anti-Pig (Porcine) SIGIRR antibody for Immunohistochemistry

Recommended SIGIRR Antibody (supplied by: Log in to see )

Antigen
Single Immunoglobulin and Toll-Interleukin 1 Receptor (TIR) Domain (SIGIRR) Antibodies
  • TIR8
  • AI256711
  • sc:d148
  • RGD1306732
  • single Ig and TIR domain containing
  • single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
  • SIGIRR
  • Sigirr
  • sigirr
Epitope
C-Term
20
15
12
6
6
3
3
2
2
2
1
Reactivity
Cow (Bovine), Dog (Canine), Guinea Pig, Horse (Equine), Human, Mouse (Murine), Pig (Porcine), Rat (Rattus), Zebrafish (Danio rerio)
66
36
11
1
1
1
1
1
1
Host
Rabbit
74
8
1
Clonality
Polyclonal
Conjugate
This SIGIRR antibody is un-conjugated
8
3
3
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (IHC), Western Blotting (WB)
74
19
16
6
6
6
5
5
5
3
3
1
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Available images

Catalog No. ABIN2783841
$ 289.00
Plus shipping costs $45.00

General

Antigen Single Immunoglobulin and Toll-Interleukin 1 Receptor (TIR) Domain (SIGIRR) Antibodies
Epitope C-Term
(20), (15), (12), (6), (6), (3), (3), (2), (2), (2), (1)
Reactivity Cow (Bovine), Dog (Canine), Guinea Pig, Horse (Equine), Human, Mouse (Murine), Pig (Porcine), Rat (Rattus), Zebrafish (Danio rerio)
(66), (36), (11), (1), (1), (1), (1), (1), (1)
Host Rabbit
(74), (8), (1)
Clonality
Polyclonal
Conjugate This SIGIRR antibody is un-conjugated
(8), (3), (3), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Immunohistochemistry (IHC), Western Blotting (WB)
(74), (19), (16), (6), (6), (6), (5), (5), (5), (3), (3), (1)
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Product Details anti-SIGIRR Antibody

Target Details SIGIRR Application Details Handling Images
Blocking Peptide Blocking peptide for this product available: ABIN983733
Sequence PVFGEPSAPP HTSGVSLGES RSSEVDVSDL GSRNYSARTD FYCLVSKDDM
Predicted Reactivity Cow: 100%, Dog: 100%, Guinea Pig: 86%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rat: 100%, Zebrafish: 86%
Characteristics This is a rabbit polyclonal antibody against SIGIRR. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Immunogen The immunogen is a synthetic peptide directed towards the C terminal region of human SIGIRR
Plasmids, Primers & others

Target Details SIGIRR

Product Details anti-SIGIRR Antibody Application Details Handling Images back to top
Antigen
Alternative Name SIGIRR (SIGIRR Antibody Abstract)
Background SIGIRR acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. It attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through a TIR-TIR domain interaction with TLR4. Through its extracellular domain it interferes with the heterodimerization of Il1R1 and IL1RAP.
Alias Symbols: MGC110992, TIR8
Protein Interaction Partner: APP, UBC, SIGIRR, TLR9, TLR5, TLR4, TRAF6, IRAK1, RPN1, IL1R1, ENO2,
Protein Size: 224
Molecular Weight 25 kDa
Gene ID 59307
UniProt Q6IA17
Pathways Toll-Like Receptors Cascades

Application Details

Product Details anti-SIGIRR Antibody Target Details SIGIRR Handling Images back to top
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 224 AA

Restrictions For Research Use only

Handling

Product Details anti-SIGIRR Antibody Target Details SIGIRR Application Details Images back to top
Format Liquid
Concentration Lot specific
Buffer Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Images

Product Details anti-SIGIRR Antibody Target Details SIGIRR Application Details Handling back to top
Supplier Images
Immunohistochemistry (IHC) image for anti-Single Immunoglobulin and Toll-Interleukin 1 Receptor (TIR) Domain (SIGIRR) (C-Term) antibody (ABIN2783841) anti-Single Immunoglobulin and Toll-Interleukin 1 Receptor (TIR) Domain (SIGIRR) (C-Term) antibody
Western Blotting (WB) image for anti-Single Immunoglobulin and Toll-Interleukin 1 Receptor (TIR) Domain (SIGIRR) (C-Term) antibody (ABIN2783841) WB Suggested Anti-SIGIRR Antibody Titration: 0.2-1 ug/ml Positive Control: Jurkat ...
Western Blotting (WB) image for anti-Single Immunoglobulin and Toll-Interleukin 1 Receptor (TIR) Domain (SIGIRR) (C-Term) antibody (ABIN2783841) Host: Rabbit Target Name: SIGIRR Sample Type: Human Adult Placenta Antibody Di...