Get this product for free
Submit your validation data for this product and get a full refund. I want to validate this productRelevance Score | ABIN | Application | Conjugate | Host | Isotype | Epitope | Supplier | Clonality | References | Details |
---|---|---|---|---|---|---|---|---|---|---|
14.762047 | ABIN2705254 | IC IF IP IHC WB | Rabbit | C-Term, pSer727 | Log in to see | Polyclonal | 0 | |||
14.762047 | ABIN1870637 | IF IHC WB | Rabbit | IgG | pSer727 | Log in to see | Polyclonal | 0 | ||
14.762047 | ABIN2957762 | IC IF IP IHC WB | Rabbit | C-Term, pTyr701 | Log in to see | Polyclonal | 0 | |||
14.5 | ABIN6255991 | ELISA ICC IF IHC IP WB | Rabbit | IgG | pTyr701 | Log in to see | Polyclonal | 2 | ||
14.5 | ABIN6265311 | ELISA ICC IF IHC IP WB | Rabbit | IgG | Log in to see | Polyclonal | 2 | |||
12.434076 | ABIN1842362 | IF IHC WB | Rabbit | IgG | pSer727 | Log in to see | Polyclonal | 0 | ||
10 | ABIN6652217 | IF IHC (p) WB | Rabbit | pSer727 | Log in to see | Polyclonal | 4 | |||
10 | ABIN6265313 | ELISA ICC IF IHC WB | Rabbit | IgG | Log in to see | Polyclonal | 0 | |||
8.762047 | ABIN6290945 | IF WB | Rabbit | IgG | Log in to see | Polyclonal | 0 | |||
7 | ABIN303289 | IF IHC (p) IP WB | Rabbit | C-Term | Log in to see | Polyclonal | 0 | |||
7 | ABIN6579986 | IF IHC WB | Rabbit | IgG | pSer727 | Log in to see | Polyclonal | 0 | ||
6.832951 | ABIN4356288 | ICC IF IHC IHC (p) WB | Rabbit | IgG | Log in to see | Polyclonal | 0 | |||
5.5 | ABIN362170 | IF IHC WB | Rabbit | IgG | pSer727 | Log in to see | Polyclonal | 5 | ||
5.0709047 | ABIN5947757 | FACS ICC IF IHC IHC (p) IP WB | Rabbit | IgG | C-Term | Log in to see | SD20-75 | 0 | ||
4 | ABIN5957642 | ELISA IF IHC (p) WB | Rabbit | IgG | pTyr701 | Log in to see | Polyclonal | 0 | ||
4 | ABIN5957648 | ELISA IF IHC (p) WB | Rabbit | IgG | Ser727 | Log in to see | Polyclonal | 0 | ||
1 | ABIN5555267 | EIA IF IP WB | Rabbit | IgG | C-Term | Log in to see | Polyclonal | 0 | ||
1 | ABIN2882786 | IF IHC WB | Rabbit | IgG | pSer727 | Log in to see | Polyclonal | 0 | ||
1 | ABIN2628793 | ICC IF IHC IHC (p) IP WB | Rabbit | pSer727 | Log in to see | Polyclonal | 0 | |||
1 | ABIN6714596 | IF IHC IP WB | Rabbit | Log in to see | Polyclonal | 0 |
General |
|
---|---|
Antigen | Signal Transducer and Activator of Transcription 1, 91kDa (STAT1) Antibodies |
Epitope | pSer727 Alternatives |
Reactivity | Human, Mouse (Murine), Rat (Rattus) Alternatives |
Host | Rabbit Alternatives |
Clonality | |
Conjugate | This STAT1 antibody is un-conjugated Alternatives |
Application |
ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blotting (WB)
Alternatives
|
![]() |
1 reference available |
Supplier | Log in to see |
Product Details anti-STAT1 AntibodyTarget Details STAT1 Application Details Handling References for anti-STAT1 antibody (ABIN6256410) Images |
|
Specificity | Phospho-STAT1 (Ser727) Antibody detects endogenous levels of STAT1 only when phosphorylated at Serine 727 |
Cross-Reactivity | Human, Mouse (Murine), Rat (Rattus) |
Purification | The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns. |
Immunogen | A synthesized peptide derived from human STAT1 around the phosphorylation site of Serine 727 |
Isotype | IgG |
Plasmids, Primers & others | |
Target Details STAT1Product Details anti-STAT1 Antibody Application Details Handling References for anti-STAT1 antibody (ABIN6256410) Images back to top |
|
Antigen | |
Alternative Name | STAT1 (STAT1 Antibody Abstract) |
Background |
Description: Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and other growth factors. Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus (PubMed:28753426). ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of IFN-stimulated genes (ISG), which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated (PubMed:26479788). It then forms a homodimer termed IFN-gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state. Becomes activated in response to KITLG/SCF and KIT signaling. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Gene: STAT1 |
Molecular Weight | 91kDa |
Gene ID | 6772 |
UniProt | P42224 |
Pathways | JAK-STAT Signaling, RTK Signaling, Interferon-gamma Pathway, Response to Growth Hormone Stimulus, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Endopeptidase Activity, Hepatitis C, CXCR4-mediated Signaling Events |
Application DetailsProduct Details anti-STAT1 Antibody Target Details STAT1 Handling References for anti-STAT1 antibody (ABIN6256410) Images back to top |
|
Application Notes | WB 1:500-1:2000 IHC 1:50-1:200, IF/ICC 1:100-1:500 |
Restrictions | For Research Use only |
HandlingProduct Details anti-STAT1 Antibody Target Details STAT1 Application Details References for anti-STAT1 antibody (ABIN6256410) Images back to top |
|
Format | Liquid |
Concentration | 1 mg/mL |
Buffer | Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol. |
Preservative | Sodium azide |
Precaution of Use | This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only. |
Storage | -20 °C |
Storage Comment | Store at -20 °C.Stable for 12 months from date of receipt |
Expiry Date | 12 months |
References for anti-STAT1 antibody (ABIN6256410)Product Details anti-STAT1 Antibody Target Details STAT1 Application Details Handling Images back to top |
|
Product cited in: |
Wu, Chen, Jing, Gu, Mei, Yao, Zhou, Yang, Sun, Wang, Hu, Wüthrich, Mei: "The C-terminal tail of polycystin-1 regulates complement factor B expression by signal transducer and activator of transcription 1." in: American journal of physiology. Renal physiology, Vol. 310, Issue 11, pp. F1284-94, 2017 |
ImagesProduct Details anti-STAT1 Antibody Target Details STAT1 Application Details Handling References for anti-STAT1 antibody (ABIN6256410) back to top |
|
Supplier Images |
|