Tumor Necrosis Factor Receptor Superfamily, Member 17 (TNFRSF17) (AA 2-54), (Extracellular Domain) (Active) protein (Fc Tag)

Details for Product No. ABIN1344234, Supplier: Log in to see
Protein Name
  • TNFRSF17
  • BCM
  • BCMA
  • CD269
  • TNFRSF13A
  • Tnfrsf13
  • Tnfrsf13a
  • TNF receptor superfamily member 17
  • tumor necrosis factor receptor superfamily, member 17
  • Tnfrsf17
  • TNFRSF17
Protein Characteristics
Extracellular Domain, AA 2-54
12
8
6
4
4
2
2
2
1
1
1
1
1
Origin
Human, Mouse (Murine)
43
17
7
6
1
Source
HEK-293 Cells
23
20
6
6
3
2
2
1
Protein Type
Recombinant
Biological Activity
Active
Purification tag / Conjugate
This TNFRSF17 protein is labelled with Fc Tag.
Application
SDS-PAGE (SDS)
Options
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Specificity Binds human and mouse BAFF and APRIL.
Cross-Reactivity Human, Mouse (Murine)
Characteristics The extracellular domain of human BCMA (aa 2-54) is fused at the C-terminus to the Fc portion of human IgG1.
Purity >95 % (SDS-PAGE)
Endotoxin Level <0.01EU/μg purified protein (LAL test, Lonza).
Background BCMA is a receptor for BAFF and APRIL. It promotes B cell survival and plays a role in the regulation of humoral immunity. Its downstream signaling is dependent on NF-kappaB and JNK.
Molecular Weight ~40kDa (SDS-PAGE)
UniProt Q02223
Application Notes Optimal working dilution should be determined by the investigator.
Comment

Blocks the binding of BAFF and APRIL to their receptors BCMA and TACI, inhibiting BAFF- and APRIL-mediated B cell activation.

Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute with 50 μL sterile water.
Concentration 1 mg/mL
Buffer Lyophilized. Contains PBS.
Storage 4 °C,-20 °C
Storage Comment Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 6 months after receipt when stored at -20°C.
Expiry Date 6 months
Product cited in: Huard, Tran, Benkhoucha, Manzin-Lorenzi, Santiago-Raber: "Selective APRIL blockade delays systemic lupus erythematosus in mouse." in: PLoS ONE, Vol. 7, Issue 2, pp. e31837, 2012 (PubMed).

Huard, Arlettaz, Ambrose, Kindler, Mauri, Roosnek, Tschopp, Schneider, French: "BAFF production by antigen-presenting cells provides T cell co-stimulation." in: International immunology, Vol. 16, Issue 3, pp. 467-75, 2004 (PubMed).

Huard, Schneider, Mauri, Tschopp, French: "T cell costimulation by the TNF ligand BAFF." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 167, Issue 11, pp. 6225-31, 2001 (PubMed).

Rennert, Schneider, Cachero, Thompson, Trabach, Hertig, Holler, Qian, Mullen, Strauch, Browning, Ambrose, Tschopp: "A soluble form of B cell maturation antigen, a receptor for the tumor necrosis factor family member APRIL, inhibits tumor cell growth." in: The Journal of experimental medicine, Vol. 192, Issue 11, pp. 1677-84, 2000 (PubMed).

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