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|Antigen||Glycogen Synthase Kinase 3 alpha (GSK3a) Antibodies|
|Reactivity||Human, Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This GSK3 alpha antibody is un-conjugated Alternatives|
Enzyme Immunoassay (EIA), Immunoprecipitation (IP), Western Blotting (WB)
|2 references available|
|Supplier||Log in to see|
Product Details anti-GSK3 alpha AntibodyTarget Details GSK3 alpha Application Details Handling References for anti-GSK3 alpha antibody (ABIN264482) Images
|Specificity||The antibody recognizes two isoforms of Glycogen Synthase kinase, GSK-3 alpha, a 51 kDa protein and GSK-3 beta, a 47 kDa protein.|
|Cross-Reactivity (Details)||Also reacts to: beta|
|Characteristics||Synonyms: Glycogen synthase kinase-3 alpha, GSK3A, GSK-3 alpha, Factor A|
|Purification||Protein A/G Chromatography|
|Immunogen||Hybridoma produced by the fusion of splenocytes from mice immunized with recombinantGSK-3alpha/beta from Xenopus laevis and mouse myeloma.|
Target Details GSK3 alphaProduct Details anti-GSK3 alpha Antibody Application Details Handling References for anti-GSK3 alpha antibody (ABIN264482) Images back to top
|Alternative Name||GSK3 alpha (GSK3a Antibody Abstract)|
|Background||Glycogen synthase kinase (GSK) is a protein serine kinase involved in the control of regulatory proteins such as glycogen synthase and the transcription factor, c-jun. In addition, it has been associated with the regulation of the microtubule-binding protein, Tau, thus indicating a potential role in the pathogenesis of Alzheimer's Disease.Synonyms: Factor A, GSK-3 alpha, GSK3A, Glycogen synthase kinase-3 alpha|
|Research Area||Cardiovascular, Hypertrophy, Atherosclerosis, Wnt, Kinases/Phosphatases, Wnt Signaling|
|Pathways||PI3K-Akt Signaling, WNT Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, cAMP Metabolic Process, Cellular Glucan Metabolic Process, Regulation of Muscle Cell Differentiation, Regulation of G-Protein Coupled Receptor Protein Signaling, ER-Nucleus Signaling, Regulation of Carbohydrate Metabolic Process|
Application DetailsProduct Details anti-GSK3 alpha Antibody Target Details GSK3 alpha Handling References for anti-GSK3 alpha antibody (ABIN264482) Images back to top
Western Blot: 0.5 - 1 μg/mL starting dilution. ELISA: 0.5 - 1 μg/mL starting dilution. Immunoprecipitation: 5 - 10 g per reaction. Enzyme Immunoassay. Positive Control: PC-12, A431 and 3T3-L1 cells.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-GSK3 alpha Antibody Target Details GSK3 alpha Application Details References for anti-GSK3 alpha antibody (ABIN264482) Images back to top
|Buffer||PBS, pH 7.4, 0.01 % Sodium Azide|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
The antibody can be shipped on dry ice. Store (in aliquots) at -20 °C to -70 °C. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
|Expiry Date||12 months|
References for anti-GSK3 alpha antibody (ABIN264482)Product Details anti-GSK3 alpha Antibody Target Details GSK3 alpha Application Details Handling Images back to top
Demarchi, Verardo, Varnum, Brancolini, Schneider: "Gas6 anti-apoptotic signaling requires NF-kappa B activation." in: The Journal of biological chemistry, Vol. 276, Issue 34, pp. 31738-44, 2001
Kitaura, Asai, Maeda-Yamamoto, Kawakami, Kikkawa, Kawakami: "Akt-dependent cytokine production in mast cells." in: The Journal of experimental medicine, Vol. 192, Issue 5, pp. 729-40, 2000
ImagesProduct Details anti-GSK3 alpha Antibody Target Details GSK3 alpha Application Details Handling References for anti-GSK3 alpha antibody (ABIN264482) back to top