GTPase NRas Protein (NRAS) (AA 1-186)

Catalog No. ABIN935092

Product Details

Target: GTPase NRas (NRAS)

Protein Type: Recombinant

Protein Characteristics: AA 1-186

Origin: Human

Source: Escherichia coli (E. coli)

Application: SDS-PAGE (SDS)

Sequence: MTEYKLVVVG AGGVGKSALT IQLIQNHFVD EYDPTIEDSY RKQVVIDGET CLLDILDTAG QEEYSAMRDQ YMRTGEGFLC VFAINNSKSF ADINLYREQI KRVKDSDDVP MVLVGNKCDL PTRTVDTKQA HELAKSYGIP FIETSAKTRQ GVEDAFYTLV REIRQYRMKK LNSSDDGTQG CMGLPC

Characteristics: Purified recombinant Human NRAS protein
Expression System: E.coli

Purity: > 95 % pure

Application Details

Application Notes: NRAS protein has been used in SDS PAGE and may be suitable for use in other assays to be determined by the end user.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Supplied as a liquid in 20 mM Tris-HCl buffer, pH 7.5, containing 100 mM NaCl, 10 % glycerol.

Handling Advice: Avoid repeated freeze/thaw cycles.

Storage: RT/-20 °C

Storage Comment: Store at 4 °C for short term storage (1/2 weeks). Aliquot and store at -20 °C or - 70 °C for long term storage.

Target Details

Target: GTPase NRas (NRAS)

Alternative Name: NRAS (NRAS Products)

Synonyms: NRAS Protein, AV095280 Protein, N-ras Protein, ALPS4 Protein, NRAS1 Protein, NS6 Protein, N-RAS Protein, fj99a10 Protein, wu:fj99a10 Protein, zgc:100761 Protein, zras-b1 Protein, H-RAS Protein, HRAS Protein, GTPase NRas Protein, neuroblastoma RAS viral (v-ras) oncogene homolog L homeolog Protein, NRAS proto-oncogene, GTPase Protein, neuroblastoma ras oncogene Protein, neuroblastoma RAS viral oncogene homolog Protein, Tsp_01117 Protein, nras.L Protein, Nras Protein, NRAS Protein, nras Protein

Background: Neuroblastoma RAS viral (v-ras) oncogene homolog, also known as NRAS, is a member of the RAS gene family. NRAS is an oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. The encoded protein, which has intrinsic GTPase activity, is activated to a GTP-bound form by a GTPase activating protein and inactivated to a GDP-bound form by a guanine nucleotide-exchange factor. Recombinant human NRAS was expressed in E. coli and purified by using conventional chromatography techniques.
Alternative Names: N ras protein part 4 protein, HRAS1 protein, v ras neuroblastoma RAS viral oncogene homolog, NS6 protein, OTTHUMP00000013879 protein, Neuroblastoma RAS viral (v ras) oncogene homolog protein, ALPS4 protein, GTPase NRas protein, AV095280 protein, N ras protein, Transforming protein N Ras protein, N-ras protein, NRAS1 protein, Neuroblastoma RAS viral (v-ras) oncogene homolog OTTMUSP00000023521 protein

Molecular Weight: 20.8 kDa (186 AA)

Pathways: p53 Signaling, MAPK Signaling, RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Hepatitis C, Regulation of long-term Neuronal Synaptic Plasticity, VEGF Signaling