1
  • teratocarcinoma-derived growth factor 1, member 3 L homeolog
  • teratocarcinoma-derived growth factor 1, member 1
  • TDGF1
  • Tdgf1
  • tdgf1
  • tdgf1.3.L
  • tdgf1.1
Reactivity
Mouse (Murine), Rat (Rattus), Human
193
81
52
2
2
Host
Rabbit
140
44
25
14
Clonality
Polyclonal
Conjugate
Un-conjugated
18
18
17
9
8
8
8
5
5
5
5
4
4
4
4
4
4
4
4
3
3
3
3
1
1
1
Application
Immunohistochemistry (IHC), Western Blotting (WB)
105
81
61
52
37
24
23
17
5
2
2
1
1
1
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Catalog No. ABIN3021342
$ 393.25
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
13 ABIN2989094 IHC WB Rabbit IgG Log in to see Polyclonal 0
12.992776 ABIN5965457 IHC WB Rabbit IgG Log in to see Polyclonal 0
9.992776 ABIN6265513 ELISA IHC WB Rabbit IgG Log in to see Polyclonal 0
9.992776 ABIN2434504 IHC ELISA Rabbit IgG Log in to see Polyclonal 0
1 ABIN2562007 IHC ELISA Goat IgG Internal Region Log in to see Polyclonal 0

General

Antigen Teratocarcinoma-Derived Growth Factor 1 (TDGF1) Antibodies
Reactivity Mouse (Murine), Rat (Rattus), Human
(193), (81), (52), (2), (2)
Host Rabbit
(140), (44), (25), (14)
Clonality
Polyclonal
Conjugate Un-conjugated
(18), (18), (17), (9), (8), (8), (8), (5), (5), (5), (5), (4), (4), (4), (4), (4), (4), (4), (4), (3), (3), (3), (3), (1), (1), (1)
Application Immunohistochemistry (IHC), Western Blotting (WB)
(105), (81), (61), (52), (37), (24), (23), (17), (5), (2), (2), (1), (1), (1)
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Product details

Target Details Application Details Handling Images
Purification Affinity purification
Immunogen Recombinant protein of human TDGF1
Isotype IgG

Target Details

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Antigen
Alternative Name TDGF1 (TDGF1 Antibody Abstract)
Background Cripto, also known as teratocarcinoma derived growth factor 1 (TDGF-1), belongs to the EGF-CFC family of proteins. Members of this family are characterized by an N-terminal signal peptide, a conserved cysteine rich domain (CFC motif), and a short hydrophobic carboxy-terminal tail that contains GPI cleavage and attachment sites. The GPI moiety anchors Cripto and family members to the extracellular plasma membrane. An O-linked fucosylation site within the EGF-like motif is required for Cripto and related family members to perform their function as co-receptors for TGF-beta-related ligands such as Nodal and Vg1/GDF1. Soluble forms of Cripto can be produced - these contain intact EGF and CFC domains, and are thought to have paracrine activities, as opposed to the autocrine activity of Cripto functioning as a coreceptor. Understanding of this paracrine activity is not complete, but it is proposed that Cripto may act as co-ligand for Nodal.Cripto is an important modulator of embryogenesis and oncogenesis. It is highly expressed in early embryos, and in embryonic stem (ES) cells where it is involved in cardiomyocytic differentiation and acts as a negative regulator of neurogenesis. Transient activation of Cripto is essential for the capacity of stem cell self-renewal and pluripotency in ES cells, and in some adult derived stem cells. Signaling through Cripto can also stimulate other activities that promote tumorigenesis such as stimulation of proliferation, cell motility, invasion, angiogenesis and epithelial-mesenchymal transition (EMT). Cripto is highly expressed in a broad range of tumors, where it acts as a potent oncogene.
Synonyms: TDGF1, CR, CRGF, CRIPTO, Cripto-1
Gene ID 6997
UniProt P13385
Pathways EGFR Signaling Pathway

Application Details

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Application Notes Recommended dilutions: WB: 1:500-1:2000, IHC: 1:50-1:200
Restrictions For Research Use only

Handling

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Format Liquid
Buffer PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid freeze / thaw cycles
Storage -20 °C/-80 °C

Images

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Supplier Images
Western Blotting (WB) image for anti-Teratocarcinoma-Derived Growth Factor 1 (TDGF1) antibody (ABIN3021342) Western blot analysis of NCCIT cell lysate using TDGF1 antibody.