anti-Chicken STAT1 antibody for Intracellular Staining
Recommended STAT1 Antibody
- Antigen
-
Signal Transducer and Activator of Transcription 1, 91kDa (STAT1) Antibodies
show synonyms for this antigen- CANDF7
- ISGF-3
- STAT91
- 2010005J02Rik
- AA408197
- XStat1
- STAT4
- DD6G4-4
- STAT
- STAT1
- dZ182H3.3
- si:by134g18.2
- si:by51f19.1
- si:dz182h3.3
- si:dz199m19.1
- si:dz73o4.2
- stat1
- signal transducer and activator of transcription 1
- signal transducer and activator of transcription 1 L homeolog
- signal transducer and activator of transcription 1, 91kDa
- signal transducer and activator of transcription 4
- signal transducer and activator of transcription 1a
- STAT1
- Stat1
- stat1.L
- stat4
- stat1a
- Epitope
-
AA 1-194, N-Term
Alternatives - Reactivity
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Chicken, Dog (Canine), Frog, Human, Mouse (Murine), Rat (Rattus)
Alternatives - Host
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Mouse
Alternatives - Clonality
- Conjugate
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This STAT1 antibody is conjugated to PE
Alternatives - Application
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Intracellular Staining (ICS)
Alternatives - Options
Catalog No. ABIN1176937
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Relevance Score | ABIN | Application | Conjugate | Host | Isotype | Epitope | Clonality | References | Details |
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8.5 | ABIN1176938 | ICS | Alexa Fluor 647 | Mouse | IgG1 | AA 1-194, N-Term | 1-Stat1 | 1 |
General |
|
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Antigen | Signal Transducer and Activator of Transcription 1, 91kDa (STAT1) Antibodies |
Epitope | AA 1-194, N-Term Alternatives |
Reactivity | Chicken, Dog (Canine), Frog, Human, Mouse (Murine), Rat (Rattus) Alternatives |
Host | Mouse Alternatives |
Clonality (Clone) | |
Conjugate | This STAT1 antibody is conjugated to PE Alternatives |
Application |
Intracellular Staining (ICS)
Alternatives
|
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1 reference available |
Supplier | |
Product Details anti-STAT1 AntibodyTarget Details STAT1 Application Details Handling References for anti-STAT1 antibody (ABIN1176937) Images |
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Brand | BD Phosflow™ |
Purification | The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography. |
Immunogen | Human Stat1 aa. 1-194 |
Clone | 1-Stat1 |
Isotype | IgG1 |
Plasmids, Primers & others | |
Target Details STAT1Product Details anti-STAT1 Antibody Application Details Handling References for anti-STAT1 antibody (ABIN1176937) Images back to top |
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Antigen | |
Alternative Name | Stat1 (STAT1 Antibody Abstract) |
Background | Stat (Signal transducer and activators of transcription) proteins are critical mediators of the biologic activity of cytokines, including interleukins, interferons, erythropoietin, and growth factors. Ligand-receptor interaction leads to activation of constitutively associated JAK family kinases and subsequent recruitment/activation of Stat proteins by tyrosine phosphorylation. Active Stat proteins then move to the nucleus to promote transcription of cytokine-inducible genes. Seven Stat proteins have been cloned, each of which is differentially expressed and/or activated in a cytokine-specific and cell type-specific manner. Stat1 and Stat2 are components of the ISGF3 (Interferon-Stimulated Gene Factor 3) complex, which is the primary transcription activator induced by the binding of the interferon to a specific cell-surface receptor. Stat1 has two alternatively spliced isoforms, 91-kDa Stat1alpha and 84 kDa Stat1beta, Stat1alpha has 38 additional C-terminal amino acids. In response to the binding of IFNalpha, IFNgamma, EGF, PDGF, or CSF-1 to their respective receptors, the Stat1 subunits become tyrosine-phosphorylated at Y701, and the complex is translocated to the nucleus. This results in the formation of an active complex that includes the DNA-binding p48 subunit. This complex is responsible for modulating the transcription of the interferon-stimulated genes (ISGs). Thus, phosphorylation of Y701 in Stat1 occurs in response to growth factors and cytokines, and is essential for normal transcriptional activity of the ISGF3 complex. The 1/Stat1 monoclonal antibody recognizes the N-terminus of human Stat1 (both isoforms), regardless of phosphorylation status. |
Pathways | JAK-STAT Signaling, RTK Signaling, Interferon-gamma Pathway, Response to Growth Hormone Stimulus, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Endopeptidase Activity, Hepatitis C, CXCR4-mediated Signaling Events |
Application DetailsProduct Details anti-STAT1 Antibody Target Details STAT1 Handling References for anti-STAT1 antibody (ABIN1176937) Images back to top |
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Sample Volume | 20 μL |
Restrictions | For Research Use only |
HandlingProduct Details anti-STAT1 Antibody Target Details STAT1 Application Details References for anti-STAT1 antibody (ABIN1176937) Images back to top |
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Format | Liquid |
Buffer | Aqueous buffered solution containing BSA and ≤0.09 % sodium azide. |
Preservative | Sodium azide |
Precaution of Use | This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only. |
Storage | 4 °C |
Storage Comment | The antibody was conjugated with R-PE under optimum conditions, and unconjugated antibody and free PE were removed. Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze. |
References for anti-STAT1 antibody (ABIN1176937)Product Details anti-STAT1 Antibody Target Details STAT1 Application Details Handling Images back to top |
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Product cited in: |
Heim: "The Jak-STAT pathway: specific signal transduction from the cell membrane to the nucleus." in: European journal of clinical investigation, Vol. 26, Issue 1, pp. 1-12, 1996 |
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