PRKAA1/PRKAA2 Products
(AMPK1/AMPK2)
Categories
The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia. [provided by RefSeq, Jul 2008].
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Recommended PRKAA1/PRKAA2 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Monkey, Mouse, Rat
Application
WB, ELISA, IHC (p), IF
Validations
- (3)
Cat. No.
ABIN7250794
Quantity
200 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Pig, Rat, Sheep
Application
WB, ELISA, IF (cc), IHC (p), FACS, IF (p), IHC (fro)
Validations
- (4)
- (1)
Cat. No.
ABIN752368
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, IHC, IF
Validations
- (1)
Cat. No.
ABIN1842476
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our PRKAA1/PRKAA2 products
: "PDGFR Signaling Mediates Hyperproliferation and Fibrotic Responses of Subsynovial Connective Tissue Cells in Idiopathic Carpal Tunnel Syndrome." in: Scientific reports, Vol. 7, Issue 1, pp. 16192, (2019) (PubMed).: "Decrease in male mouse fertility by hydrogen sulfide and/or ammonia can Be inheritable." in: Chemosphere, Vol. 194, pp. 147-157, (2018) (PubMed).
: "Regulation of steroid hormones and energy status with cysteamine and its effect on spermatogenesis." in: Toxicology and applied pharmacology, Vol. 313, pp. 149-158, (2016) (PubMed).
: "Hydrogen Sulfide and/or Ammonia Reduces Spermatozoa Motility through AMPK/AKT Related Pathways." in: Scientific reports, Vol. 6, pp. 37884, (2016) (PubMed).
: "Mitochondrial biogenesis fails in secondary biliary cirrhosis in rats leading to mitochondrial DNA depletion and deletions." in: American journal of physiology. Gastrointestinal and liver physiology, Vol. 301, Issue 1, pp. G119-27, (2011) (PubMed).
: "Global phosphoproteome of HT-29 human colon adenocarcinoma cells." in: Journal of proteome research, Vol. 4, Issue 4, pp. 1339-46, (2005) (PubMed).
: "Identification of phosphorylation sites in AMP-activated protein kinase (AMPK) for upstream AMPK kinases and study of their roles by site-directed mutagenesis." in: The Journal of biological chemistry, Vol. 278, Issue 31, pp. 28434-42, (2003) (PubMed).
Synonyms and alternative names related to PRKAA1/PRKAA2
protein kinase AMP-activated catalytic subunit alpha 2 (PRKAA2), protein kinase AMP-activated catalytic subunit alpha 2 (Prkaa2), protein kinase, AMP-activated, alpha 2 catalytic subunit (Prkaa2), 2310008I11Rik, A830082D05, AMPK, Ampk, AMPK2, AMPKa2, Ampka2, AMPKalpha2, PRKAAProtein level used designations for PRKAA1/PRKAA2
- 5'-AMP-activated protein kinase catalytic subunit alpha-2
- 5'-AMP-activated protein kinase, catalytic alpha-2 chain
- ACACA kinase
- AMPK subunit alpha-2
- AMPK-alpha-2 chain
- HMGCR kinase
- acetyl-CoA carboxylase kinase
- hydroxymethylglutaryl-CoA reductase kinase
- AMP-activated protein kinase
- AMPK alpha-2 chain
- AMP-activated protein kinase alpha-2 variant B
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